![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GABRP |
Gene summary for GABRP |
![]() |
Gene information | Species | Human | Gene symbol | GABRP | Gene ID | 2568 |
Gene name | gamma-aminobutyric acid type A receptor subunit pi | |
Gene Alias | GABRP | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B4DTP4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2568 | GABRP | GSM4909281 | Human | Breast | IDC | 2.18e-37 | 8.37e-01 | 0.21 |
2568 | GABRP | GSM4909282 | Human | Breast | IDC | 2.49e-13 | 4.59e-01 | -0.0288 |
2568 | GABRP | GSM4909285 | Human | Breast | IDC | 1.25e-12 | 4.57e-01 | 0.21 |
2568 | GABRP | GSM4909286 | Human | Breast | IDC | 3.74e-08 | 3.43e-01 | 0.1081 |
2568 | GABRP | GSM4909287 | Human | Breast | IDC | 8.35e-09 | 4.84e-01 | 0.2057 |
2568 | GABRP | GSM4909290 | Human | Breast | IDC | 7.88e-13 | -3.97e-01 | 0.2096 |
2568 | GABRP | GSM4909291 | Human | Breast | IDC | 8.87e-08 | -3.88e-01 | 0.1753 |
2568 | GABRP | GSM4909293 | Human | Breast | IDC | 1.21e-09 | -3.06e-01 | 0.1581 |
2568 | GABRP | GSM4909294 | Human | Breast | IDC | 6.88e-12 | -3.46e-01 | 0.2022 |
2568 | GABRP | GSM4909295 | Human | Breast | IDC | 3.11e-16 | 7.86e-01 | 0.0898 |
2568 | GABRP | GSM4909296 | Human | Breast | IDC | 3.30e-11 | -3.34e-01 | 0.1524 |
2568 | GABRP | GSM4909297 | Human | Breast | IDC | 7.03e-12 | -3.14e-01 | 0.1517 |
2568 | GABRP | GSM4909298 | Human | Breast | IDC | 1.85e-06 | -2.56e-01 | 0.1551 |
2568 | GABRP | GSM4909299 | Human | Breast | IDC | 3.73e-12 | 4.71e-01 | 0.035 |
2568 | GABRP | GSM4909300 | Human | Breast | IDC | 3.36e-02 | 4.36e-01 | 0.0334 |
2568 | GABRP | GSM4909301 | Human | Breast | IDC | 1.24e-19 | -3.97e-01 | 0.1577 |
2568 | GABRP | GSM4909302 | Human | Breast | IDC | 1.48e-10 | -3.10e-01 | 0.1545 |
2568 | GABRP | GSM4909304 | Human | Breast | IDC | 1.82e-21 | -3.93e-01 | 0.1636 |
2568 | GABRP | GSM4909305 | Human | Breast | IDC | 2.99e-05 | 4.43e-01 | 0.0436 |
2568 | GABRP | GSM4909307 | Human | Breast | IDC | 9.54e-10 | -7.84e-03 | 0.1569 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00423912 | Breast | IDC | regulation of membrane potential | 49/1434 | 434/18723 | 4.04e-03 | 3.25e-02 | 49 |
GO:00423911 | Breast | DCIS | regulation of membrane potential | 47/1390 | 434/18723 | 5.87e-03 | 4.20e-02 | 47 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0472316 | Breast | Precancer | Retrograde endocannabinoid signaling | 25/684 | 148/8465 | 3.05e-04 | 2.47e-03 | 1.89e-03 | 25 |
hsa0472317 | Breast | Precancer | Retrograde endocannabinoid signaling | 25/684 | 148/8465 | 3.05e-04 | 2.47e-03 | 1.89e-03 | 25 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa0472319 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GABRP | SNV | Missense_Mutation | c.686N>G | p.Tyr229Cys | p.Y229C | O00591 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
GABRP | SNV | Missense_Mutation | c.1002N>C | p.Gln334His | p.Q334H | O00591 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
GABRP | SNV | Missense_Mutation | novel | c.1126N>T | p.Asp376Tyr | p.D376Y | O00591 | protein_coding | deleterious(0.05) | possibly_damaging(0.7) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GABRP | SNV | Missense_Mutation | c.319C>G | p.Leu107Val | p.L107V | O00591 | protein_coding | tolerated(0.06) | benign(0.361) | TCGA-ZJ-AAXD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
GABRP | SNV | Missense_Mutation | novel | c.244T>C | p.Tyr82His | p.Y82H | O00591 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GABRP | SNV | Missense_Mutation | rs759922376 | c.481N>G | p.Asn161Asp | p.N161D | O00591 | protein_coding | tolerated(0.64) | possibly_damaging(0.875) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABRP | SNV | Missense_Mutation | c.329N>A | p.Arg110His | p.R110H | O00591 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
GABRP | SNV | Missense_Mutation | rs752539770 | c.181N>A | p.Val61Ile | p.V61I | O00591 | protein_coding | deleterious(0.03) | benign(0.153) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
GABRP | SNV | Missense_Mutation | rs79061387 | c.598N>T | p.Arg200Cys | p.R200C | O00591 | protein_coding | deleterious(0.05) | probably_damaging(0.939) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GABRP | SNV | Missense_Mutation | novel | c.53N>T | p.Arg18Met | p.R18M | O00591 | protein_coding | tolerated(0.14) | possibly_damaging(0.839) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | positive modulator | CHEMBL1200602 | ||
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | EVT-201 | |||
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | positive modulator | CHEMBL1200982 | BUTABARBITAL SODIUM | |
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | ADINAZOLAM | ADINAZOLAM | ||
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | CHLORDIAZEPOXIDE | CHLORDIAZEPOXIDE | ||
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | positive modulator | CHEMBL1200802 | TALBUTAL | |
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | CLORAZEPATE | CLORAZEPIC ACID | ||
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | positive modulator | CHEMBL1200472 | QUAZEPAM | |
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | positive modulator | CHEMBL580 | LORAZEPAM | |
2568 | GABRP | DRUGGABLE GENOME, ION CHANNEL | QUAZEPAM | QUAZEPAM |
Page: 1 2 3 4 5 6 7 8 9 10 11 |