|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: FOXJ1 |
Gene summary for FOXJ1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FOXJ1 | Gene ID | 2302 |
| Gene name | forkhead box J1 | |
| Gene Alias | CILD43 | |
| Cytomap | 17q25.1 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R8P1 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2302 | FOXJ1 | LZE24T | Human | Esophagus | ESCC | 7.65e-05 | 6.51e-01 | 0.0596 |
| 2302 | FOXJ1 | P31T-E | Human | Esophagus | ESCC | 4.30e-09 | 1.90e-01 | 0.1251 |
| 2302 | FOXJ1 | P37T-E | Human | Esophagus | ESCC | 1.53e-03 | 9.97e-02 | 0.1371 |
| 2302 | FOXJ1 | P56T-E | Human | Esophagus | ESCC | 1.75e-02 | 2.42e-01 | 0.1613 |
| 2302 | FOXJ1 | P61T-E | Human | Esophagus | ESCC | 6.37e-05 | 1.64e-01 | 0.099 |
| 2302 | FOXJ1 | P74T-E | Human | Esophagus | ESCC | 4.21e-29 | 7.72e-01 | 0.1479 |
| 2302 | FOXJ1 | P82T-E | Human | Esophagus | ESCC | 6.28e-04 | 2.60e-01 | 0.1072 |
| 2302 | FOXJ1 | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 5.11e-01 | 0.1828 |
| 2302 | FOXJ1 | P130T-E | Human | Esophagus | ESCC | 3.66e-17 | 4.27e-01 | 0.1676 |
| 2302 | FOXJ1 | HCC1_Meng | Human | Liver | HCC | 1.10e-12 | 3.99e-02 | 0.0246 |
| 2302 | FOXJ1 | S014 | Human | Liver | HCC | 4.34e-21 | 6.15e-01 | 0.2254 |
| 2302 | FOXJ1 | S015 | Human | Liver | HCC | 6.11e-23 | 8.83e-01 | 0.2375 |
| 2302 | FOXJ1 | S016 | Human | Liver | HCC | 3.57e-20 | 6.39e-01 | 0.2243 |
| 2302 | FOXJ1 | S027 | Human | Liver | HCC | 1.62e-09 | 6.89e-01 | 0.2446 |
| 2302 | FOXJ1 | S028 | Human | Liver | HCC | 2.09e-20 | 7.27e-01 | 0.2503 |
| 2302 | FOXJ1 | S029 | Human | Liver | HCC | 2.50e-18 | 6.96e-01 | 0.2581 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
| GO:003001018 | Esophagus | ESCC | establishment of cell polarity | 96/8552 | 143/18723 | 1.69e-07 | 2.67e-06 | 96 |
| GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
| GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
| GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
| GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
| GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
| GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
| GO:00611625 | Esophagus | ESCC | establishment of monopolar cell polarity | 20/8552 | 24/18723 | 1.69e-04 | 1.11e-03 | 20 |
| GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
| GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
| GO:00613394 | Esophagus | ESCC | establishment or maintenance of monopolar cell polarity | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
| GO:00350893 | Esophagus | ESCC | establishment of apical/basal cell polarity | 18/8552 | 22/18723 | 5.69e-04 | 3.10e-03 | 18 |
| GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
| GO:00604284 | Esophagus | ESCC | lung epithelium development | 27/8552 | 37/18723 | 7.00e-04 | 3.66e-03 | 27 |
| GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
| GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
| GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
| GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
| GO:0002467 | Esophagus | ESCC | germinal center formation | 12/8552 | 14/18723 | 2.51e-03 | 1.08e-02 | 12 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| FOXJ1 | CILIA | Endometrium | ADJ | ZMYND10,TSPAN1,CCDC78, etc. | 3.67e-01 |  |
| FOXJ1 | CILIA | Endometrium | AEH | ZMYND10,TSPAN1,CCDC78, etc. | 3.40e-01 |  |
| FOXJ1 | CILIA | Endometrium | EEC | ZMYND10,TSPAN1,CCDC78, etc. | 2.65e-01 |  |
| FOXJ1 | M1MAC | Endometrium | EEC | SCGB2A1,PDLIM1,WFDC2, etc. | 8.26e-02 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FOXJ1 | insertion | In_Frame_Ins | novel | c.974_975insCCAAGATTGCGCCACTAC | p.Gly325_Ala326insGlnAspCysAlaThrThr | p.G325_A326insQDCATT | Q92949 | protein_coding | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| FOXJ1 | deletion | Frame_Shift_Del | c.167delN | p.Gly56AlafsTer65 | p.G56Afs*65 | Q92949 | protein_coding | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |||
| FOXJ1 | SNV | Missense_Mutation | rs772479816 | c.686C>T | p.Ala229Val | p.A229V | Q92949 | protein_coding | tolerated(0.32) | benign(0.005) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| FOXJ1 | SNV | Missense_Mutation | rs770811479 | c.586N>T | p.Arg196Cys | p.R196C | Q92949 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| FOXJ1 | SNV | Missense_Mutation | c.610N>T | p.Arg204Trp | p.R204W | Q92949 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FOXJ1 | SNV | Missense_Mutation | rs202087312 | c.1015G>A | p.Ala339Thr | p.A339T | Q92949 | protein_coding | tolerated(0.21) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FOXJ1 | SNV | Missense_Mutation | novel | c.512N>G | p.His171Arg | p.H171R | Q92949 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FOXJ1 | SNV | Missense_Mutation | c.543A>C | p.Lys181Asn | p.K181N | Q92949 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| FOXJ1 | SNV | Missense_Mutation | novel | c.1205N>A | p.Ala402Asp | p.A402D | Q92949 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| FOXJ1 | deletion | Frame_Shift_Del | c.327delN | p.Asp110ThrfsTer11 | p.D110Tfs*11 | Q92949 | protein_coding | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |