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Gene: GBAS |
Gene summary for GBAS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GBAS | Gene ID | 2631 |
| Gene name | nipsnap homolog 2 | |
| Gene Alias | GBAS | |
| Cytomap | 7p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | O75323 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2631 | GBAS | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.49e-43 | 7.42e-01 | 0.294 |
| 2631 | GBAS | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.40e-05 | 8.07e-01 | 0.3487 |
| 2631 | GBAS | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.99e-33 | 9.41e-01 | 0.281 |
| 2631 | GBAS | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.80e-25 | 5.34e-01 | 0.3859 |
| 2631 | GBAS | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.03e-16 | 5.63e-01 | 0.2585 |
| 2631 | GBAS | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.17e-24 | 4.95e-01 | 0.3005 |
| 2631 | GBAS | P1T-E | Human | Esophagus | ESCC | 4.82e-05 | 7.08e-01 | 0.0875 |
| 2631 | GBAS | P2T-E | Human | Esophagus | ESCC | 1.91e-62 | 1.36e+00 | 0.1177 |
| 2631 | GBAS | P4T-E | Human | Esophagus | ESCC | 4.22e-43 | 1.27e+00 | 0.1323 |
| 2631 | GBAS | P5T-E | Human | Esophagus | ESCC | 5.46e-18 | 4.17e-01 | 0.1327 |
| 2631 | GBAS | P8T-E | Human | Esophagus | ESCC | 4.52e-46 | 7.85e-01 | 0.0889 |
| 2631 | GBAS | P9T-E | Human | Esophagus | ESCC | 3.94e-13 | 3.62e-01 | 0.1131 |
| 2631 | GBAS | P10T-E | Human | Esophagus | ESCC | 2.65e-48 | 1.05e+00 | 0.116 |
| 2631 | GBAS | P11T-E | Human | Esophagus | ESCC | 1.67e-11 | 4.16e-01 | 0.1426 |
| 2631 | GBAS | P12T-E | Human | Esophagus | ESCC | 4.18e-57 | 1.34e+00 | 0.1122 |
| 2631 | GBAS | P15T-E | Human | Esophagus | ESCC | 1.23e-47 | 1.30e+00 | 0.1149 |
| 2631 | GBAS | P16T-E | Human | Esophagus | ESCC | 2.23e-61 | 1.51e+00 | 0.1153 |
| 2631 | GBAS | P17T-E | Human | Esophagus | ESCC | 1.74e-10 | 7.37e-01 | 0.1278 |
| 2631 | GBAS | P19T-E | Human | Esophagus | ESCC | 4.49e-06 | 9.05e-01 | 0.1662 |
| 2631 | GBAS | P20T-E | Human | Esophagus | ESCC | 3.92e-29 | 6.92e-01 | 0.1124 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GBAS | SNV | Missense_Mutation | novel | c.828N>G | p.Ile276Met | p.I276M | O75323 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| GBAS | SNV | Missense_Mutation | c.254N>A | p.Cys85Tyr | p.C85Y | O75323 | protein_coding | tolerated(0.18) | probably_damaging(0.998) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| GBAS | SNV | Missense_Mutation | c.224A>C | p.Lys75Thr | p.K75T | O75323 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-3732-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | capecitabine | SD | |
| GBAS | SNV | Missense_Mutation | novel | c.116G>T | p.Arg39Ile | p.R39I | O75323 | protein_coding | deleterious(0.03) | benign(0.369) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GBAS | SNV | Missense_Mutation | novel | c.626C>T | p.Ala209Val | p.A209V | O75323 | protein_coding | deleterious(0) | possibly_damaging(0.89) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| GBAS | SNV | Missense_Mutation | rs770231289 | c.460N>T | p.Arg154Cys | p.R154C | O75323 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GBAS | SNV | Missense_Mutation | rs775475871 | c.745N>T | p.Arg249Trp | p.R249W | O75323 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GBAS | SNV | Missense_Mutation | novel | c.428N>C | p.Lys143Thr | p.K143T | O75323 | protein_coding | tolerated(0.16) | possibly_damaging(0.621) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| GBAS | SNV | Missense_Mutation | novel | c.764N>G | p.Lys255Arg | p.K255R | O75323 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GBAS | SNV | Missense_Mutation | novel | c.287T>C | p.Val96Ala | p.V96A | O75323 | protein_coding | tolerated(0.1) | benign(0.106) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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