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Gene: FTX |
Gene summary for FTX |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FTX | Gene ID | 100302692 |
| Gene name | FTX transcript, XIST regulator | |
| Gene Alias | LINC00182 | |
| Cytomap | Xq13.2 | |
| Gene Type | ncRNA | GO ID | GO:0008150 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100302692 | FTX | CCI_1 | Human | Cervix | CC | 4.21e-30 | 1.74e+00 | 0.528 |
| 100302692 | FTX | CCI_2 | Human | Cervix | CC | 7.48e-40 | 2.24e+00 | 0.5249 |
| 100302692 | FTX | CCI_3 | Human | Cervix | CC | 1.49e-65 | 2.27e+00 | 0.516 |
| 100302692 | FTX | CCII_1 | Human | Cervix | CC | 5.40e-35 | 8.49e-01 | 0.3249 |
| 100302692 | FTX | sample1 | Human | Cervix | CC | 1.78e-08 | 3.05e-01 | 0.0959 |
| 100302692 | FTX | sample3 | Human | Cervix | CC | 4.93e-29 | 4.34e-01 | 0.1387 |
| 100302692 | FTX | H2 | Human | Cervix | HSIL_HPV | 2.75e-23 | 4.34e-01 | 0.0632 |
| 100302692 | FTX | L1 | Human | Cervix | CC | 1.60e-05 | 2.40e-01 | 0.0802 |
| 100302692 | FTX | T1 | Human | Cervix | CC | 6.01e-17 | 3.69e-01 | 0.0918 |
| 100302692 | FTX | T2 | Human | Cervix | CC | 8.06e-10 | 4.02e-01 | 0.0709 |
| 100302692 | FTX | T3 | Human | Cervix | CC | 1.21e-28 | 4.05e-01 | 0.1389 |
| 100302692 | FTX | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.33e-06 | -3.06e-01 | 0.0155 |
| 100302692 | FTX | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.99e-02 | -3.68e-01 | -0.1808 |
| 100302692 | FTX | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.49e-06 | 4.61e-01 | -0.0811 |
| 100302692 | FTX | HTA11_411_2000001011 | Human | Colorectum | SER | 9.35e-08 | -4.80e-01 | -0.2602 |
| 100302692 | FTX | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.20e-06 | -6.58e-01 | -0.2196 |
| 100302692 | FTX | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.87e-05 | -4.61e-01 | -0.1207 |
| 100302692 | FTX | HTA11_83_2000001011 | Human | Colorectum | SER | 2.73e-15 | -5.54e-01 | -0.1526 |
| 100302692 | FTX | HTA11_696_2000001011 | Human | Colorectum | AD | 6.57e-06 | -3.43e-01 | -0.1464 |
| 100302692 | FTX | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-05 | -7.25e-01 | -0.1706 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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