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Gene: FMNL3 |
Gene summary for FMNL3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FMNL3 | Gene ID | 91010 |
| Gene name | formin like 3 | |
| Gene Alias | FHOD3 | |
| Cytomap | 12q13.12 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8IVF7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 91010 | FMNL3 | male-WTA | Human | Thyroid | PTC | 3.60e-09 | 1.30e-01 | 0.1037 |
| 91010 | FMNL3 | PTC04 | Human | Thyroid | PTC | 1.41e-05 | 1.02e-01 | 0.1927 |
| 91010 | FMNL3 | PTC06 | Human | Thyroid | PTC | 6.77e-03 | 1.43e-01 | 0.2057 |
| 91010 | FMNL3 | PTC07 | Human | Thyroid | PTC | 5.95e-07 | 1.19e-01 | 0.2044 |
| 91010 | FMNL3 | ATC09 | Human | Thyroid | ATC | 6.36e-03 | 2.12e-01 | 0.2871 |
| 91010 | FMNL3 | ATC11 | Human | Thyroid | ATC | 3.84e-02 | 3.51e-01 | 0.3386 |
| 91010 | FMNL3 | ATC12 | Human | Thyroid | ATC | 5.03e-18 | 4.23e-01 | 0.34 |
| 91010 | FMNL3 | ATC13 | Human | Thyroid | ATC | 4.14e-42 | 6.25e-01 | 0.34 |
| 91010 | FMNL3 | ATC1 | Human | Thyroid | ATC | 2.06e-04 | 2.64e-01 | 0.2878 |
| 91010 | FMNL3 | ATC4 | Human | Thyroid | ATC | 2.44e-23 | 5.74e-01 | 0.34 |
| 91010 | FMNL3 | ATC5 | Human | Thyroid | ATC | 1.15e-38 | 6.83e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022604112 | Thyroid | PTC | regulation of cell morphogenesis | 165/5968 | 309/18723 | 2.60e-15 | 1.82e-13 | 165 |
| GO:0008360111 | Thyroid | PTC | regulation of cell shape | 86/5968 | 154/18723 | 6.22e-10 | 1.95e-08 | 86 |
| GO:0030865110 | Thyroid | PTC | cortical cytoskeleton organization | 38/5968 | 61/18723 | 9.77e-07 | 1.46e-05 | 38 |
| GO:003086616 | Thyroid | PTC | cortical actin cytoskeleton organization | 25/5968 | 40/18723 | 6.51e-05 | 5.72e-04 | 25 |
| GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
| GO:000836026 | Thyroid | ATC | regulation of cell shape | 91/6293 | 154/18723 | 7.33e-11 | 2.31e-09 | 91 |
| GO:003086523 | Thyroid | ATC | cortical cytoskeleton organization | 41/6293 | 61/18723 | 8.28e-08 | 1.43e-06 | 41 |
| GO:003086617 | Thyroid | ATC | cortical actin cytoskeleton organization | 28/6293 | 40/18723 | 2.77e-06 | 3.19e-05 | 28 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FMNL3 | SNV | Missense_Mutation | novel | c.916N>A | p.Leu306Met | p.L306M | Q8IVF7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
| FMNL3 | SNV | Missense_Mutation | c.1537N>A | p.Glu513Lys | p.E513K | Q8IVF7 | protein_coding | tolerated(0.82) | benign(0.04) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| FMNL3 | SNV | Missense_Mutation | novel | c.1264N>T | p.Arg422Trp | p.R422W | Q8IVF7 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| FMNL3 | SNV | Missense_Mutation | c.783N>C | p.Lys261Asn | p.K261N | Q8IVF7 | protein_coding | tolerated(0.06) | probably_damaging(0.99) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| FMNL3 | SNV | Missense_Mutation | rs752122892 | c.2623A>G | p.Ser875Gly | p.S875G | Q8IVF7 | protein_coding | tolerated(0.3) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| FMNL3 | SNV | Missense_Mutation | c.1477G>C | p.Glu493Gln | p.E493Q | Q8IVF7 | protein_coding | tolerated(0.45) | benign(0.101) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FMNL3 | SNV | Missense_Mutation | rs371568850 | c.1679N>A | p.Arg560Gln | p.R560Q | Q8IVF7 | protein_coding | tolerated(0.09) | benign(0.176) | TCGA-E2-A15L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
| FMNL3 | SNV | Missense_Mutation | c.1969T>G | p.Ser657Ala | p.S657A | Q8IVF7 | protein_coding | tolerated(0.52) | benign(0.055) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
| FMNL3 | SNV | Missense_Mutation | c.373N>C | p.Val125Leu | p.V125L | Q8IVF7 | protein_coding | deleterious(0.01) | benign(0.24) | TCGA-OL-A5D8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| FMNL3 | insertion | Frame_Shift_Ins | novel | c.2341_2342insGTCCTACAAGTCCAACCAGTGGACCTGGAATTGGCCAAGGG | p.Lys781SerfsTer40 | p.K781Sfs*40 | Q8IVF7 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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