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Gene: FRMD3 |
Gene summary for FRMD3 |
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Gene information | Species | Human | Gene symbol | FRMD3 | Gene ID | 257019 |
Gene name | FERM domain containing 3 | |
Gene Alias | 4.1O | |
Cytomap | 9q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A2A2Y4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
257019 | FRMD3 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.16e-07 | 4.16e-01 | -0.1088 |
257019 | FRMD3 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.20e-07 | 1.68e+00 | -0.2602 |
257019 | FRMD3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.26e-16 | 1.58e+00 | -0.2196 |
257019 | FRMD3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.99e-10 | 5.82e-01 | -0.1464 |
257019 | FRMD3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.59e-03 | 4.61e-01 | -0.2061 |
257019 | FRMD3 | male-WTA | Human | Thyroid | PTC | 2.80e-43 | 5.60e-01 | 0.1037 |
257019 | FRMD3 | female-WTA | Human | Thyroid | PTC | 4.60e-03 | 5.46e-01 | 0.0726 |
257019 | FRMD3 | PTC01 | Human | Thyroid | PTC | 3.12e-37 | 1.09e+00 | 0.1899 |
257019 | FRMD3 | PTC04 | Human | Thyroid | PTC | 1.22e-28 | 8.36e-01 | 0.1927 |
257019 | FRMD3 | PTC05 | Human | Thyroid | PTC | 1.41e-22 | 1.43e+00 | 0.2065 |
257019 | FRMD3 | PTC06 | Human | Thyroid | PTC | 5.49e-45 | 1.72e+00 | 0.2057 |
257019 | FRMD3 | PTC07 | Human | Thyroid | PTC | 1.39e-77 | 1.45e+00 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031032 | Colorectum | AD | actomyosin structure organization | 65/3918 | 196/18723 | 4.17e-05 | 7.37e-04 | 65 |
GO:00310321 | Colorectum | SER | actomyosin structure organization | 45/2897 | 196/18723 | 3.60e-03 | 3.03e-02 | 45 |
GO:0031032110 | Thyroid | PTC | actomyosin structure organization | 91/5968 | 196/18723 | 1.35e-05 | 1.45e-04 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FRMD3 | SNV | Missense_Mutation | c.1288G>A | p.Glu430Lys | p.E430K | A2A2Y4 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
FRMD3 | SNV | Missense_Mutation | c.1753N>T | p.Gly585Trp | p.G585W | A2A2Y4 | protein_coding | deleterious(0) | benign(0.319) | TCGA-AC-A4ZE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FRMD3 | SNV | Missense_Mutation | c.1679G>A | p.Cys560Tyr | p.C560Y | A2A2Y4 | protein_coding | tolerated(0.23) | benign(0.027) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FRMD3 | SNV | Missense_Mutation | rs111374752 | c.517N>G | p.Ile173Val | p.I173V | A2A2Y4 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FRMD3 | SNV | Missense_Mutation | novel | c.1165N>C | p.Glu389Gln | p.E389Q | A2A2Y4 | protein_coding | tolerated(0.24) | benign(0.033) | TCGA-AR-A2LL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
FRMD3 | insertion | Frame_Shift_Ins | novel | c.996_997insGGGCTGGT | p.Tyr333GlyfsTer40 | p.Y333Gfs*40 | A2A2Y4 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
FRMD3 | insertion | Nonsense_Mutation | novel | c.994_995insAGAGGCCCAGTGAGAGGGCTGTAGCTTGGTGAGCC | p.Arg332GlnfsTer11 | p.R332Qfs*11 | A2A2Y4 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
FRMD3 | SNV | Missense_Mutation | c.1789T>C | p.Ser597Pro | p.S597P | A2A2Y4 | protein_coding | deleterious_low_confidence(0) | benign(0.276) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FRMD3 | deletion | Frame_Shift_Del | novel | c.1156delN | p.Ser386ProfsTer27 | p.S386Pfs*27 | A2A2Y4 | protein_coding | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
FRMD3 | SNV | Missense_Mutation | c.8N>T | p.Ala3Val | p.A3V | A2A2Y4 | protein_coding | deleterious_low_confidence(0.02) | benign(0.027) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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