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Gene: FBXO42 |
Gene summary for FBXO42 |
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Gene information | Species | Human | Gene symbol | FBXO42 | Gene ID | 54455 |
Gene name | F-box protein 42 | |
Gene Alias | Fbx42 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024QZB0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54455 | FBXO42 | CCI_1 | Human | Cervix | CC | 1.44e-09 | 1.01e+00 | 0.528 |
54455 | FBXO42 | CCI_2 | Human | Cervix | CC | 7.14e-07 | 9.28e-01 | 0.5249 |
54455 | FBXO42 | CCI_3 | Human | Cervix | CC | 5.48e-10 | 7.11e-01 | 0.516 |
54455 | FBXO42 | AEH-subject1 | Human | Endometrium | AEH | 4.73e-08 | 2.59e-01 | -0.3059 |
54455 | FBXO42 | AEH-subject2 | Human | Endometrium | AEH | 1.35e-05 | 2.92e-01 | -0.2525 |
54455 | FBXO42 | AEH-subject3 | Human | Endometrium | AEH | 6.45e-04 | 1.96e-01 | -0.2576 |
54455 | FBXO42 | AEH-subject4 | Human | Endometrium | AEH | 2.06e-08 | 4.34e-01 | -0.2657 |
54455 | FBXO42 | AEH-subject5 | Human | Endometrium | AEH | 1.12e-10 | 3.72e-01 | -0.2953 |
54455 | FBXO42 | EEC-subject1 | Human | Endometrium | EEC | 2.71e-07 | 3.15e-01 | -0.2682 |
54455 | FBXO42 | EEC-subject2 | Human | Endometrium | EEC | 1.31e-02 | 2.71e-01 | -0.2607 |
54455 | FBXO42 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.05e-04 | -3.97e-02 | -0.1869 |
54455 | FBXO42 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.37e-05 | -3.75e-02 | -0.1875 |
54455 | FBXO42 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.46e-06 | -2.04e-02 | -0.1883 |
54455 | FBXO42 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.48e-05 | -5.86e-03 | -0.1934 |
54455 | FBXO42 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.45e-08 | 2.28e-03 | -0.1917 |
54455 | FBXO42 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.43e-06 | -4.53e-02 | -0.1916 |
54455 | FBXO42 | LZE4T | Human | Esophagus | ESCC | 2.05e-05 | 1.51e-01 | 0.0811 |
54455 | FBXO42 | LZE7T | Human | Esophagus | ESCC | 5.58e-07 | 2.59e-01 | 0.0667 |
54455 | FBXO42 | LZE8T | Human | Esophagus | ESCC | 2.41e-02 | 1.37e-01 | 0.067 |
54455 | FBXO42 | LZE20T | Human | Esophagus | ESCC | 3.61e-03 | 1.67e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO42 | SNV | Missense_Mutation | c.1216G>C | p.Gly406Arg | p.G406R | Q6P3S6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
FBXO42 | SNV | Missense_Mutation | novel | c.1867N>T | p.His623Tyr | p.H623Y | Q6P3S6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.61) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FBXO42 | insertion | Frame_Shift_Ins | novel | c.1424_1425insATTTTCCAGTGTGT | p.Asp475GlufsTer7 | p.D475Efs*7 | Q6P3S6 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
FBXO42 | insertion | Frame_Shift_Ins | novel | c.1422_1423insCCCTTTCCTTTTCTGTGGCTTTTAATTTG | p.Asp475ProfsTer12 | p.D475Pfs*12 | Q6P3S6 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
FBXO42 | insertion | Frame_Shift_Ins | novel | c.1213_1214insTGAGACACCCTCCTGAACAGACAAATGGTGTGCAT | p.Asn405MetfsTer19 | p.N405Mfs*19 | Q6P3S6 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
FBXO42 | insertion | Frame_Shift_Ins | novel | c.1867_1868insGAAG | p.His623ArgfsTer31 | p.H623Rfs*31 | Q6P3S6 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
FBXO42 | insertion | Frame_Shift_Ins | novel | c.1280_1281insTATGAGACACCCTCCTGAACAGACAAATGGTGTGCATACCC | p.Leu428MetfsTer63 | p.L428Mfs*63 | Q6P3S6 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FBXO42 | deletion | Frame_Shift_Del | novel | c.1345delG | p.Ala449GlnfsTer28 | p.A449Qfs*28 | Q6P3S6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FBXO42 | SNV | Missense_Mutation | rs760530903 | c.1715C>T | p.Ser572Leu | p.S572L | Q6P3S6 | protein_coding | deleterious_low_confidence(0.03) | benign(0.025) | TCGA-C5-A7X8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
FBXO42 | SNV | Missense_Mutation | novel | c.1393C>G | p.Pro465Ala | p.P465A | Q6P3S6 | protein_coding | deleterious_low_confidence(0) | benign(0.066) | TCGA-C5-A7X8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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