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Gene: FYB2 |
Gene summary for FYB2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FYB2 | Gene ID | 199920 |
Gene name | FYN binding protein 2 | |
Gene Alias | ARAP | |
Cytomap | 1p32.2 | |
Gene Type | protein-coding | GO ID | GO:0002253 | UniProtAcc | Q5VWT5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
199920 | FYB2 | AEH-subject1 | Human | Endometrium | AEH | 1.45e-37 | 5.97e-01 | -0.3059 |
199920 | FYB2 | AEH-subject2 | Human | Endometrium | AEH | 5.65e-18 | 4.60e-01 | -0.2525 |
199920 | FYB2 | AEH-subject3 | Human | Endometrium | AEH | 7.12e-13 | 3.14e-01 | -0.2576 |
199920 | FYB2 | AEH-subject4 | Human | Endometrium | AEH | 3.20e-11 | 2.98e-01 | -0.2657 |
199920 | FYB2 | AEH-subject5 | Human | Endometrium | AEH | 3.87e-05 | 2.09e-01 | -0.2953 |
199920 | FYB2 | EEC-subject2 | Human | Endometrium | EEC | 1.44e-25 | 5.13e-01 | -0.2607 |
199920 | FYB2 | EEC-subject4 | Human | Endometrium | EEC | 1.82e-05 | 1.49e-01 | -0.2571 |
199920 | FYB2 | EEC-subject5 | Human | Endometrium | EEC | 3.29e-02 | 1.02e-01 | -0.249 |
199920 | FYB2 | GSM5276935 | Human | Endometrium | EEC | 8.23e-05 | 1.48e-01 | -0.123 |
199920 | FYB2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.03e-03 | 2.20e-01 | -0.1869 |
199920 | FYB2 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.87e-05 | 1.54e-01 | -0.1269 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Endometrium | AEH: Atypical endometrial hyperplasia | |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265914 | Endometrium | AEH | protein localization to plasma membrane | 63/2100 | 284/18723 | 7.58e-08 | 3.92e-06 | 63 |
GO:00072296 | Endometrium | AEH | integrin-mediated signaling pathway | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:19907789 | Endometrium | AEH | protein localization to cell periphery | 68/2100 | 333/18723 | 6.38e-07 | 2.38e-05 | 68 |
GO:00027645 | Endometrium | AEH | immune response-regulating signaling pathway | 76/2100 | 468/18723 | 5.76e-04 | 5.71e-03 | 76 |
GO:00508525 | Endometrium | AEH | T cell receptor signaling pathway | 26/2100 | 123/18723 | 1.03e-03 | 9.15e-03 | 26 |
GO:007265915 | Endometrium | EEC | protein localization to plasma membrane | 64/2168 | 284/18723 | 1.05e-07 | 5.05e-06 | 64 |
GO:000722914 | Endometrium | EEC | integrin-mediated signaling pathway | 32/2168 | 107/18723 | 2.58e-07 | 1.10e-05 | 32 |
GO:199077814 | Endometrium | EEC | protein localization to cell periphery | 69/2168 | 333/18723 | 9.71e-07 | 3.31e-05 | 69 |
GO:000276412 | Endometrium | EEC | immune response-regulating signaling pathway | 80/2168 | 468/18723 | 2.20e-04 | 2.64e-03 | 80 |
GO:005085212 | Endometrium | EEC | T cell receptor signaling pathway | 26/2168 | 123/18723 | 1.64e-03 | 1.29e-02 | 26 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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