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Gene: FRAT2 |
Gene summary for FRAT2 |
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Gene information | Species | Human | Gene symbol | FRAT2 | Gene ID | 23401 |
Gene name | FRAT regulator of WNT signaling pathway 2 | |
Gene Alias | FRAT-2 | |
Cytomap | 10q24.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O75474 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23401 | FRAT2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.13e-08 | 2.14e-01 | 0.0155 |
23401 | FRAT2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.74e-04 | 1.93e-01 | -0.1808 |
23401 | FRAT2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.77e-05 | 3.16e-01 | -0.0811 |
23401 | FRAT2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.38e-12 | 3.39e-01 | -0.1088 |
23401 | FRAT2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.07e-24 | 5.09e-01 | -0.1954 |
23401 | FRAT2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.12e-08 | 3.16e-01 | -0.1207 |
23401 | FRAT2 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.60e-04 | 2.57e-01 | -0.1526 |
23401 | FRAT2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.18e-12 | 3.44e-01 | -0.1464 |
23401 | FRAT2 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.45e-07 | 2.50e-01 | -0.1001 |
23401 | FRAT2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.04e-17 | 5.50e-01 | -0.059 |
23401 | FRAT2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.46e-08 | 4.09e-01 | -0.1706 |
23401 | FRAT2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.55e-11 | 4.46e-01 | -0.2061 |
23401 | FRAT2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.78e-02 | 2.67e-01 | -0.1462 |
23401 | FRAT2 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.35e-07 | 2.47e-01 | -0.0842 |
23401 | FRAT2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.26e-02 | 2.21e-01 | -0.0179 |
23401 | FRAT2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.45e-17 | 4.02e-01 | 0.096 |
23401 | FRAT2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.87e-02 | 2.67e-01 | 0.0446 |
23401 | FRAT2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.25e-07 | 3.52e-01 | 0.0528 |
23401 | FRAT2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.37e-05 | 3.70e-01 | 0.0131 |
23401 | FRAT2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.24e-05 | 3.39e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:01987381 | Colorectum | SER | cell-cell signaling by wnt | 97/2897 | 446/18723 | 2.39e-04 | 4.11e-03 | 97 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:001605510 | Oral cavity | OSCC | Wnt signaling pathway | 227/7305 | 444/18723 | 1.10e-07 | 1.87e-06 | 227 |
GO:019873810 | Oral cavity | OSCC | cell-cell signaling by wnt | 227/7305 | 446/18723 | 1.75e-07 | 2.86e-06 | 227 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05225 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa052251 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa043101 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050223 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050104 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050224 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa052252 | Colorectum | MSS | Hepatocellular carcinoma | 56/1875 | 168/8465 | 5.04e-04 | 3.45e-03 | 2.11e-03 | 56 |
hsa043102 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa050105 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050225 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa052253 | Colorectum | MSS | Hepatocellular carcinoma | 56/1875 | 168/8465 | 5.04e-04 | 3.45e-03 | 2.11e-03 | 56 |
hsa043103 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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