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Gene: GALNT5 |
Gene summary for GALNT5 |
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Gene information | Species | Human | Gene symbol | GALNT5 | Gene ID | 11227 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 5 | |
Gene Alias | GALNAC-T5 | |
Cytomap | 2q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006022 | UniProtAcc | Q7Z7M9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11227 | GALNT5 | HCC2_Meng | Human | Liver | HCC | 1.02e-51 | 4.87e-01 | 0.0107 |
11227 | GALNT5 | HCC1 | Human | Liver | HCC | 7.77e-09 | 1.07e+00 | 0.5336 |
11227 | GALNT5 | HCC2 | Human | Liver | HCC | 5.95e-21 | 1.35e+00 | 0.5341 |
11227 | GALNT5 | HCC5 | Human | Liver | HCC | 5.72e-12 | 1.25e+00 | 0.4932 |
11227 | GALNT5 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.69e-11 | 5.91e-01 | -0.2116 |
11227 | GALNT5 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.18e-04 | 5.94e-01 | -0.1941 |
11227 | GALNT5 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 6.25e-07 | 7.44e-01 | -0.2107 |
11227 | GALNT5 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.72e-07 | 5.99e-01 | -0.2119 |
11227 | GALNT5 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 8.42e-04 | 8.69e-01 | -0.2027 |
11227 | GALNT5 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 3.66e-10 | 6.78e-01 | -0.1833 |
11227 | GALNT5 | 052097_1595-all-cells | Human | Prostate | BPH | 1.82e-07 | 3.64e-01 | 0.0972 |
11227 | GALNT5 | ATC11 | Human | Thyroid | ATC | 5.35e-04 | 5.38e-01 | 0.3386 |
11227 | GALNT5 | ATC12 | Human | Thyroid | ATC | 5.43e-04 | 1.17e-01 | 0.34 |
11227 | GALNT5 | ATC2 | Human | Thyroid | ATC | 2.02e-16 | 2.16e+00 | 0.34 |
11227 | GALNT5 | ATC3 | Human | Thyroid | ATC | 4.97e-10 | 6.07e-01 | 0.338 |
11227 | GALNT5 | ATC4 | Human | Thyroid | ATC | 1.63e-06 | 1.69e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:0006493 | Lung | AIS | protein O-linked glycosylation | 17/1849 | 86/18723 | 4.04e-03 | 3.65e-02 | 17 |
GO:00064863 | Lung | AIS | protein glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
GO:00434133 | Lung | AIS | macromolecule glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
GO:000648612 | Thyroid | ATC | protein glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:004341312 | Thyroid | ATC | macromolecule glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT5 | SNV | Missense_Mutation | novel | c.304N>A | p.Glu102Lys | p.E102K | Q7Z7M9 | protein_coding | tolerated(0.38) | benign(0) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
GALNT5 | SNV | Missense_Mutation | c.181N>T | p.Pro61Ser | p.P61S | Q7Z7M9 | protein_coding | tolerated(0.22) | benign(0.011) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
GALNT5 | SNV | Missense_Mutation | c.52N>C | p.Ile18Leu | p.I18L | Q7Z7M9 | protein_coding | deleterious(0.01) | possibly_damaging(0.556) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GALNT5 | SNV | Missense_Mutation | c.1987N>C | p.Asp663His | p.D663H | Q7Z7M9 | protein_coding | deleterious(0) | benign(0.335) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
GALNT5 | SNV | Missense_Mutation | c.2518N>C | p.Glu840Gln | p.E840Q | Q7Z7M9 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
GALNT5 | insertion | Nonsense_Mutation | novel | c.1797_1798insAAAATTGATAAGCCATTTAGAATGGGCAAAAGAATCTGAAAAGAATACTTGGTATTGAATGTAACGTTGGTTGGTTGGAA | p.Pro600LysfsTer13 | p.P600Kfs*13 | Q7Z7M9 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GALNT5 | SNV | Missense_Mutation | c.1678C>A | p.Leu560Ile | p.L560I | Q7Z7M9 | protein_coding | tolerated(0.17) | benign(0.291) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GALNT5 | SNV | Missense_Mutation | c.1692G>C | p.Glu564Asp | p.E564D | Q7Z7M9 | protein_coding | deleterious(0.04) | possibly_damaging(0.55) | TCGA-C5-A1MI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
GALNT5 | insertion | Frame_Shift_Ins | novel | c.1241dupT | p.Leu414PhefsTer3 | p.L414Ffs*3 | Q7Z7M9 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
GALNT5 | SNV | Missense_Mutation | novel | c.2345N>G | p.Glu782Gly | p.E782G | Q7Z7M9 | protein_coding | deleterious(0.01) | possibly_damaging(0.631) | TCGA-A6-2675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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