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Gene: FBXL20 |
Gene summary for FBXL20 |
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Gene information | Species | Human | Gene symbol | FBXL20 | Gene ID | 84961 |
Gene name | F-box and leucine rich repeat protein 20 | |
Gene Alias | Fbl2 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q96IG2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84961 | FBXL20 | GSM4909291 | Human | Breast | IDC | 3.49e-23 | 6.59e-01 | 0.1753 |
84961 | FBXL20 | GSM4909293 | Human | Breast | IDC | 1.22e-22 | 5.20e-01 | 0.1581 |
84961 | FBXL20 | DCIS2 | Human | Breast | DCIS | 3.05e-19 | 8.92e-02 | 0.0085 |
84961 | FBXL20 | CCI_2 | Human | Cervix | CC | 2.79e-09 | 9.33e-01 | 0.5249 |
84961 | FBXL20 | CCI_3 | Human | Cervix | CC | 1.52e-13 | 7.54e-01 | 0.516 |
84961 | FBXL20 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.28e-16 | 6.80e-01 | -0.1954 |
84961 | FBXL20 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.62e-03 | 5.14e-01 | 0.281 |
84961 | FBXL20 | A015-C-203 | Human | Colorectum | FAP | 1.49e-22 | -2.91e-01 | -0.1294 |
84961 | FBXL20 | A015-C-204 | Human | Colorectum | FAP | 7.84e-03 | -2.87e-01 | -0.0228 |
84961 | FBXL20 | A014-C-040 | Human | Colorectum | FAP | 6.80e-05 | -5.26e-01 | -0.1184 |
84961 | FBXL20 | A002-C-201 | Human | Colorectum | FAP | 1.08e-10 | -2.80e-01 | 0.0324 |
84961 | FBXL20 | A001-C-119 | Human | Colorectum | FAP | 1.06e-03 | 3.43e-02 | -0.1557 |
84961 | FBXL20 | A001-C-108 | Human | Colorectum | FAP | 7.87e-10 | -1.46e-01 | -0.0272 |
84961 | FBXL20 | A002-C-205 | Human | Colorectum | FAP | 1.42e-17 | -2.83e-01 | -0.1236 |
84961 | FBXL20 | A001-C-104 | Human | Colorectum | FAP | 4.75e-02 | -1.27e-01 | 0.0184 |
84961 | FBXL20 | A015-C-006 | Human | Colorectum | FAP | 2.52e-15 | -4.95e-01 | -0.0994 |
84961 | FBXL20 | A015-C-106 | Human | Colorectum | FAP | 1.97e-09 | -1.71e-01 | -0.0511 |
84961 | FBXL20 | A002-C-114 | Human | Colorectum | FAP | 1.04e-15 | -3.84e-01 | -0.1561 |
84961 | FBXL20 | A015-C-104 | Human | Colorectum | FAP | 1.91e-24 | -3.39e-01 | -0.1899 |
84961 | FBXL20 | A001-C-014 | Human | Colorectum | FAP | 1.84e-11 | -3.11e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:004217614 | Breast | IDC | regulation of protein catabolic process | 63/1434 | 391/18723 | 1.32e-08 | 9.61e-07 | 63 |
GO:004316114 | Breast | IDC | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1434 | 412/18723 | 9.55e-06 | 2.68e-04 | 57 |
GO:001049824 | Breast | DCIS | proteasomal protein catabolic process | 75/1390 | 490/18723 | 1.44e-09 | 1.40e-07 | 75 |
GO:004217624 | Breast | DCIS | regulation of protein catabolic process | 62/1390 | 391/18723 | 9.98e-09 | 7.53e-07 | 62 |
GO:004316124 | Breast | DCIS | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1390 | 412/18723 | 3.76e-06 | 1.16e-04 | 57 |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00171574 | Cervix | CC | regulation of exocytosis | 39/2311 | 202/18723 | 2.90e-03 | 1.93e-02 | 39 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00421762 | Colorectum | MSS | regulation of protein catabolic process | 145/3467 | 391/18723 | 2.03e-18 | 1.17e-15 | 145 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXL20 | SNV | Missense_Mutation | c.72N>G | p.Ile24Met | p.I24M | Q96IG2 | protein_coding | deleterious(0) | possibly_damaging(0.695) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
FBXL20 | SNV | Missense_Mutation | novel | c.1000C>G | p.His334Asp | p.H334D | Q96IG2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FBXL20 | SNV | Missense_Mutation | c.281N>A | p.Arg94Gln | p.R94Q | Q96IG2 | protein_coding | deleterious(0.01) | possibly_damaging(0.769) | TCGA-VS-A8Q8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
FBXL20 | SNV | Missense_Mutation | novel | c.754N>A | p.Leu252Ile | p.L252I | Q96IG2 | protein_coding | tolerated(0.11) | possibly_damaging(0.536) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FBXL20 | SNV | Missense_Mutation | novel | c.1163A>C | p.Asp388Ala | p.D388A | Q96IG2 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FBXL20 | SNV | Missense_Mutation | c.1054N>A | p.Ala352Thr | p.A352T | Q96IG2 | protein_coding | tolerated(0.09) | possibly_damaging(0.734) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
FBXL20 | SNV | Missense_Mutation | c.1016C>T | p.Thr339Ile | p.T339I | Q96IG2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FBXL20 | SNV | Missense_Mutation | novel | c.479C>A | p.Ser160Tyr | p.S160Y | Q96IG2 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FBXL20 | SNV | Missense_Mutation | c.1201A>T | p.Arg401Trp | p.R401W | Q96IG2 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
FBXL20 | SNV | Missense_Mutation | c.281G>A | p.Arg94Gln | p.R94Q | Q96IG2 | protein_coding | deleterious(0.01) | possibly_damaging(0.769) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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