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Gene: FOXS1 |
Gene summary for FOXS1 |
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Gene information | Species | Human | Gene symbol | FOXS1 | Gene ID | 2307 |
Gene name | forkhead box S1 | |
Gene Alias | FKHL18 | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O43638 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2307 | FOXS1 | ATC12 | Human | Thyroid | ATC | 2.61e-10 | 3.75e-01 | 0.34 |
2307 | FOXS1 | ATC13 | Human | Thyroid | ATC | 2.29e-68 | 1.74e+00 | 0.34 |
2307 | FOXS1 | ATC4 | Human | Thyroid | ATC | 2.55e-14 | 4.66e-01 | 0.34 |
2307 | FOXS1 | ATC5 | Human | Thyroid | ATC | 1.60e-74 | 1.81e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109022 | Thyroid | ATC | regulation of DNA-binding transcription factor activity | 190/6293 | 440/18723 | 1.49e-05 | 1.39e-04 | 190 |
GO:003526414 | Thyroid | ATC | multicellular organism growth | 61/6293 | 132/18723 | 1.73e-03 | 8.66e-03 | 61 |
GO:004863815 | Thyroid | ATC | regulation of developmental growth | 136/6293 | 330/18723 | 2.17e-03 | 1.02e-02 | 136 |
GO:00434333 | Thyroid | ATC | negative regulation of DNA-binding transcription factor activity | 79/6293 | 185/18723 | 5.96e-03 | 2.40e-02 | 79 |
GO:004592720 | Thyroid | ATC | positive regulation of growth | 106/6293 | 259/18723 | 7.90e-03 | 3.06e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
FOXS1 | M1MAC | Esophagus | ADJ | C20orf194,RP11-473M20.9,METTL22, etc. | 2.24e-01 | ![]() |
FOXS1 | iATC | Thyroid | HT | PLAC9,COL3A1,SPARC, etc. | 4.12e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXS1 | SNV | Missense_Mutation | novel | c.361N>C | p.Glu121Gln | p.E121Q | O43638 | protein_coding | tolerated(0.17) | benign(0.019) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FOXS1 | SNV | Missense_Mutation | rs377266974 | c.968C>T | p.Thr323Met | p.T323M | O43638 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXS1 | SNV | Missense_Mutation | c.578N>G | p.Lys193Arg | p.K193R | O43638 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FOXS1 | SNV | Missense_Mutation | rs776132794 | c.241N>T | p.Arg81Cys | p.R81C | O43638 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
FOXS1 | SNV | Missense_Mutation | rs777843574 | c.167N>A | p.Arg56His | p.R56H | O43638 | protein_coding | tolerated(0.14) | probably_damaging(0.999) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FOXS1 | SNV | Missense_Mutation | rs769718614 | c.950N>A | p.Thr317Asn | p.T317N | O43638 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXS1 | SNV | Missense_Mutation | novel | c.661C>A | p.Pro221Thr | p.P221T | O43638 | protein_coding | deleterious(0) | benign(0.1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOXS1 | SNV | Missense_Mutation | rs770771838 | c.242G>A | p.Arg81His | p.R81H | O43638 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOXS1 | SNV | Missense_Mutation | c.672N>A | p.Phe224Leu | p.F224L | O43638 | protein_coding | tolerated(0.05) | benign(0.275) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
FOXS1 | SNV | Missense_Mutation | rs201517755 | c.622G>A | p.Val208Met | p.V208M | O43638 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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