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Gene: GATAD1 |
Gene summary for GATAD1 |
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Gene information | Species | Human | Gene symbol | GATAD1 | Gene ID | 57798 |
Gene name | GATA zinc finger domain containing 1 | |
Gene Alias | CMD2B | |
Cytomap | 7q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8WUU5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57798 | GATAD1 | LZE4T | Human | Esophagus | ESCC | 1.81e-08 | 1.07e-01 | 0.0811 |
57798 | GATAD1 | LZE7T | Human | Esophagus | ESCC | 4.31e-04 | 1.59e-01 | 0.0667 |
57798 | GATAD1 | LZE8T | Human | Esophagus | ESCC | 8.50e-04 | 7.54e-02 | 0.067 |
57798 | GATAD1 | LZE20T | Human | Esophagus | ESCC | 1.84e-04 | 8.29e-02 | 0.0662 |
57798 | GATAD1 | LZE24T | Human | Esophagus | ESCC | 1.34e-09 | 3.48e-01 | 0.0596 |
57798 | GATAD1 | P1T-E | Human | Esophagus | ESCC | 8.32e-04 | 4.00e-01 | 0.0875 |
57798 | GATAD1 | P2T-E | Human | Esophagus | ESCC | 1.74e-26 | 3.91e-01 | 0.1177 |
57798 | GATAD1 | P4T-E | Human | Esophagus | ESCC | 1.50e-09 | 3.34e-01 | 0.1323 |
57798 | GATAD1 | P5T-E | Human | Esophagus | ESCC | 1.18e-12 | 8.75e-02 | 0.1327 |
57798 | GATAD1 | P8T-E | Human | Esophagus | ESCC | 9.47e-23 | 3.20e-01 | 0.0889 |
57798 | GATAD1 | P9T-E | Human | Esophagus | ESCC | 4.73e-10 | 2.37e-01 | 0.1131 |
57798 | GATAD1 | P10T-E | Human | Esophagus | ESCC | 1.47e-22 | 4.84e-01 | 0.116 |
57798 | GATAD1 | P11T-E | Human | Esophagus | ESCC | 1.50e-07 | 2.10e-01 | 0.1426 |
57798 | GATAD1 | P12T-E | Human | Esophagus | ESCC | 3.94e-29 | 5.66e-01 | 0.1122 |
57798 | GATAD1 | P15T-E | Human | Esophagus | ESCC | 1.08e-20 | 4.49e-01 | 0.1149 |
57798 | GATAD1 | P16T-E | Human | Esophagus | ESCC | 1.78e-36 | 8.49e-01 | 0.1153 |
57798 | GATAD1 | P20T-E | Human | Esophagus | ESCC | 4.74e-19 | 5.01e-01 | 0.1124 |
57798 | GATAD1 | P21T-E | Human | Esophagus | ESCC | 2.96e-13 | 1.08e-01 | 0.1617 |
57798 | GATAD1 | P22T-E | Human | Esophagus | ESCC | 3.09e-14 | 1.55e-01 | 0.1236 |
57798 | GATAD1 | P23T-E | Human | Esophagus | ESCC | 3.14e-28 | 7.41e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GATAD1 | SNV | Missense_Mutation | c.505C>G | p.Gln169Glu | p.Q169E | Q8WUU5 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GATAD1 | deletion | Frame_Shift_Del | novel | c.665_671delNNNNNNN | p.Cys223HisfsTer35 | p.C223Hfs*35 | Q8WUU5 | protein_coding | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | ||
GATAD1 | SNV | Missense_Mutation | c.305C>T | p.Ser102Phe | p.S102F | Q8WUU5 | protein_coding | deleterious(0.05) | probably_damaging(0.979) | TCGA-DM-A285-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GATAD1 | insertion | Frame_Shift_Ins | novel | c.598_599insGTAATAT | p.Asp200GlyfsTer31 | p.D200Gfs*31 | Q8WUU5 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GATAD1 | SNV | Missense_Mutation | novel | c.467C>A | p.Ser156Tyr | p.S156Y | Q8WUU5 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GATAD1 | SNV | Missense_Mutation | novel | c.688T>G | p.Phe230Val | p.F230V | Q8WUU5 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GATAD1 | SNV | Missense_Mutation | rs780188711 | c.578N>G | p.Ser193Cys | p.S193C | Q8WUU5 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GATAD1 | SNV | Missense_Mutation | c.381N>G | p.Ile127Met | p.I127M | Q8WUU5 | protein_coding | tolerated(0.09) | possibly_damaging(0.809) | TCGA-05-4430-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GATAD1 | SNV | Missense_Mutation | novel | c.604N>T | p.Ala202Ser | p.A202S | Q8WUU5 | protein_coding | tolerated(0.36) | benign(0.015) | TCGA-69-8255-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GATAD1 | SNV | Missense_Mutation | novel | c.690C>G | p.Phe230Leu | p.F230L | Q8WUU5 | protein_coding | deleterious(0.01) | benign(0.056) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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