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Gene: FGFBP2 |
Gene summary for FGFBP2 |
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Gene information | Species | Human | Gene symbol | FGFBP2 | Gene ID | 83888 |
Gene name | fibroblast growth factor binding protein 2 | |
Gene Alias | HBP17RP | |
Cytomap | 4p15.32 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BYJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83888 | FGFBP2 | LZE2T | Human | Esophagus | ESCC | 7.52e-18 | 2.85e+00 | 0.082 |
83888 | FGFBP2 | LZE7T | Human | Esophagus | ESCC | 6.28e-20 | 2.42e+00 | 0.0667 |
83888 | FGFBP2 | LZE22T | Human | Esophagus | ESCC | 8.47e-11 | 1.72e+00 | 0.068 |
83888 | FGFBP2 | P2T-E | Human | Esophagus | ESCC | 9.44e-07 | 2.19e-01 | 0.1177 |
83888 | FGFBP2 | P9T-E | Human | Esophagus | ESCC | 4.83e-89 | 3.32e+00 | 0.1131 |
83888 | FGFBP2 | P12T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.35e-01 | 0.1122 |
83888 | FGFBP2 | P16T-E | Human | Esophagus | ESCC | 7.31e-14 | 3.57e-01 | 0.1153 |
83888 | FGFBP2 | P30T-E | Human | Esophagus | ESCC | 1.40e-60 | 5.46e+00 | 0.137 |
83888 | FGFBP2 | P31T-E | Human | Esophagus | ESCC | 4.16e-22 | 1.02e+00 | 0.1251 |
83888 | FGFBP2 | P32T-E | Human | Esophagus | ESCC | 2.13e-27 | 1.28e+00 | 0.1666 |
83888 | FGFBP2 | P39T-E | Human | Esophagus | ESCC | 1.78e-03 | 2.31e-01 | 0.0894 |
83888 | FGFBP2 | P48T-E | Human | Esophagus | ESCC | 4.17e-05 | 3.80e-01 | 0.0959 |
83888 | FGFBP2 | P56T-E | Human | Esophagus | ESCC | 3.89e-06 | 1.29e+00 | 0.1613 |
83888 | FGFBP2 | P76T-E | Human | Esophagus | ESCC | 1.96e-05 | 2.39e-01 | 0.1207 |
83888 | FGFBP2 | P130T-E | Human | Esophagus | ESCC | 2.62e-77 | 2.69e+00 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGFBP2 | SNV | Missense_Mutation | c.64C>A | p.Pro22Thr | p.P22T | Q9BYJ0 | protein_coding | tolerated(0.65) | possibly_damaging(0.604) | TCGA-E2-A14Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
FGFBP2 | SNV | Missense_Mutation | novel | c.545C>G | p.Thr182Arg | p.T182R | Q9BYJ0 | protein_coding | tolerated(0.5) | probably_damaging(0.966) | TCGA-GM-A3NY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
FGFBP2 | SNV | Missense_Mutation | novel | c.659T>C | p.Phe220Ser | p.F220S | Q9BYJ0 | protein_coding | deleterious(0) | possibly_damaging(0.611) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FGFBP2 | SNV | Missense_Mutation | rs146871123 | c.643N>A | p.Ala215Thr | p.A215T | Q9BYJ0 | protein_coding | tolerated(0.13) | benign(0.031) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
FGFBP2 | SNV | Missense_Mutation | novel | c.196N>G | p.Thr66Ala | p.T66A | Q9BYJ0 | protein_coding | tolerated(0.08) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFBP2 | SNV | Missense_Mutation | rs146871123 | c.643G>A | p.Ala215Thr | p.A215T | Q9BYJ0 | protein_coding | tolerated(0.13) | benign(0.031) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFBP2 | SNV | Missense_Mutation | c.514N>A | p.Leu172Met | p.L172M | Q9BYJ0 | protein_coding | tolerated(0.08) | possibly_damaging(0.879) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FGFBP2 | SNV | Missense_Mutation | c.131N>T | p.Thr44Ile | p.T44I | Q9BYJ0 | protein_coding | tolerated(0.18) | benign(0.153) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FGFBP2 | SNV | Missense_Mutation | c.174G>T | p.Trp58Cys | p.W58C | Q9BYJ0 | protein_coding | deleterious(0) | benign(0) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FGFBP2 | SNV | Missense_Mutation | c.611N>T | p.Glu204Val | p.E204V | Q9BYJ0 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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