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Gene: FNDC1 |
Gene summary for FNDC1 |
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Gene information | Species | Human | Gene symbol | FNDC1 | Gene ID | 84624 |
Gene name | fibronectin type III domain containing 1 | |
Gene Alias | AGS8 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q4ZHG4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84624 | FNDC1 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 3.08e-03 | -3.35e-01 | 0.02 |
84624 | FNDC1 | PTCwithHT_6 | Human | Thyroid | HT | 2.66e-05 | -3.41e-01 | 0.02 |
84624 | FNDC1 | PTCwithoutHT_2 | Human | Thyroid | PTC | 1.25e-05 | -3.47e-01 | 0.0419 |
84624 | FNDC1 | male-WTA | Human | Thyroid | PTC | 4.20e-32 | 1.18e-01 | 0.1037 |
84624 | FNDC1 | PTC03 | Human | Thyroid | PTC | 1.66e-02 | -2.21e-01 | 0.1784 |
84624 | FNDC1 | PTC06 | Human | Thyroid | PTC | 6.62e-06 | 6.28e-01 | 0.2057 |
84624 | FNDC1 | PTC07 | Human | Thyroid | PTC | 4.93e-20 | 8.79e-01 | 0.2044 |
84624 | FNDC1 | ATC12 | Human | Thyroid | ATC | 2.66e-05 | -3.47e-01 | 0.34 |
84624 | FNDC1 | ATC13 | Human | Thyroid | ATC | 3.45e-03 | 1.68e-01 | 0.34 |
84624 | FNDC1 | ATC4 | Human | Thyroid | ATC | 6.12e-04 | -3.47e-01 | 0.34 |
84624 | FNDC1 | ATC5 | Human | Thyroid | ATC | 1.19e-09 | 2.31e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FNDC1 | SNV | Missense_Mutation | novel | c.1367N>T | p.Thr456Ile | p.T456I | Q4ZHG4 | protein_coding | deleterious(0) | benign(0.049) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
FNDC1 | SNV | Missense_Mutation | c.815N>T | p.Ser272Leu | p.S272L | Q4ZHG4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
FNDC1 | SNV | Missense_Mutation | rs186515442 | c.895N>A | p.Val299Met | p.V299M | Q4ZHG4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
FNDC1 | SNV | Missense_Mutation | novel | c.5198N>C | p.Gln1733Pro | p.Q1733P | Q4ZHG4 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FNDC1 | SNV | Missense_Mutation | novel | c.5199N>T | p.Gln1733His | p.Q1733H | Q4ZHG4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FNDC1 | SNV | Missense_Mutation | rs267600879 | c.1576C>T | p.Arg526Cys | p.R526C | Q4ZHG4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.226) | TCGA-AC-A23E-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
FNDC1 | SNV | Missense_Mutation | rs747120622 | c.1579G>A | p.Ala527Thr | p.A527T | Q4ZHG4 | protein_coding | tolerated_low_confidence(0.17) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FNDC1 | SNV | Missense_Mutation | c.2299N>A | p.Val767Ile | p.V767I | Q4ZHG4 | protein_coding | deleterious_low_confidence(0.05) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FNDC1 | SNV | Missense_Mutation | c.2045G>A | p.Arg682His | p.R682H | Q4ZHG4 | protein_coding | tolerated_low_confidence(0.11) | benign(0.001) | TCGA-B6-A40B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FNDC1 | SNV | Missense_Mutation | c.2125N>A | p.Asp709Asn | p.D709N | Q4ZHG4 | protein_coding | tolerated_low_confidence(0.47) | benign(0.001) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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