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Gene: FOXD2 |
Gene summary for FOXD2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FOXD2 | Gene ID | 2306 |
| Gene name | forkhead box D2 | |
| Gene Alias | FKHL17 | |
| Cytomap | 1p33 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60548 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2306 | FOXD2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.38e-03 | 1.97e-01 | -0.1808 |
| 2306 | FOXD2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.85e-03 | 2.90e-01 | -0.0811 |
| 2306 | FOXD2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.39e-15 | 4.51e-01 | -0.1954 |
| 2306 | FOXD2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.49e-05 | 2.90e-01 | -0.1464 |
| 2306 | FOXD2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.02e-05 | 2.83e-01 | -0.059 |
| 2306 | FOXD2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.76e-04 | 4.25e-01 | -0.1706 |
| 2306 | FOXD2 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.32e-04 | 3.81e-01 | -0.0842 |
| 2306 | FOXD2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.88e-03 | 4.07e-01 | -0.0179 |
| 2306 | FOXD2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.83e-04 | 4.87e-01 | -0.0177 |
| 2306 | FOXD2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.71e-03 | 2.68e-01 | 0.0338 |
| 2306 | FOXD2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.84e-02 | 4.32e-01 | -0.0124 |
| 2306 | FOXD2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.58e-05 | 2.55e-01 | 0.294 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| FOXD2 | TUF | Colorectum | Healthy | OTUD3,AKR1B10,ABCA7, etc. | 4.16e-02 |  |
| FOXD2 | PERI | Thyroid | ATC | HOXB7,CTSW,ZNF316, etc. | 2.26e-01 |  |
| FOXD2 | SMC | Thyroid | ATC | HOXB7,CTSW,ZNF316, etc. | 1.69e-01 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FOXD2 | SNV | Missense_Mutation | c.450G>C | p.Leu150Phe | p.L150F | O60548 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| FOXD2 | SNV | Missense_Mutation | novel | c.658C>G | p.Arg220Gly | p.R220G | O60548 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| FOXD2 | SNV | Missense_Mutation | c.509C>T | p.Ala170Val | p.A170V | O60548 | protein_coding | deleterious(0.02) | possibly_damaging(0.573) | TCGA-3L-AA1B-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| FOXD2 | SNV | Missense_Mutation | c.1391N>T | p.Ala464Val | p.A464V | O60548 | protein_coding | deleterious_low_confidence(0.01) | benign(0.212) | TCGA-AU-3779-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FOXD2 | SNV | Missense_Mutation | novel | c.1454G>A | p.Ser485Asn | p.S485N | O60548 | protein_coding | deleterious_low_confidence(0.02) | benign(0.001) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
| FOXD2 | SNV | Missense_Mutation | c.556G>C | p.Val186Leu | p.V186L | O60548 | protein_coding | deleterious(0) | possibly_damaging(0.693) | TCGA-DD-A4ND-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
| FOXD2 | SNV | Missense_Mutation | novel | c.1163N>T | p.Arg388Leu | p.R388L | O60548 | protein_coding | tolerated_low_confidence(0.38) | benign(0.003) | TCGA-G3-AAV5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Chemotherapy | hec.1 | SD |
| FOXD2 | SNV | Missense_Mutation | novel | c.704N>A | p.Pro235Gln | p.P235Q | O60548 | protein_coding | tolerated_low_confidence(0.07) | benign(0.123) | TCGA-78-7148-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| FOXD2 | SNV | Missense_Mutation | novel | c.525C>G | p.Ile175Met | p.I175M | O60548 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NK-A5D1-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemcitabine | PD |
| FOXD2 | SNV | Missense_Mutation | novel | c.469N>G | p.Ile157Val | p.I157V | O60548 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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