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Gene: GARS-DT |
Gene summary for GARS-DT |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GARS-DT | Gene ID | 401320 |
| Gene name | GARS1 divergent transcript | |
| Gene Alias | GARS-DT | |
| Cytomap | 7p14.3 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 401320 | GARS-DT | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.12e-03 | 3.79e-01 | 0.3329 |
| 401320 | GARS-DT | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.98e-05 | 3.39e-01 | -0.2119 |
| 401320 | GARS-DT | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.17e-04 | 4.59e-01 | 0.1829 |
| 401320 | GARS-DT | RNA-P3T-P3T-2 | Human | Lung | IAC | 1.31e-02 | 3.76e-01 | 0.1835 |
| 401320 | GARS-DT | RNA-P3T-P3T-4 | Human | Lung | IAC | 8.54e-11 | 6.87e-01 | 0.1859 |
| 401320 | GARS-DT | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 6.71e-01 | -0.0238 |
| 401320 | GARS-DT | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 9.90e-04 | 8.13e-01 | -0.0296 |
| 401320 | GARS-DT | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 3.32e-17 | 5.20e-01 | -0.0166 |
| 401320 | GARS-DT | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.34e-16 | 4.99e-01 | -0.0132 |
| 401320 | GARS-DT | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.84e-18 | 5.22e-01 | -0.013 |
| 401320 | GARS-DT | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.60e-14 | 4.80e-01 | -0.0121 |
| 401320 | GARS-DT | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.94e-06 | 5.34e-01 | -0.0961 |
| 401320 | GARS-DT | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 1.46e-05 | 4.38e-01 | -0.0876 |
| 401320 | GARS-DT | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.74e-03 | 4.13e-01 | -0.0822 |
| 401320 | GARS-DT | HTA12-26-1 | Human | Pancreas | PDAC | 1.71e-17 | 8.28e-01 | 0.3728 |
| 401320 | GARS-DT | HTA12-29-1 | Human | Pancreas | PDAC | 5.44e-24 | 6.67e-01 | 0.3722 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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