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Gene: FBXO8 |
Gene summary for FBXO8 |
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Gene information | Species | Human | Gene symbol | FBXO8 | Gene ID | 26269 |
Gene name | F-box protein 8 | |
Gene Alias | DC10 | |
Cytomap | 4q34.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A0S2Z5D1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26269 | FBXO8 | LZE4T | Human | Esophagus | ESCC | 4.93e-05 | 1.78e-01 | 0.0811 |
26269 | FBXO8 | LZE5T | Human | Esophagus | ESCC | 1.20e-04 | 3.61e-01 | 0.0514 |
26269 | FBXO8 | LZE20T | Human | Esophagus | ESCC | 8.89e-04 | 1.21e-01 | 0.0662 |
26269 | FBXO8 | LZE24T | Human | Esophagus | ESCC | 9.59e-11 | 2.94e-01 | 0.0596 |
26269 | FBXO8 | P1T-E | Human | Esophagus | ESCC | 1.53e-04 | 1.68e-01 | 0.0875 |
26269 | FBXO8 | P2T-E | Human | Esophagus | ESCC | 3.88e-24 | 2.62e-01 | 0.1177 |
26269 | FBXO8 | P4T-E | Human | Esophagus | ESCC | 6.82e-10 | 1.55e-01 | 0.1323 |
26269 | FBXO8 | P5T-E | Human | Esophagus | ESCC | 2.48e-05 | 9.83e-02 | 0.1327 |
26269 | FBXO8 | P8T-E | Human | Esophagus | ESCC | 8.10e-17 | 2.97e-01 | 0.0889 |
26269 | FBXO8 | P9T-E | Human | Esophagus | ESCC | 9.30e-07 | 1.21e-01 | 0.1131 |
26269 | FBXO8 | P10T-E | Human | Esophagus | ESCC | 1.18e-08 | 1.14e-01 | 0.116 |
26269 | FBXO8 | P11T-E | Human | Esophagus | ESCC | 5.33e-14 | 3.99e-01 | 0.1426 |
26269 | FBXO8 | P12T-E | Human | Esophagus | ESCC | 7.91e-27 | 4.49e-01 | 0.1122 |
26269 | FBXO8 | P15T-E | Human | Esophagus | ESCC | 1.76e-12 | 1.92e-01 | 0.1149 |
26269 | FBXO8 | P16T-E | Human | Esophagus | ESCC | 5.07e-17 | 2.45e-01 | 0.1153 |
26269 | FBXO8 | P17T-E | Human | Esophagus | ESCC | 5.35e-03 | 1.99e-01 | 0.1278 |
26269 | FBXO8 | P19T-E | Human | Esophagus | ESCC | 1.80e-02 | 1.96e-01 | 0.1662 |
26269 | FBXO8 | P20T-E | Human | Esophagus | ESCC | 1.96e-12 | 1.90e-01 | 0.1124 |
26269 | FBXO8 | P21T-E | Human | Esophagus | ESCC | 1.66e-08 | 2.25e-01 | 0.1617 |
26269 | FBXO8 | P22T-E | Human | Esophagus | ESCC | 9.71e-08 | 2.06e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:00465788 | Oral cavity | OSCC | regulation of Ras protein signal transduction | 90/7305 | 189/18723 | 9.58e-03 | 3.40e-02 | 90 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO8 | SNV | Missense_Mutation | novel | c.154N>A | p.Asp52Asn | p.D52N | Q9NRD0 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.487) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
FBXO8 | SNV | Missense_Mutation | novel | c.433N>C | p.Thr145Pro | p.T145P | Q9NRD0 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO8 | SNV | Missense_Mutation | c.182A>C | p.Lys61Thr | p.K61T | Q9NRD0 | protein_coding | tolerated(0.09) | benign(0.012) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
FBXO8 | deletion | Frame_Shift_Del | novel | c.514_515delAA | p.Lys172ValfsTer18 | p.K172Vfs*18 | Q9NRD0 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FBXO8 | insertion | Frame_Shift_Ins | novel | c.893_894insA | p.Asn298LysfsTer3 | p.N298Kfs*3 | Q9NRD0 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FBXO8 | SNV | Missense_Mutation | rs747265345 | c.881G>A | p.Arg294His | p.R294H | Q9NRD0 | protein_coding | tolerated(0.11) | benign(0.067) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FBXO8 | SNV | Missense_Mutation | novel | c.898N>C | p.Ser300Arg | p.S300R | Q9NRD0 | protein_coding | tolerated(0.08) | probably_damaging(0.915) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO8 | SNV | Missense_Mutation | rs138114332 | c.298N>A | p.Asp100Asn | p.D100N | Q9NRD0 | protein_coding | tolerated(0.17) | benign(0.018) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO8 | SNV | Missense_Mutation | c.929N>G | p.Asn310Ser | p.N310S | Q9NRD0 | protein_coding | deleterious(0.01) | probably_damaging(0.927) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBXO8 | SNV | Missense_Mutation | c.877N>T | p.Arg293Cys | p.R293C | Q9NRD0 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-AP-A0LL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxifen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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