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Gene: GARS1 |
Gene summary for GARS1 |
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Gene information | Species | Human | Gene symbol | GARS1 | Gene ID | 2617 |
Gene name | glycyl-tRNA synthetase 1 | |
Gene Alias | CMT2D | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | A0A090N8G0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2617 | GARS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.84e-04 | 1.23e-01 | 0.0155 |
2617 | GARS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.68e-08 | 2.50e-01 | -0.1808 |
2617 | GARS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.58e-13 | 3.82e-01 | -0.0811 |
2617 | GARS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.82e-22 | 5.03e-01 | -0.1088 |
2617 | GARS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-17 | 3.36e-01 | -0.1954 |
2617 | GARS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.86e-06 | 4.38e-01 | -0.2602 |
2617 | GARS1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.76e-08 | 5.07e-01 | -0.2196 |
2617 | GARS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.91e-05 | 2.13e-01 | -0.1207 |
2617 | GARS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.13e-10 | 3.34e-01 | -0.1526 |
2617 | GARS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.82e-01 | -0.1464 |
2617 | GARS1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.52e-13 | 2.71e-01 | -0.1001 |
2617 | GARS1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.25e-23 | 5.78e-01 | -0.059 |
2617 | GARS1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.41e-01 | -0.1462 |
2617 | GARS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.65e-04 | 1.99e-01 | -0.0842 |
2617 | GARS1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.60e-01 | -0.0179 |
2617 | GARS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-08 | 2.17e-01 | 0.096 |
2617 | GARS1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.79e-07 | 3.89e-01 | 0.0446 |
2617 | GARS1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 2.31e-01 | 0.0131 |
2617 | GARS1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.36e-03 | 1.87e-01 | -0.0177 |
2617 | GARS1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.07e-13 | 6.21e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:1901293 | Colorectum | AD | nucleoside phosphate biosynthetic process | 80/3918 | 256/18723 | 6.31e-05 | 1.05e-03 | 80 |
GO:0009165 | Colorectum | AD | nucleotide biosynthetic process | 79/3918 | 254/18723 | 8.33e-05 | 1.30e-03 | 79 |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00064181 | Colorectum | SER | tRNA aminoacylation for protein translation | 17/2897 | 41/18723 | 5.75e-05 | 1.35e-03 | 17 |
GO:00430391 | Colorectum | SER | tRNA aminoacylation | 17/2897 | 44/18723 | 1.64e-04 | 3.12e-03 | 17 |
GO:00430381 | Colorectum | SER | amino acid activation | 17/2897 | 45/18723 | 2.25e-04 | 3.91e-03 | 17 |
GO:00091651 | Colorectum | SER | nucleotide biosynthetic process | 58/2897 | 254/18723 | 1.21e-03 | 1.38e-02 | 58 |
GO:19012931 | Colorectum | SER | nucleoside phosphate biosynthetic process | 58/2897 | 256/18723 | 1.47e-03 | 1.59e-02 | 58 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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