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Gene: FSIP2 |
Gene summary for FSIP2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FSIP2 | Gene ID | 401024 |
Gene name | fibrous sheath interacting protein 2 | |
Gene Alias | SPGF34 | |
Cytomap | 2q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q5CZC0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401024 | FSIP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.93e-02 | 7.74e-02 | 0.0155 |
401024 | FSIP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.63e-05 | 5.39e-01 | -0.1088 |
401024 | FSIP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.40e-09 | 4.97e-01 | 0.0674 |
401024 | FSIP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.98e-04 | 3.12e-01 | 0.294 |
401024 | FSIP2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.67e-05 | 6.67e-01 | 0.281 |
401024 | FSIP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.76e-02 | 3.74e-01 | 0.3859 |
401024 | FSIP2 | CRC-3-11773 | Human | Colorectum | CRC | 9.36e-06 | -2.06e-01 | 0.2564 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FSIP2 | SNV | Missense_Mutation | novel | c.17434T>C | p.Cys5812Arg | p.C5812R | Q5CZC0 | protein_coding | benign(0.138) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
FSIP2 | SNV | Missense_Mutation | novel | c.16892N>A | p.Ser5631Tyr | p.S5631Y | Q5CZC0 | protein_coding | benign(0.005) | TCGA-A7-A3IY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
FSIP2 | SNV | Missense_Mutation | novel | c.19584A>C | p.Lys6528Asn | p.K6528N | Q5CZC0 | protein_coding | possibly_damaging(0.858) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
FSIP2 | SNV | Missense_Mutation | c.19487N>A | p.Ala6496Asp | p.A6496D | Q5CZC0 | protein_coding | possibly_damaging(0.595) | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
FSIP2 | SNV | Missense_Mutation | novel | c.6944N>T | p.Ser2315Leu | p.S2315L | Q5CZC0 | protein_coding | benign(0) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FSIP2 | SNV | Missense_Mutation | novel | c.6902N>T | p.Asp2301Val | p.D2301V | Q5CZC0 | protein_coding | benign(0.003) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FSIP2 | SNV | Missense_Mutation | novel | c.20050G>A | p.Glu6684Lys | p.E6684K | Q5CZC0 | protein_coding | benign(0.018) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FSIP2 | SNV | Missense_Mutation | rs762359522 | c.17662N>A | p.Asp5888Asn | p.D5888N | Q5CZC0 | protein_coding | benign(0.046) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FSIP2 | SNV | Missense_Mutation | c.18583N>G | p.Pro6195Ala | p.P6195A | Q5CZC0 | protein_coding | possibly_damaging(0.821) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
FSIP2 | SNV | Missense_Mutation | novel | c.15661A>G | p.Ser5221Gly | p.S5221G | Q5CZC0 | protein_coding | benign(0.302) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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