Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FGGY

Gene summary for FGGY

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FGGY

Gene ID

55277

Gene nameFGGY carbohydrate kinase domain containing
Gene AliasFGGY
Cytomap1p32.1
Gene Typeprotein-coding
GO ID

GO:0005975

UniProtAcc

Q96C11


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
55277FGGYCCI_1HumanCervixCC1.71e-028.46e-010.528
55277FGGYCCI_3HumanCervixCC3.48e-055.20e-010.516
55277FGGYHTA11_3410_2000001011HumanColorectumAD7.79e-20-6.36e-010.0155
55277FGGYHTA11_2487_2000001011HumanColorectumSER3.63e-07-5.50e-01-0.1808
55277FGGYHTA11_78_2000001011HumanColorectumAD3.75e-05-5.15e-01-0.1088
55277FGGYHTA11_2112_2000001011HumanColorectumSER1.17e-02-8.01e-01-0.2196
55277FGGYHTA11_3361_2000001011HumanColorectumAD7.74e-11-7.56e-01-0.1207
55277FGGYHTA11_696_2000001011HumanColorectumAD8.13e-03-4.32e-01-0.1464
55277FGGYHTA11_866_2000001011HumanColorectumAD4.35e-03-3.87e-01-0.1001
55277FGGYHTA11_5212_2000001011HumanColorectumAD8.97e-05-7.76e-01-0.2061
55277FGGYHTA11_7862_2000001011HumanColorectumAD2.46e-05-7.25e-01-0.0179
55277FGGYHTA11_866_3004761011HumanColorectumAD5.03e-04-3.89e-010.096
55277FGGYHTA11_8622_2000001021HumanColorectumSER5.48e-04-6.86e-010.0528
55277FGGYHTA11_99999970781_79442HumanColorectumMSS3.24e-07-4.26e-010.294
55277FGGYHTA11_99999965062_69753HumanColorectumMSI-H1.95e-041.07e+000.3487
55277FGGYHTA11_99999971662_82457HumanColorectumMSS4.01e-04-4.03e-010.3859
55277FGGYHTA11_99999973899_84307HumanColorectumMSS1.34e-03-5.77e-010.2585
55277FGGYF007HumanColorectumFAP3.99e-032.45e-010.1176
55277FGGYA002-C-010HumanColorectumFAP3.61e-041.30e-010.242
55277FGGYA015-C-203HumanColorectumFAP7.87e-281.84e-01-0.1294
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00602498CervixCCanatomical structure homeostasis63/2311314/187236.03e-058.68e-0463
GO:0044262ColorectumADcellular carbohydrate metabolic process87/3918283/187236.00e-051.01e-0387
GO:0005996ColorectumADmonosaccharide metabolic process80/3918257/187237.31e-051.17e-0380
GO:0060249ColorectumADanatomical structure homeostasis94/3918314/187239.37e-051.42e-0394
GO:00602491ColorectumSERanatomical structure homeostasis74/2897314/187231.01e-042.13e-0374
GO:00059961ColorectumSERmonosaccharide metabolic process59/2897257/187239.65e-041.15e-0259
GO:00602492ColorectumMSSanatomical structure homeostasis84/3467314/187231.87e-042.64e-0384
GO:00059962ColorectumMSSmonosaccharide metabolic process66/3467257/187232.61e-032.06e-0266
GO:00602493ColorectumMSI-Hanatomical structure homeostasis38/1319314/187237.73e-041.44e-0238
GO:00442621ColorectumFAPcellular carbohydrate metabolic process66/2622283/187231.53e-054.01e-0466
GO:00059963ColorectumFAPmonosaccharide metabolic process59/2622257/187236.79e-051.28e-0359
GO:00602494ColorectumFAPanatomical structure homeostasis69/2622314/187237.51e-051.37e-0369
GO:00602495ColorectumCRCanatomical structure homeostasis57/2078314/187231.24e-042.41e-0357
GO:00442622ColorectumCRCcellular carbohydrate metabolic process49/2078283/187231.06e-031.24e-0249
GO:00059965LiverNAFLDmonosaccharide metabolic process53/1882257/187232.89e-071.92e-0553
GO:00442623LiverNAFLDcellular carbohydrate metabolic process55/1882283/187231.27e-066.01e-0555
GO:000599612LiverCirrhoticmonosaccharide metabolic process104/4634257/187231.74e-086.32e-07104
GO:004426211LiverCirrhoticcellular carbohydrate metabolic process97/4634283/187231.89e-041.76e-0397
GO:000599621LiverHCCmonosaccharide metabolic process167/7958257/187232.31e-131.25e-11167
GO:004426221LiverHCCcellular carbohydrate metabolic process153/7958283/187235.27e-055.00e-04153
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FGGYSNVMissense_Mutationc.597N>Cp.Glu199Aspp.E199DQ96C11protein_codingtolerated(0.39)benign(0.001)TCGA-D8-A27G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
FGGYSNVMissense_Mutationc.1522N>Gp.Ser508Alap.S508AQ96C11protein_codingtolerated(0.49)benign(0.101)TCGA-E9-A22E-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphaneSD
FGGYSNVMissense_Mutationc.569N>Cp.Leu190Prop.L190PQ96C11protein_codingdeleterious(0.01)probably_damaging(0.97)TCGA-AA-3663-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
FGGYSNVMissense_Mutationrs773705363c.166G>Ap.Glu56Lysp.E56KQ96C11protein_codingtolerated(0.09)benign(0.063)TCGA-AA-3977-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
FGGYSNVMissense_Mutationc.35A>Gp.Tyr12Cysp.Y12CQ96C11protein_codingdeleterious(0)probably_damaging(0.987)TCGA-CM-4743-01Colorectumcolon adenocarcinomaMale>=65I/IIChemotherapycapecitabineSD
FGGYSNVMissense_Mutationrs747128652c.1247N>Tp.Pro416Leup.P416LQ96C11protein_codingtolerated_low_confidence(0.27)benign(0.007)TCGA-CM-6678-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfluorouracilSD
FGGYSNVMissense_Mutationnovelc.1250N>Ap.Ala417Aspp.A417DQ96C11protein_codingtolerated_low_confidence(0.65)benign(0.367)TCGA-D5-6928-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
FGGYSNVMissense_Mutationrs531685698c.326N>Ap.Arg109Glnp.R109QQ96C11protein_codingtolerated(0.62)benign(0.045)TCGA-DM-A0XD-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
FGGYSNVMissense_Mutationc.940N>Tp.Gly314Trpp.G314WQ96C11protein_codingdeleterious(0)probably_damaging(1)TCGA-F4-6808-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
FGGYSNVMissense_Mutationc.449T>Gp.Leu150Argp.L150RQ96C11protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AH-6643-01Colorectumrectum adenocarcinomaMale<65III/IVChemotherapyoxaliplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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