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Gene: FILIP1L |
Gene summary for FILIP1L |
Gene summary. |
Gene information | Species | Human | Gene symbol | FILIP1L | Gene ID | 11259 |
Gene name | filamin A interacting protein 1 like | |
Gene Alias | DOC-1 | |
Cytomap | 3q12.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q4L180 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11259 | FILIP1L | P4T-E | Human | Esophagus | ESCC | 5.50e-09 | 6.67e-01 | 0.1323 |
11259 | FILIP1L | P5T-E | Human | Esophagus | ESCC | 4.07e-04 | 3.75e-01 | 0.1327 |
11259 | FILIP1L | P9T-E | Human | Esophagus | ESCC | 8.87e-14 | 7.58e-01 | 0.1131 |
11259 | FILIP1L | P10T-E | Human | Esophagus | ESCC | 1.86e-19 | 5.05e-01 | 0.116 |
11259 | FILIP1L | P11T-E | Human | Esophagus | ESCC | 2.76e-08 | 5.74e-01 | 0.1426 |
11259 | FILIP1L | P19T-E | Human | Esophagus | ESCC | 7.89e-10 | 9.47e-01 | 0.1662 |
11259 | FILIP1L | P21T-E | Human | Esophagus | ESCC | 4.48e-12 | 4.00e-01 | 0.1617 |
11259 | FILIP1L | P24T-E | Human | Esophagus | ESCC | 3.20e-08 | 4.58e-01 | 0.1287 |
11259 | FILIP1L | P30T-E | Human | Esophagus | ESCC | 4.64e-03 | 5.77e-01 | 0.137 |
11259 | FILIP1L | P31T-E | Human | Esophagus | ESCC | 6.13e-26 | 6.35e-01 | 0.1251 |
11259 | FILIP1L | P32T-E | Human | Esophagus | ESCC | 3.77e-22 | 6.11e-01 | 0.1666 |
11259 | FILIP1L | P37T-E | Human | Esophagus | ESCC | 2.71e-17 | 6.33e-01 | 0.1371 |
11259 | FILIP1L | P40T-E | Human | Esophagus | ESCC | 3.71e-02 | 2.47e-01 | 0.109 |
11259 | FILIP1L | P42T-E | Human | Esophagus | ESCC | 4.13e-07 | 6.04e-01 | 0.1175 |
11259 | FILIP1L | P44T-E | Human | Esophagus | ESCC | 2.16e-10 | 6.84e-01 | 0.1096 |
11259 | FILIP1L | P47T-E | Human | Esophagus | ESCC | 2.37e-05 | 4.14e-01 | 0.1067 |
11259 | FILIP1L | P75T-E | Human | Esophagus | ESCC | 4.18e-02 | 1.74e-01 | 0.1125 |
11259 | FILIP1L | P83T-E | Human | Esophagus | ESCC | 5.45e-08 | 4.80e-01 | 0.1738 |
11259 | FILIP1L | P107T-E | Human | Esophagus | ESCC | 3.64e-18 | 7.39e-01 | 0.171 |
11259 | FILIP1L | P128T-E | Human | Esophagus | ESCC | 7.08e-05 | 6.10e-01 | 0.1241 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FILIP1L | SNV | Missense_Mutation | rs777759195 | c.1678N>A | p.Val560Ile | p.V560I | Q4L180 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-B6-A0WY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FILIP1L | SNV | Missense_Mutation | c.2981N>T | p.Thr994Ile | p.T994I | Q4L180 | protein_coding | tolerated(0.1) | probably_damaging(0.963) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
FILIP1L | deletion | Frame_Shift_Del | c.255_273delNNNNNNNNNNNNNNNNNNN | p.Arg86PhefsTer2 | p.R86Ffs*2 | Q4L180 | protein_coding | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |||
FILIP1L | SNV | Missense_Mutation | c.2598N>A | p.Met866Ile | p.M866I | Q4L180 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
FILIP1L | SNV | Missense_Mutation | c.2598N>A | p.Met866Ile | p.M866I | Q4L180 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FILIP1L | SNV | Missense_Mutation | c.955N>G | p.Gln319Glu | p.Q319E | Q4L180 | protein_coding | tolerated(0.07) | probably_damaging(0.952) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
FILIP1L | SNV | Missense_Mutation | novel | c.2191N>A | p.Ala731Thr | p.A731T | Q4L180 | protein_coding | tolerated(0.52) | possibly_damaging(0.505) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FILIP1L | SNV | Missense_Mutation | rs377075355 | c.3272N>A | p.Arg1091Gln | p.R1091Q | Q4L180 | protein_coding | tolerated(0.09) | probably_damaging(0.992) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FILIP1L | SNV | Missense_Mutation | novel | c.2345N>T | p.Arg782Met | p.R782M | Q4L180 | protein_coding | deleterious(0) | possibly_damaging(0.819) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FILIP1L | SNV | Missense_Mutation | novel | c.1427N>G | p.Glu476Gly | p.E476G | Q4L180 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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