![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GABARAPL2 |
Gene summary for GABARAPL2 |
![]() |
Gene information | Species | Human | Gene symbol | GABARAPL2 | Gene ID | 11345 |
Gene name | GABA type A receptor associated protein like 2 | |
Gene Alias | ATG8 | |
Cytomap | 16q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | P60520 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11345 | GABARAPL2 | GSM4909280 | Human | Breast | Precancer | 9.92e-03 | -4.42e-01 | 0.0305 |
11345 | GABARAPL2 | GSM4909282 | Human | Breast | IDC | 2.32e-05 | 2.17e-01 | -0.0288 |
11345 | GABARAPL2 | GSM4909286 | Human | Breast | IDC | 2.90e-03 | -2.96e-01 | 0.1081 |
11345 | GABARAPL2 | GSM4909287 | Human | Breast | IDC | 1.27e-06 | -3.31e-01 | 0.2057 |
11345 | GABARAPL2 | GSM4909288 | Human | Breast | IDC | 8.64e-05 | -5.35e-01 | 0.0988 |
11345 | GABARAPL2 | GSM4909290 | Human | Breast | IDC | 7.37e-04 | -3.62e-01 | 0.2096 |
11345 | GABARAPL2 | GSM4909293 | Human | Breast | IDC | 1.72e-05 | -3.51e-01 | 0.1581 |
11345 | GABARAPL2 | GSM4909294 | Human | Breast | IDC | 3.64e-08 | -2.49e-01 | 0.2022 |
11345 | GABARAPL2 | GSM4909296 | Human | Breast | IDC | 7.59e-19 | -4.97e-01 | 0.1524 |
11345 | GABARAPL2 | GSM4909297 | Human | Breast | IDC | 2.26e-26 | -3.60e-01 | 0.1517 |
11345 | GABARAPL2 | GSM4909301 | Human | Breast | IDC | 2.76e-05 | 5.60e-02 | 0.1577 |
11345 | GABARAPL2 | GSM4909302 | Human | Breast | IDC | 4.98e-03 | -2.43e-01 | 0.1545 |
11345 | GABARAPL2 | GSM4909309 | Human | Breast | IDC | 1.91e-04 | -1.27e-01 | 0.0483 |
11345 | GABARAPL2 | GSM4909311 | Human | Breast | IDC | 3.10e-41 | -4.28e-01 | 0.1534 |
11345 | GABARAPL2 | GSM4909312 | Human | Breast | IDC | 1.31e-14 | -1.57e-01 | 0.1552 |
11345 | GABARAPL2 | GSM4909313 | Human | Breast | IDC | 2.48e-06 | -2.95e-01 | 0.0391 |
11345 | GABARAPL2 | GSM4909316 | Human | Breast | IDC | 5.14e-06 | 1.82e-01 | 0.21 |
11345 | GABARAPL2 | GSM4909318 | Human | Breast | IDC | 7.00e-04 | -3.51e-01 | 0.2031 |
11345 | GABARAPL2 | GSM4909319 | Human | Breast | IDC | 2.10e-63 | -3.56e-01 | 0.1563 |
11345 | GABARAPL2 | GSM4909320 | Human | Breast | IDC | 5.43e-11 | -2.42e-01 | 0.1575 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
GO:19033629 | Breast | Precancer | regulation of cellular protein catabolic process | 36/1080 | 255/18723 | 6.03e-07 | 2.55e-05 | 36 |
GO:00421769 | Breast | Precancer | regulation of protein catabolic process | 47/1080 | 391/18723 | 1.50e-06 | 5.58e-05 | 47 |
GO:19030509 | Breast | Precancer | regulation of proteolysis involved in cellular protein catabolic process | 31/1080 | 221/18723 | 4.10e-06 | 1.27e-04 | 31 |
GO:00313309 | Breast | Precancer | negative regulation of cellular catabolic process | 34/1080 | 262/18723 | 8.16e-06 | 2.20e-04 | 34 |
GO:00709725 | Breast | Precancer | protein localization to endoplasmic reticulum | 15/1080 | 74/18723 | 1.74e-05 | 4.17e-04 | 15 |
GO:19033638 | Breast | Precancer | negative regulation of cellular protein catabolic process | 14/1080 | 75/18723 | 8.54e-05 | 1.63e-03 | 14 |
GO:00098959 | Breast | Precancer | negative regulation of catabolic process | 36/1080 | 320/18723 | 9.92e-05 | 1.83e-03 | 36 |
GO:00611369 | Breast | Precancer | regulation of proteasomal protein catabolic process | 24/1080 | 187/18723 | 1.99e-04 | 3.14e-03 | 24 |
GO:00004226 | Breast | Precancer | autophagy of mitochondrion | 14/1080 | 81/18723 | 2.01e-04 | 3.16e-03 | 14 |
GO:00617266 | Breast | Precancer | mitochondrion disassembly | 14/1080 | 81/18723 | 2.01e-04 | 3.16e-03 | 14 |
GO:00316679 | Breast | Precancer | response to nutrient levels | 47/1080 | 474/18723 | 2.09e-04 | 3.27e-03 | 47 |
