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Gene: GALNT18 |
Gene summary for GALNT18 |
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Gene information | Species | Human | Gene symbol | GALNT18 | Gene ID | 374378 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 18 | |
Gene Alias | GALNACT18 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q58A54 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374378 | GALNT18 | LZE4T | Human | Esophagus | ESCC | 1.20e-04 | 1.40e-01 | 0.0811 |
374378 | GALNT18 | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 2.10e-01 | 0.0514 |
374378 | GALNT18 | LZE8T | Human | Esophagus | ESCC | 1.10e-02 | 1.44e-01 | 0.067 |
374378 | GALNT18 | LZE20T | Human | Esophagus | ESCC | 1.26e-02 | 1.30e-01 | 0.0662 |
374378 | GALNT18 | LZE22T | Human | Esophagus | ESCC | 1.40e-06 | 4.54e-01 | 0.068 |
374378 | GALNT18 | LZE24T | Human | Esophagus | ESCC | 5.74e-23 | 5.75e-01 | 0.0596 |
374378 | GALNT18 | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 2.10e-01 | 0.0875 |
374378 | GALNT18 | P2T-E | Human | Esophagus | ESCC | 3.13e-16 | 3.76e-01 | 0.1177 |
374378 | GALNT18 | P4T-E | Human | Esophagus | ESCC | 2.11e-11 | 2.61e-01 | 0.1323 |
374378 | GALNT18 | P5T-E | Human | Esophagus | ESCC | 1.18e-08 | 1.91e-01 | 0.1327 |
374378 | GALNT18 | P8T-E | Human | Esophagus | ESCC | 1.57e-23 | 4.75e-01 | 0.0889 |
374378 | GALNT18 | P9T-E | Human | Esophagus | ESCC | 3.67e-14 | 3.73e-01 | 0.1131 |
374378 | GALNT18 | P10T-E | Human | Esophagus | ESCC | 2.60e-47 | 9.07e-01 | 0.116 |
374378 | GALNT18 | P11T-E | Human | Esophagus | ESCC | 1.44e-21 | 7.85e-01 | 0.1426 |
374378 | GALNT18 | P12T-E | Human | Esophagus | ESCC | 2.72e-31 | 6.34e-01 | 0.1122 |
374378 | GALNT18 | P15T-E | Human | Esophagus | ESCC | 3.20e-25 | 5.53e-01 | 0.1149 |
374378 | GALNT18 | P16T-E | Human | Esophagus | ESCC | 2.09e-07 | 2.30e-01 | 0.1153 |
374378 | GALNT18 | P17T-E | Human | Esophagus | ESCC | 3.52e-10 | 3.61e-01 | 0.1278 |
374378 | GALNT18 | P19T-E | Human | Esophagus | ESCC | 3.75e-07 | 3.93e-01 | 0.1662 |
374378 | GALNT18 | P20T-E | Human | Esophagus | ESCC | 9.70e-23 | 3.94e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:0006493 | Lung | AIS | protein O-linked glycosylation | 17/1849 | 86/18723 | 4.04e-03 | 3.65e-02 | 17 |
GO:00064863 | Lung | AIS | protein glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
GO:00434133 | Lung | AIS | macromolecule glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:00064864 | Oral cavity | OSCC | protein glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00434134 | Oral cavity | OSCC | macromolecule glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00700853 | Oral cavity | OSCC | glycosylation | 117/7305 | 240/18723 | 1.29e-03 | 6.42e-03 | 117 |
GO:00064866 | Thyroid | PTC | protein glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00434136 | Thyroid | PTC | macromolecule glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT18 | SNV | Missense_Mutation | rs776435470 | c.718N>G | p.Arg240Gly | p.R240G | Q6P9A2 | protein_coding | deleterious(0.04) | possibly_damaging(0.5) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
GALNT18 | SNV | Missense_Mutation | c.276N>A | p.Phe92Leu | p.F92L | Q6P9A2 | protein_coding | tolerated(0.19) | benign(0) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
GALNT18 | SNV | Missense_Mutation | rs779138760 | c.140N>T | p.Ala47Val | p.A47V | Q6P9A2 | protein_coding | tolerated(0.31) | benign(0) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
GALNT18 | SNV | Missense_Mutation | c.1450N>A | p.Asp484Asn | p.D484N | Q6P9A2 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A6-2675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GALNT18 | SNV | Missense_Mutation | rs771202198 | c.1369G>A | p.Val457Met | p.V457M | Q6P9A2 | protein_coding | deleterious(0.01) | benign(0.011) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GALNT18 | SNV | Missense_Mutation | c.514C>T | p.Arg172Cys | p.R172C | Q6P9A2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GALNT18 | SNV | Missense_Mutation | rs759784088 | c.1801G>A | p.Val601Ile | p.V601I | Q6P9A2 | protein_coding | tolerated(0.69) | benign(0) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GALNT18 | SNV | Missense_Mutation | c.88G>A | p.Gly30Ser | p.G30S | Q6P9A2 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GALNT18 | SNV | Missense_Mutation | c.704N>T | p.Arg235Met | p.R235M | Q6P9A2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GALNT18 | SNV | Missense_Mutation | c.11N>A | p.Thr4Asn | p.T4N | Q6P9A2 | protein_coding | tolerated(0.06) | benign(0.133) | TCGA-CK-5912-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
374378 | GALNT18 | NA | tocilizumab | TOCILIZUMAB | 27339827 | |
374378 | GALNT18 | NA | cisplatin | CISPLATIN | 27150640 |
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