![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GALNT4 |
Gene summary for GALNT4 |
![]() |
Gene information | Species | Human | Gene symbol | GALNT4 | Gene ID | 8693 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 4 | |
Gene Alias | GALNAC-T4 | |
Cytomap | 12q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N4A0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8693 | GALNT4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.55e-09 | 2.37e-01 | 0.0155 |
8693 | GALNT4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.26e-23 | 5.75e-01 | -0.1808 |
8693 | GALNT4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.16e-29 | 6.75e-01 | -0.0811 |
8693 | GALNT4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.84e-40 | 8.81e-01 | -0.1088 |
8693 | GALNT4 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.33e-36 | 6.42e-01 | -0.1954 |
8693 | GALNT4 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-10 | 8.01e-01 | -0.2602 |
8693 | GALNT4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.23e-14 | 6.83e-01 | -0.2196 |
8693 | GALNT4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.67e-12 | 3.79e-01 | -0.1207 |
8693 | GALNT4 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.16e-09 | 3.09e-01 | -0.1526 |
8693 | GALNT4 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.56e-30 | 5.23e-01 | -0.1464 |
8693 | GALNT4 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.91e-23 | 4.36e-01 | -0.1001 |
8693 | GALNT4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.20e-22 | 4.42e-01 | -0.059 |
8693 | GALNT4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.40e-13 | 5.46e-01 | -0.1706 |
8693 | GALNT4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.21e-08 | 3.63e-01 | -0.2061 |
8693 | GALNT4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.52e-01 | -0.1462 |
8693 | GALNT4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.01e-16 | 5.31e-01 | -0.0842 |
8693 | GALNT4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.15e-10 | 3.88e-01 | -0.0179 |
8693 | GALNT4 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.28e-08 | 2.39e-01 | 0.096 |
8693 | GALNT4 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.52e-01 | 0.0446 |
8693 | GALNT4 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.03e-05 | 3.39e-01 | 0.0451 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0018210 | Colorectum | AD | peptidyl-threonine modification | 40/3918 | 125/18723 | 2.44e-03 | 1.88e-02 | 40 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00182091 | Colorectum | MSS | peptidyl-serine modification | 84/3467 | 338/18723 | 2.12e-03 | 1.79e-02 | 84 |
GO:00182101 | Colorectum | MSS | peptidyl-threonine modification | 36/3467 | 125/18723 | 3.28e-03 | 2.49e-02 | 36 |
GO:00182107 | Endometrium | AEH | peptidyl-threonine modification | 25/2100 | 125/18723 | 2.84e-03 | 2.04e-02 | 25 |
GO:001821013 | Endometrium | EEC | peptidyl-threonine modification | 28/2168 | 125/18723 | 4.23e-04 | 4.42e-03 | 28 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT4 | insertion | Nonsense_Mutation | novel | c.1356_1357insTGAATGAATGACTGAATGAATGA | p.Ile453Ter | p.I453* | Q8N4A0 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GALNT4 | insertion | Frame_Shift_Ins | novel | c.1354_1355insCTTTCAGTAAGTG | p.Gly452AlafsTer9 | p.G452Afs*9 | Q8N4A0 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GALNT4 | insertion | In_Frame_Ins | novel | c.855_856insCACATTAAA | p.Gln285_Trp286insHisIleLys | p.Q285_W286insHIK | Q8N4A0 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GALNT4 | SNV | Missense_Mutation | rs201726968 | c.5N>T | p.Ala2Val | p.A2V | Q8N4A0 | protein_coding | tolerated_low_confidence(0.18) | benign(0.011) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GALNT4 | SNV | Missense_Mutation | c.935N>A | p.Gly312Glu | p.G312E | Q8N4A0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GALNT4 | SNV | Missense_Mutation | c.912N>G | p.Ile304Met | p.I304M | Q8N4A0 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GALNT4 | SNV | Missense_Mutation | c.211N>G | p.Ser71Ala | p.S71A | Q8N4A0 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
GALNT4 | SNV | Missense_Mutation | novel | c.798N>A | p.Phe266Leu | p.F266L | Q8N4A0 | protein_coding | deleterious(0) | benign(0.411) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GALNT4 | SNV | Missense_Mutation | c.409N>G | p.Thr137Ala | p.T137A | Q8N4A0 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
GALNT4 | SNV | Missense_Mutation | c.361A>C | p.Met121Leu | p.M121L | Q8N4A0 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |