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Gene: FEM1C |
Gene summary for FEM1C |
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Gene information | Species | Human | Gene symbol | FEM1C | Gene ID | 56929 |
Gene name | fem-1 homolog C | |
Gene Alias | EUROIMAGE686608 | |
Cytomap | 5q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96JP0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56929 | FEM1C | LZE20T | Human | Esophagus | ESCC | 2.64e-02 | -2.37e-02 | 0.0662 |
56929 | FEM1C | LZE24T | Human | Esophagus | ESCC | 6.65e-07 | 1.99e-01 | 0.0596 |
56929 | FEM1C | P1T-E | Human | Esophagus | ESCC | 2.91e-04 | 1.70e-01 | 0.0875 |
56929 | FEM1C | P2T-E | Human | Esophagus | ESCC | 8.58e-11 | 1.82e-01 | 0.1177 |
56929 | FEM1C | P4T-E | Human | Esophagus | ESCC | 1.12e-09 | 1.24e-01 | 0.1323 |
56929 | FEM1C | P5T-E | Human | Esophagus | ESCC | 4.67e-10 | 2.28e-01 | 0.1327 |
56929 | FEM1C | P8T-E | Human | Esophagus | ESCC | 4.97e-17 | 1.74e-01 | 0.0889 |
56929 | FEM1C | P9T-E | Human | Esophagus | ESCC | 1.28e-14 | 1.47e-01 | 0.1131 |
56929 | FEM1C | P10T-E | Human | Esophagus | ESCC | 1.77e-06 | 2.04e-02 | 0.116 |
56929 | FEM1C | P11T-E | Human | Esophagus | ESCC | 4.70e-03 | 2.46e-01 | 0.1426 |
56929 | FEM1C | P12T-E | Human | Esophagus | ESCC | 4.23e-11 | 2.79e-01 | 0.1122 |
56929 | FEM1C | P15T-E | Human | Esophagus | ESCC | 1.36e-18 | 4.23e-01 | 0.1149 |
56929 | FEM1C | P16T-E | Human | Esophagus | ESCC | 3.23e-03 | -5.42e-02 | 0.1153 |
56929 | FEM1C | P19T-E | Human | Esophagus | ESCC | 3.13e-03 | 2.02e-01 | 0.1662 |
56929 | FEM1C | P20T-E | Human | Esophagus | ESCC | 9.02e-11 | 1.59e-01 | 0.1124 |
56929 | FEM1C | P21T-E | Human | Esophagus | ESCC | 3.51e-09 | 6.64e-02 | 0.1617 |
56929 | FEM1C | P23T-E | Human | Esophagus | ESCC | 1.51e-15 | 2.39e-01 | 0.108 |
56929 | FEM1C | P24T-E | Human | Esophagus | ESCC | 3.29e-08 | 4.23e-02 | 0.1287 |
56929 | FEM1C | P26T-E | Human | Esophagus | ESCC | 2.00e-13 | 2.46e-01 | 0.1276 |
56929 | FEM1C | P27T-E | Human | Esophagus | ESCC | 1.18e-12 | 1.48e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FEM1C | SNV | Missense_Mutation | c.1492G>T | p.Gly498Trp | p.G498W | Q96JP0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FEM1C | insertion | In_Frame_Ins | novel | c.1505_1506insATTGGGAAACCAATG | p.Val502_Cys503insLeuGlyAsnGlnCys | p.V502_C503insLGNQC | Q96JP0 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FEM1C | SNV | Missense_Mutation | novel | c.518C>T | p.Ala173Val | p.A173V | Q96JP0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FEM1C | SNV | Missense_Mutation | novel | c.1621N>T | p.Pro541Ser | p.P541S | Q96JP0 | protein_coding | tolerated(0.11) | possibly_damaging(0.675) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FEM1C | SNV | Missense_Mutation | novel | c.376N>A | p.Asp126Asn | p.D126N | Q96JP0 | protein_coding | deleterious(0.02) | benign(0.058) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
FEM1C | SNV | Missense_Mutation | novel | c.1603G>C | p.Ala535Pro | p.A535P | Q96JP0 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FEM1C | SNV | Missense_Mutation | novel | c.421N>A | p.Asp141Asn | p.D141N | Q96JP0 | protein_coding | tolerated(0.17) | benign(0.385) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FEM1C | SNV | Missense_Mutation | c.1401N>C | p.Gln467His | p.Q467H | Q96JP0 | protein_coding | tolerated(0.08) | benign(0.038) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
FEM1C | deletion | Frame_Shift_Del | c.778delN | p.Arg260GlufsTer7 | p.R260Efs*7 | Q96JP0 | protein_coding | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |||
FEM1C | SNV | Missense_Mutation | novel | c.1814T>C | p.Ile605Thr | p.I605T | Q96JP0 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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