GO:00434624 | Breast | Precancer | regulation of ATPase activity | 10/1080 | 46/18723 | 2.38e-04 | 3.57e-03 | 10 |
GO:19030518 | Breast | Precancer | negative regulation of proteolysis involved in cellular protein catabolic process | 12/1080 | 64/18723 | 2.58e-04 | 3.83e-03 | 12 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00421779 | Breast | Precancer | negative regulation of protein catabolic process | 17/1080 | 121/18723 | 5.76e-04 | 7.28e-03 | 17 |
GO:00714969 | Breast | Precancer | cellular response to external stimulus | 33/1080 | 320/18723 | 9.01e-04 | 1.03e-02 | 33 |
GO:00316688 | Breast | Precancer | cellular response to extracellular stimulus | 27/1080 | 246/18723 | 1.02e-03 | 1.13e-02 | 27 |
GO:00092677 | Breast | Precancer | cellular response to starvation | 19/1080 | 156/18723 | 1.65e-03 | 1.67e-02 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0413717 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0413742 | Breast | DCIS | Mitophagy - animal | 17/846 | 72/8465 | 5.75e-04 | 4.42e-03 | 3.26e-03 | 17 |
hsa0413752 | Breast | DCIS | Mitophagy - animal | 17/846 | 72/8465 | 5.75e-04 | 4.42e-03 | 3.26e-03 | 17 |
hsa0413718 | Cervix | CC | Mitophagy - animal | 22/1267 | 72/8465 | 5.77e-04 | 2.75e-03 | 1.63e-03 | 22 |
hsa046213 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa0413719 | Cervix | CC | Mitophagy - animal | 22/1267 | 72/8465 | 5.77e-04 | 2.75e-03 | 1.63e-03 | 22 |
hsa0462112 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa04137 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041371 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041372 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041373 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041374 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
Page: 1 2 3 4 5 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GABARAPL2 | SNV | Missense_Mutation | rs747530890 | c.88N>T | p.Pro30Ser | p.P30S | P60520 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABARAPL2 | SNV | Missense_Mutation | c.27C>G | p.His9Gln | p.H9Q | P60520 | protein_coding | deleterious(0.02) | benign(0.086) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GABARAPL2 | SNV | Missense_Mutation | rs11556291 | c.152N>C | p.Val51Ala | p.V51A | P60520 | protein_coding | deleterious(0.03) | possibly_damaging(0.658) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GABARAPL2 | SNV | Missense_Mutation | novel | c.298G>T | p.Asp100Tyr | p.D100Y | P60520 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GABARAPL2 | SNV | Missense_Mutation | novel | c.200N>T | p.Arg67Met | p.R67M | P60520 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GABARAPL2 | SNV | Missense_Mutation | rs759465042 | c.286N>A | p.Glu96Lys | p.E96K | P60520 | protein_coding | tolerated(0.07) | benign(0.053) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABARAPL2 | SNV | Missense_Mutation | c.250G>T | p.Val84Phe | p.V84F | P60520 | protein_coding | deleterious(0.01) | possibly_damaging(0.772) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GABARAPL2 | SNV | Missense_Mutation | c.331N>A | p.Gly111Arg | p.G111R | P60520 | protein_coding | deleterious(0.03) | possibly_damaging(0.646) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GABARAPL2 | SNV | Missense_Mutation | novel | c.298G>T | p.Asp100Tyr | p.D100Y | P60520 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
GABARAPL2 | SNV | Missense_Mutation | novel | c.172G>A | p.Ala58Thr | p.A58T | P60520 | protein_coding | deleterious(0) | benign(0.221) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |