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Gene: FCMR |
Gene summary for FCMR |
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Gene information | Species | Human | Gene symbol | FCMR | Gene ID | 9214 |
Gene name | Fc fragment of IgM receptor | |
Gene Alias | FAIM3 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | O60667 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9214 | FCMR | LZE4T | Human | Esophagus | ESCC | 2.18e-02 | 1.26e-01 | 0.0811 |
9214 | FCMR | LZE7T | Human | Esophagus | ESCC | 1.83e-02 | 3.09e-01 | 0.0667 |
9214 | FCMR | LZE22D1 | Human | Esophagus | HGIN | 2.32e-03 | 3.18e-01 | 0.0595 |
9214 | FCMR | LZE24T | Human | Esophagus | ESCC | 2.86e-03 | 1.59e-01 | 0.0596 |
9214 | FCMR | LZE6T | Human | Esophagus | ESCC | 1.66e-03 | 2.55e-01 | 0.0845 |
9214 | FCMR | P2T-E | Human | Esophagus | ESCC | 2.85e-02 | 3.77e-02 | 0.1177 |
9214 | FCMR | P19T-E | Human | Esophagus | ESCC | 5.17e-03 | 2.88e-01 | 0.1662 |
9214 | FCMR | P21T-E | Human | Esophagus | ESCC | 1.85e-33 | 5.95e-01 | 0.1617 |
9214 | FCMR | P22T-E | Human | Esophagus | ESCC | 2.13e-02 | 3.74e-02 | 0.1236 |
9214 | FCMR | P23T-E | Human | Esophagus | ESCC | 7.67e-05 | 1.60e-01 | 0.108 |
9214 | FCMR | P24T-E | Human | Esophagus | ESCC | 2.50e-08 | 2.10e-01 | 0.1287 |
9214 | FCMR | P32T-E | Human | Esophagus | ESCC | 1.00e-04 | 8.94e-02 | 0.1666 |
9214 | FCMR | P37T-E | Human | Esophagus | ESCC | 2.47e-07 | 1.83e-01 | 0.1371 |
9214 | FCMR | P42T-E | Human | Esophagus | ESCC | 1.32e-02 | 1.52e-01 | 0.1175 |
9214 | FCMR | P57T-E | Human | Esophagus | ESCC | 1.10e-05 | 1.20e-01 | 0.0926 |
9214 | FCMR | P61T-E | Human | Esophagus | ESCC | 1.30e-03 | 1.69e-01 | 0.099 |
9214 | FCMR | P74T-E | Human | Esophagus | ESCC | 9.10e-06 | 1.93e-01 | 0.1479 |
9214 | FCMR | P75T-E | Human | Esophagus | ESCC | 5.63e-05 | 9.62e-02 | 0.1125 |
9214 | FCMR | P76T-E | Human | Esophagus | ESCC | 1.53e-05 | 1.50e-01 | 0.1207 |
9214 | FCMR | P79T-E | Human | Esophagus | ESCC | 4.84e-05 | 6.69e-02 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FCMR | SNV | Missense_Mutation | c.211G>C | p.Glu71Gln | p.E71Q | O60667 | protein_coding | deleterious(0.03) | possibly_damaging(0.796) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FCMR | SNV | Missense_Mutation | novel | c.202N>C | p.Ile68Leu | p.I68L | O60667 | protein_coding | deleterious(0.05) | benign(0.088) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
FCMR | SNV | Missense_Mutation | novel | c.725N>A | p.Gly242Asp | p.G242D | O60667 | protein_coding | tolerated(0.11) | benign(0.075) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
FCMR | insertion | Frame_Shift_Ins | novel | c.827_828insCACCTCTATGCAGTGGAGGTGC | p.Glu277ThrfsTer8 | p.E277Tfs*8 | O60667 | protein_coding | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
FCMR | insertion | Frame_Shift_Ins | novel | c.420_421insA | p.Trp141MetfsTer59 | p.W141Mfs*59 | O60667 | protein_coding | TCGA-B6-A0RO-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
FCMR | SNV | Missense_Mutation | c.973N>A | p.Ala325Thr | p.A325T | O60667 | protein_coding | tolerated(0.12) | benign(0.039) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FCMR | SNV | Missense_Mutation | novel | c.1052A>G | p.Glu351Gly | p.E351G | O60667 | protein_coding | deleterious(0.03) | benign(0.049) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FCMR | SNV | Missense_Mutation | c.467N>T | p.Ser156Phe | p.S156F | O60667 | protein_coding | deleterious(0) | possibly_damaging(0.687) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FCMR | SNV | Missense_Mutation | c.161N>A | p.Gly54Glu | p.G54E | O60667 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FCMR | SNV | Missense_Mutation | c.157N>A | p.Ala53Thr | p.A53T | O60667 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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