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Gene: G2E3 |
Gene summary for G2E3 |
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Gene information | Species | Human | Gene symbol | G2E3 | Gene ID | 55632 |
Gene name | G2/M-phase specific E3 ubiquitin protein ligase | |
Gene Alias | KIAA1333 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B4DL73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55632 | G2E3 | LZE4T | Human | Esophagus | ESCC | 1.01e-05 | 1.61e-01 | 0.0811 |
55632 | G2E3 | LZE5T | Human | Esophagus | ESCC | 3.19e-04 | 2.00e-01 | 0.0514 |
55632 | G2E3 | LZE8T | Human | Esophagus | ESCC | 1.52e-04 | 1.53e-01 | 0.067 |
55632 | G2E3 | LZE24T | Human | Esophagus | ESCC | 5.03e-15 | 2.37e-01 | 0.0596 |
55632 | G2E3 | P2T-E | Human | Esophagus | ESCC | 2.47e-16 | 3.73e-01 | 0.1177 |
55632 | G2E3 | P4T-E | Human | Esophagus | ESCC | 2.02e-13 | 4.22e-01 | 0.1323 |
55632 | G2E3 | P5T-E | Human | Esophagus | ESCC | 7.73e-15 | 3.06e-01 | 0.1327 |
55632 | G2E3 | P8T-E | Human | Esophagus | ESCC | 3.00e-39 | 6.68e-01 | 0.0889 |
55632 | G2E3 | P9T-E | Human | Esophagus | ESCC | 3.80e-09 | 1.97e-01 | 0.1131 |
55632 | G2E3 | P10T-E | Human | Esophagus | ESCC | 1.16e-22 | 5.33e-01 | 0.116 |
55632 | G2E3 | P11T-E | Human | Esophagus | ESCC | 9.94e-13 | 4.34e-01 | 0.1426 |
55632 | G2E3 | P12T-E | Human | Esophagus | ESCC | 1.36e-29 | 4.80e-01 | 0.1122 |
55632 | G2E3 | P15T-E | Human | Esophagus | ESCC | 3.40e-22 | 5.32e-01 | 0.1149 |
55632 | G2E3 | P16T-E | Human | Esophagus | ESCC | 1.19e-09 | 1.51e-01 | 0.1153 |
55632 | G2E3 | P17T-E | Human | Esophagus | ESCC | 1.42e-04 | 3.21e-01 | 0.1278 |
55632 | G2E3 | P19T-E | Human | Esophagus | ESCC | 1.24e-09 | 4.38e-01 | 0.1662 |
55632 | G2E3 | P20T-E | Human | Esophagus | ESCC | 5.49e-17 | 4.08e-01 | 0.1124 |
55632 | G2E3 | P21T-E | Human | Esophagus | ESCC | 7.66e-10 | 2.30e-01 | 0.1617 |
55632 | G2E3 | P22T-E | Human | Esophagus | ESCC | 2.28e-18 | 1.65e-01 | 0.1236 |
55632 | G2E3 | P23T-E | Human | Esophagus | ESCC | 2.52e-20 | 3.69e-01 | 0.108 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
G2E3 | SNV | Missense_Mutation | c.1574G>A | p.Gly525Glu | p.G525E | Q7L622 | protein_coding | deleterious(0.03) | probably_damaging(0.927) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
G2E3 | SNV | Missense_Mutation | c.1349N>T | p.Gly450Val | p.G450V | Q7L622 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
G2E3 | SNV | Missense_Mutation | c.2038N>C | p.Glu680Gln | p.E680Q | Q7L622 | protein_coding | tolerated(0.52) | benign(0.037) | TCGA-S3-AA0Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Ancillary | neulasta | CR | |
G2E3 | deletion | Frame_Shift_Del | rs751355614 | c.1081delA | p.Thr361LeufsTer16 | p.T361Lfs*16 | Q7L622 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
G2E3 | SNV | Missense_Mutation | novel | c.761N>G | p.Glu254Gly | p.E254G | Q7L622 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
G2E3 | SNV | Missense_Mutation | c.299N>A | p.Arg100Gln | p.R100Q | Q7L622 | protein_coding | tolerated(0.19) | probably_damaging(0.995) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
G2E3 | SNV | Missense_Mutation | novel | c.125N>G | p.Tyr42Cys | p.Y42C | Q7L622 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
G2E3 | SNV | Missense_Mutation | rs769828044 | c.482N>A | p.Arg161Gln | p.R161Q | Q7L622 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
G2E3 | SNV | Missense_Mutation | c.1296N>T | p.Lys432Asn | p.K432N | Q7L622 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
G2E3 | SNV | Missense_Mutation | c.127T>C | p.Tyr43His | p.Y43H | Q7L622 | protein_coding | deleterious(0) | benign(0.046) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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