Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FBLN5

Gene summary for FBLN5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FBLN5

Gene ID

10516

Gene namefibulin 5
Gene AliasADCL2
Cytomap14q32.12
Gene Typeprotein-coding
GO ID

GO:0000302

UniProtAcc

A0A024R6G3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10516FBLN5C08HumanOral cavityOSCC4.75e-021.16e-010.1919
10516FBLN5C09HumanOral cavityOSCC6.73e-073.88e-010.1431
10516FBLN5NEOLP-1HumanOral cavityNEOLP1.88e-021.59e-01-0.0194
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000697920Oral cavityOSCCresponse to oxidative stress273/7305446/187238.35e-221.65e-19273
GO:006219720Oral cavityOSCCcellular response to chemical stress204/7305337/187236.89e-165.19e-14204
GO:000030220Oral cavityOSCCresponse to reactive oxygen species143/7305222/187231.32e-147.88e-13143
GO:001604917Oral cavityOSCCcell growth268/7305482/187236.55e-143.51e-12268
GO:003459920Oral cavityOSCCcellular response to oxidative stress173/7305288/187232.90e-131.43e-11173
GO:000155816Oral cavityOSCCregulation of cell growth228/7305414/187231.74e-116.09e-10228
GO:003461419Oral cavityOSCCcellular response to reactive oxygen species96/7305155/187235.98e-091.27e-0796
GO:003158917Oral cavityOSCCcell-substrate adhesion193/7305363/187232.48e-084.82e-07193
GO:200037716Oral cavityOSCCregulation of reactive oxygen species metabolic process92/7305157/187234.96e-077.27e-0692
GO:000716016Oral cavityOSCCcell-matrix adhesion125/7305233/187233.76e-064.45e-05125
GO:000963618Oral cavityOSCCresponse to toxic substance137/7305262/187237.94e-068.52e-05137
GO:007259316Oral cavityOSCCreactive oxygen species metabolic process122/7305239/187239.73e-057.34e-04122
GO:00301983Oral cavityOSCCextracellular matrix organization146/7305301/187234.67e-042.77e-03146
GO:0085029Oral cavityOSCCextracellular matrix assembly29/730545/187234.85e-042.86e-0329
GO:00452293Oral cavityOSCCexternal encapsulating structure organization147/7305304/187235.30e-043.08e-03147
GO:00430623Oral cavityOSCCextracellular structure organization146/7305302/187235.59e-043.23e-03146
GO:199074818Oral cavityOSCCcellular detoxification63/7305116/187235.80e-043.31e-0363
GO:009886918Oral cavityOSCCcellular oxidant detoxification55/7305101/187231.16e-035.89e-0355
GO:009723718Oral cavityOSCCcellular response to toxic substance65/7305124/187231.63e-037.74e-0365
GO:190040718Oral cavityOSCCregulation of cellular response to oxidative stress47/730589/187235.62e-032.17e-0247
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FBLN5SNVMissense_Mutationnovelc.743T>Cp.Met248Thrp.M248TQ9UBX5protein_codingdeleterious(0.03)benign(0.077)TCGA-A7-A13H-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyanastrozolePD
FBLN5SNVMissense_Mutationrs140452924c.1093N>Gp.Ile365Valp.I365VQ9UBX5protein_codingtolerated(0.21)possibly_damaging(0.785)TCGA-EW-A1P3-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
FBLN5SNVMissense_Mutationrs760345539c.230N>Ap.Arg77Glnp.R77QQ9UBX5protein_codingtolerated(0.59)possibly_damaging(0.705)TCGA-PE-A5DE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
FBLN5insertionFrame_Shift_Insnovelc.1146_1147insCCTCTGTGGTCACGCTGCCTCCTCTTCCTCCTCTGTGTGTp.Ile383ProfsTer19p.I383Pfs*19Q9UBX5protein_codingTCGA-A8-A07R-01Breastbreast invasive carcinomaFemale>=65III/IVAncillaryzoledronicSD
FBLN5insertionNonsense_Mutationnovelc.1066_1067insAAGCCAGGAGTCTGAAATCAGTTTCACTGAGCTGAAATCCAp.Val356GlufsTer12p.V356Efs*12Q9UBX5protein_codingTCGA-AO-A0JF-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydoxorubicinSD
FBLN5SNVMissense_Mutationnovelc.8N>Ap.Gly3Glup.G3EQ9UBX5protein_codingtolerated_low_confidence(0.15)probably_damaging(0.972)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
FBLN5SNVMissense_Mutationc.472G>Ap.Gly158Argp.G158RQ9UBX5protein_codingdeleterious(0)probably_damaging(1)TCGA-Q1-A6DT-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
FBLN5SNVMissense_Mutationc.368N>Gp.Asn123Serp.N123SQ9UBX5protein_codingtolerated(0.25)benign(0.026)TCGA-AZ-6598-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
FBLN5SNVMissense_Mutationc.566C>Ap.Ser189Tyrp.S189YQ9UBX5protein_codingtolerated(1)probably_damaging(0.995)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
FBLN5SNVMissense_Mutationnovelc.1061A>Gp.Asp354Glyp.D354GQ9UBX5protein_codingtolerated(0.05)possibly_damaging(0.677)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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