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Gene: GAK |
Gene summary for GAK |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GAK | Gene ID | 2580 |
| Gene name | cyclin G associated kinase | |
| Gene Alias | DNAJ26 | |
| Cytomap | 4p16.3 | |
| Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | B4DS37 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2580 | GAK | HTA11_347_2000001011 | Human | Colorectum | AD | 4.18e-06 | 4.77e-01 | -0.1954 |
| 2580 | GAK | HTA11_696_2000001011 | Human | Colorectum | AD | 7.09e-10 | 5.31e-01 | -0.1464 |
| 2580 | GAK | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.14e-03 | 1.13e-01 | 0.0528 |
| 2580 | GAK | A015-C-203 | Human | Colorectum | FAP | 1.07e-15 | 1.46e-01 | -0.1294 |
| 2580 | GAK | A015-C-204 | Human | Colorectum | FAP | 2.01e-03 | 5.05e-02 | -0.0228 |
| 2580 | GAK | A002-C-201 | Human | Colorectum | FAP | 8.21e-09 | 1.77e-01 | 0.0324 |
| 2580 | GAK | A001-C-119 | Human | Colorectum | FAP | 1.90e-05 | 2.65e-01 | -0.1557 |
| 2580 | GAK | A001-C-108 | Human | Colorectum | FAP | 3.36e-10 | 2.26e-01 | -0.0272 |
| 2580 | GAK | A002-C-205 | Human | Colorectum | FAP | 6.40e-16 | 1.68e-01 | -0.1236 |
| 2580 | GAK | A001-C-104 | Human | Colorectum | FAP | 3.80e-02 | 2.41e-01 | 0.0184 |
| 2580 | GAK | A015-C-006 | Human | Colorectum | FAP | 2.84e-14 | 3.51e-01 | -0.0994 |
| 2580 | GAK | A015-C-106 | Human | Colorectum | FAP | 9.57e-12 | 2.35e-01 | -0.0511 |
| 2580 | GAK | A002-C-114 | Human | Colorectum | FAP | 6.64e-15 | 2.53e-01 | -0.1561 |
| 2580 | GAK | A015-C-104 | Human | Colorectum | FAP | 3.46e-24 | 2.90e-01 | -0.1899 |
| 2580 | GAK | A001-C-014 | Human | Colorectum | FAP | 1.74e-07 | 9.13e-02 | 0.0135 |
| 2580 | GAK | A002-C-016 | Human | Colorectum | FAP | 5.86e-14 | 1.79e-02 | 0.0521 |
| 2580 | GAK | A015-C-002 | Human | Colorectum | FAP | 7.65e-09 | 2.05e-01 | -0.0763 |
| 2580 | GAK | A001-C-203 | Human | Colorectum | FAP | 2.29e-08 | 1.70e-01 | -0.0481 |
| 2580 | GAK | A002-C-116 | Human | Colorectum | FAP | 1.86e-19 | -2.06e-01 | -0.0452 |
| 2580 | GAK | A014-C-008 | Human | Colorectum | FAP | 6.04e-12 | 2.65e-01 | -0.191 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
| GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
| GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
| GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
| GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
| GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
| GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
| GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
| GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
| GO:0072583 | Colorectum | AD | clathrin-dependent endocytosis | 24/3918 | 47/18723 | 4.60e-06 | 1.22e-04 | 24 |
| GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
| GO:0007041 | Colorectum | AD | lysosomal transport | 42/3918 | 114/18723 | 6.61e-05 | 1.07e-03 | 42 |
| GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
| GO:0006458 | Colorectum | AD | 'de novo' protein folding | 20/3918 | 43/18723 | 1.53e-04 | 2.16e-03 | 20 |
| GO:0071709 | Colorectum | AD | membrane assembly | 22/3918 | 50/18723 | 2.00e-04 | 2.66e-03 | 22 |
| GO:0051084 | Colorectum | AD | 'de novo' posttranslational protein folding | 18/3918 | 39/18723 | 3.66e-04 | 4.24e-03 | 18 |
| GO:0061077 | Colorectum | AD | chaperone-mediated protein folding | 26/3918 | 67/18723 | 6.20e-04 | 6.48e-03 | 26 |
| GO:0043624 | Colorectum | AD | cellular protein complex disassembly | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
| GO:0031345 | Colorectum | AD | negative regulation of cell projection organization | 58/3918 | 186/18723 | 6.37e-04 | 6.58e-03 | 58 |
| GO:0051261 | Colorectum | AD | protein depolymerization | 39/3918 | 114/18723 | 6.74e-04 | 6.91e-03 | 39 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GAK | SNV | Missense_Mutation | c.264N>A | p.Phe88Leu | p.F88L | O14976 | protein_coding | tolerated(0.12) | benign(0.046) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
| GAK | deletion | Frame_Shift_Del | novel | c.1400delN | p.Asn467ThrfsTer75 | p.N467Tfs*75 | O14976 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| GAK | deletion | Frame_Shift_Del | novel | c.3405delN | p.Lys1136SerfsTer20 | p.K1136Sfs*20 | O14976 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| GAK | SNV | Missense_Mutation | c.175N>C | p.Asp59His | p.D59H | O14976 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| GAK | SNV | Missense_Mutation | c.1273N>A | p.Glu425Lys | p.E425K | O14976 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| GAK | SNV | Missense_Mutation | c.790G>A | p.Glu264Lys | p.E264K | O14976 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
| GAK | SNV | Missense_Mutation | novel | c.3386N>A | p.Ala1129Asp | p.A1129D | O14976 | protein_coding | tolerated(0.46) | benign(0.028) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GAK | SNV | Missense_Mutation | novel | c.3242N>G | p.Asp1081Gly | p.D1081G | O14976 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GAK | SNV | Missense_Mutation | novel | c.524A>G | p.Lys175Arg | p.K175R | O14976 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| GAK | SNV | Missense_Mutation | c.2249G>A | p.Gly750Glu | p.G750E | O14976 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | SB-202190 | SB-202190 | 22951114 | |
| 2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | HTS-466284 | CHEMBL261454 | 19035792 |
| 2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | 223366123 | BARICITINIB | |
| 2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | 178101952 |
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