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Gene: FBRSL1 |
Gene summary for FBRSL1 |
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Gene information | Species | Human | Gene symbol | FBRSL1 | Gene ID | 57666 |
Gene name | fibrosin like 1 | |
Gene Alias | FBRSL1 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9HCM7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57666 | FBRSL1 | LZE2T | Human | Esophagus | ESCC | 5.16e-04 | 3.00e-01 | 0.082 |
57666 | FBRSL1 | LZE24T | Human | Esophagus | ESCC | 7.12e-10 | 1.02e-01 | 0.0596 |
57666 | FBRSL1 | P1T-E | Human | Esophagus | ESCC | 6.88e-09 | 2.33e-01 | 0.0875 |
57666 | FBRSL1 | P2T-E | Human | Esophagus | ESCC | 1.56e-17 | 3.22e-01 | 0.1177 |
57666 | FBRSL1 | P4T-E | Human | Esophagus | ESCC | 3.69e-13 | 2.83e-01 | 0.1323 |
57666 | FBRSL1 | P5T-E | Human | Esophagus | ESCC | 8.11e-14 | 2.05e-01 | 0.1327 |
57666 | FBRSL1 | P8T-E | Human | Esophagus | ESCC | 1.33e-17 | 1.95e-01 | 0.0889 |
57666 | FBRSL1 | P9T-E | Human | Esophagus | ESCC | 1.61e-09 | 1.59e-01 | 0.1131 |
57666 | FBRSL1 | P10T-E | Human | Esophagus | ESCC | 2.66e-11 | 2.67e-01 | 0.116 |
57666 | FBRSL1 | P11T-E | Human | Esophagus | ESCC | 2.75e-03 | 6.90e-02 | 0.1426 |
57666 | FBRSL1 | P12T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.28e-01 | 0.1122 |
57666 | FBRSL1 | P15T-E | Human | Esophagus | ESCC | 1.85e-14 | 2.69e-01 | 0.1149 |
57666 | FBRSL1 | P16T-E | Human | Esophagus | ESCC | 1.50e-05 | 7.13e-02 | 0.1153 |
57666 | FBRSL1 | P17T-E | Human | Esophagus | ESCC | 2.90e-03 | 1.12e-01 | 0.1278 |
57666 | FBRSL1 | P20T-E | Human | Esophagus | ESCC | 9.67e-06 | 1.34e-01 | 0.1124 |
57666 | FBRSL1 | P21T-E | Human | Esophagus | ESCC | 1.41e-19 | 1.71e-01 | 0.1617 |
57666 | FBRSL1 | P22T-E | Human | Esophagus | ESCC | 6.48e-16 | 1.23e-01 | 0.1236 |
57666 | FBRSL1 | P23T-E | Human | Esophagus | ESCC | 9.21e-09 | 1.73e-01 | 0.108 |
57666 | FBRSL1 | P24T-E | Human | Esophagus | ESCC | 4.47e-04 | 3.33e-02 | 0.1287 |
57666 | FBRSL1 | P26T-E | Human | Esophagus | ESCC | 6.35e-10 | 9.30e-02 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBRSL1 | SNV | Missense_Mutation | c.1981N>A | p.Ser661Thr | p.S661T | Q9HCM7 | protein_coding | tolerated(0.89) | benign(0.022) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
FBRSL1 | SNV | Missense_Mutation | novel | c.1314N>T | p.Glu438Asp | p.E438D | Q9HCM7 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-E9-A245-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
FBRSL1 | SNV | Missense_Mutation | novel | c.1976N>T | p.Pro659Leu | p.P659L | Q9HCM7 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-EW-A6SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | aromatase | SD |
FBRSL1 | SNV | Missense_Mutation | novel | c.1481N>T | p.Ser494Ile | p.S494I | Q9HCM7 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
FBRSL1 | SNV | Missense_Mutation | c.1763N>T | p.Pro588Leu | p.P588L | Q9HCM7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FBRSL1 | SNV | Missense_Mutation | c.1435N>C | p.Asp479His | p.D479H | Q9HCM7 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FBRSL1 | SNV | Missense_Mutation | c.2243N>T | p.Pro748Leu | p.P748L | Q9HCM7 | protein_coding | tolerated(0.06) | probably_damaging(0.925) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBRSL1 | SNV | Missense_Mutation | c.1684C>T | p.Arg562Cys | p.R562C | Q9HCM7 | protein_coding | tolerated(0.08) | benign(0) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
FBRSL1 | SNV | Missense_Mutation | c.404N>A | p.Arg135Gln | p.R135Q | Q9HCM7 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBRSL1 | deletion | Frame_Shift_Del | c.1382delN | p.Phe463SerfsTer33 | p.F463Sfs*33 | Q9HCM7 | protein_coding | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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