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Gene: GALNT12 |
Gene summary for GALNT12 |
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Gene information | Species | Human | Gene symbol | GALNT12 | Gene ID | 79695 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 12 | |
Gene Alias | CRCS1 | |
Cytomap | 9q22.33 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8IXK2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79695 | GALNT12 | male-WTA | Human | Thyroid | PTC | 1.19e-14 | 1.31e-01 | 0.1037 |
79695 | GALNT12 | PTC01 | Human | Thyroid | PTC | 1.01e-04 | 2.49e-01 | 0.1899 |
79695 | GALNT12 | PTC04 | Human | Thyroid | PTC | 5.66e-12 | 3.04e-01 | 0.1927 |
79695 | GALNT12 | PTC05 | Human | Thyroid | PTC | 8.11e-25 | 8.11e-01 | 0.2065 |
79695 | GALNT12 | PTC06 | Human | Thyroid | PTC | 6.52e-28 | 7.21e-01 | 0.2057 |
79695 | GALNT12 | PTC07 | Human | Thyroid | PTC | 1.51e-20 | 4.63e-01 | 0.2044 |
79695 | GALNT12 | ATC09 | Human | Thyroid | ATC | 4.28e-02 | 1.61e-01 | 0.2871 |
79695 | GALNT12 | ATC13 | Human | Thyroid | ATC | 6.70e-13 | 1.81e-01 | 0.34 |
79695 | GALNT12 | ATC5 | Human | Thyroid | ATC | 2.34e-09 | 2.07e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064866 | Thyroid | PTC | protein glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00434136 | Thyroid | PTC | macromolecule glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00700855 | Thyroid | PTC | glycosylation | 96/5968 | 240/18723 | 4.57e-03 | 2.15e-02 | 96 |
GO:00091013 | Thyroid | PTC | glycoprotein biosynthetic process | 123/5968 | 317/18723 | 5.05e-03 | 2.33e-02 | 123 |
GO:00091003 | Thyroid | PTC | glycoprotein metabolic process | 147/5968 | 387/18723 | 5.87e-03 | 2.64e-02 | 147 |
GO:000648612 | Thyroid | ATC | protein glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:004341312 | Thyroid | ATC | macromolecule glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT12 | SNV | Missense_Mutation | novel | c.520N>T | p.Val174Leu | p.V174L | Q8IXK2 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GALNT12 | SNV | Missense_Mutation | novel | c.1660G>A | p.Glu554Lys | p.E554K | Q8IXK2 | protein_coding | tolerated(0.9) | benign(0.062) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GALNT12 | SNV | Missense_Mutation | novel | c.1112N>G | p.Tyr371Cys | p.Y371C | Q8IXK2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GALNT12 | SNV | Missense_Mutation | c.1210N>A | p.Leu404Met | p.L404M | Q8IXK2 | protein_coding | tolerated(0.11) | benign(0.07) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GALNT12 | SNV | Missense_Mutation | c.413N>A | p.Thr138Lys | p.T138K | Q8IXK2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-E9-A22G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
GALNT12 | SNV | Missense_Mutation | c.1634N>C | p.Lys545Thr | p.K545T | Q8IXK2 | protein_coding | tolerated(0.17) | benign(0.136) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
GALNT12 | insertion | Frame_Shift_Ins | novel | c.915_916insTGCAATTTCCCGATAGTTGTAATTCTTACCCCAGAGTGGTATTTCT | p.Arg306CysfsTer16 | p.R306Cfs*16 | Q8IXK2 | protein_coding | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
GALNT12 | insertion | Nonsense_Mutation | novel | c.1015_1016insTCCAGGGACATTTAGAAGCATAGAG | p.Asn339IlefsTer8 | p.N339Ifs*8 | Q8IXK2 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
GALNT12 | deletion | Frame_Shift_Del | novel | c.949_952delNNNN | p.Ser318ArgfsTer92 | p.S318Rfs*92 | Q8IXK2 | protein_coding | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | ||
GALNT12 | deletion | Frame_Shift_Del | novel | c.1209delN | p.Leu404TrpfsTer7 | p.L404Wfs*7 | Q8IXK2 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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