Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FASTKD2

Gene summary for FASTKD2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FASTKD2

Gene ID

22868

Gene nameFAST kinase domains 2
Gene AliasCOXPD44
Cytomap2q33.3
Gene Typeprotein-coding
GO ID

GO:0000027

UniProtAcc

A0A024R419


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
22868FASTKD2LZE4THumanEsophagusESCC1.01e-078.15e-020.0811
22868FASTKD2LZE5THumanEsophagusESCC6.72e-041.11e-010.0514
22868FASTKD2LZE7THumanEsophagusESCC5.01e-072.26e-010.0667
22868FASTKD2LZE24THumanEsophagusESCC9.77e-081.05e-010.0596
22868FASTKD2LZE21THumanEsophagusESCC1.51e-024.13e-020.0655
22868FASTKD2P1T-EHumanEsophagusESCC4.44e-072.07e-010.0875
22868FASTKD2P2T-EHumanEsophagusESCC5.49e-193.13e-010.1177
22868FASTKD2P4T-EHumanEsophagusESCC1.54e-265.36e-010.1323
22868FASTKD2P5T-EHumanEsophagusESCC4.45e-062.14e-020.1327
22868FASTKD2P8T-EHumanEsophagusESCC5.42e-191.84e-010.0889
22868FASTKD2P9T-EHumanEsophagusESCC4.45e-117.40e-020.1131
22868FASTKD2P10T-EHumanEsophagusESCC4.20e-112.34e-010.116
22868FASTKD2P11T-EHumanEsophagusESCC5.75e-063.37e-010.1426
22868FASTKD2P12T-EHumanEsophagusESCC2.78e-285.60e-010.1122
22868FASTKD2P15T-EHumanEsophagusESCC2.03e-265.61e-010.1149
22868FASTKD2P16T-EHumanEsophagusESCC1.36e-233.16e-010.1153
22868FASTKD2P17T-EHumanEsophagusESCC3.10e-082.18e-010.1278
22868FASTKD2P19T-EHumanEsophagusESCC6.12e-032.04e-010.1662
22868FASTKD2P20T-EHumanEsophagusESCC1.41e-152.92e-010.1124
22868FASTKD2P21T-EHumanEsophagusESCC6.02e-163.77e-010.1617
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0022613111EsophagusESCCribonucleoprotein complex biogenesis365/8552463/187231.74e-491.11e-45365
GO:0042254111EsophagusESCCribosome biogenesis252/8552299/187233.27e-441.04e-40252
GO:1903311110EsophagusESCCregulation of mRNA metabolic process210/8552288/187233.25e-215.56e-19210
GO:0006401110EsophagusESCCRNA catabolic process204/8552278/187233.39e-215.66e-19204
GO:014005313EsophagusESCCmitochondrial gene expression93/8552108/187231.96e-182.03e-1693
GO:0034655110EsophagusESCCnucleobase-containing compound catabolic process272/8552407/187232.92e-182.90e-16272
GO:0006402110EsophagusESCCmRNA catabolic process170/8552232/187238.70e-188.00e-16170
GO:0006417111EsophagusESCCregulation of translation304/8552468/187231.53e-171.33e-15304
GO:0071826111EsophagusESCCribonucleoprotein complex subunit organization166/8552227/187232.94e-172.42e-15166
GO:0022618111EsophagusESCCribonucleoprotein complex assembly159/8552220/187238.19e-165.71e-14159
GO:003254314EsophagusESCCmitochondrial translation68/855276/187231.02e-156.86e-1468
GO:004670018EsophagusESCCheterocycle catabolic process286/8552445/187231.12e-157.47e-14286
GO:0042273111EsophagusESCCribosomal large subunit biogenesis65/855272/187231.53e-159.82e-1465
GO:0045727111EsophagusESCCpositive regulation of translation107/8552136/187232.79e-151.68e-13107
GO:004427019EsophagusESCCcellular nitrogen compound catabolic process288/8552451/187233.03e-151.79e-13288
GO:0034250111EsophagusESCCpositive regulation of cellular amide metabolic process123/8552162/187233.32e-151.93e-13123
GO:001943918EsophagusESCCaromatic compound catabolic process295/8552467/187231.09e-145.98e-13295
GO:190136118EsophagusESCCorganic cyclic compound catabolic process307/8552495/187239.99e-144.80e-12307
GO:006101319EsophagusESCCregulation of mRNA catabolic process115/8552166/187235.90e-101.49e-08115
GO:004348719EsophagusESCCregulation of RNA stability117/8552170/187237.91e-101.94e-08117
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FASTKD2SNVMissense_Mutationc.2123N>Cp.Ser708Thrp.S708TQ9NYY8protein_codingdeleterious_low_confidence(0.01)benign(0.165)TCGA-A8-A075-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyepirubicinCR
FASTKD2SNVMissense_Mutationc.1171N>Cp.Asp391Hisp.D391HQ9NYY8protein_codingdeleterious(0.02)probably_damaging(0.923)TCGA-A8-A07W-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyexemestaneSD
FASTKD2SNVMissense_Mutationc.1391C>Tp.Ser464Phep.S464FQ9NYY8protein_codingdeleterious(0)probably_damaging(0.993)TCGA-A8-A093-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
FASTKD2SNVMissense_Mutationc.589N>Ap.Asp197Asnp.D197NQ9NYY8protein_codingtolerated(0.06)benign(0.011)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
FASTKD2SNVMissense_Mutationc.1279N>Ap.Glu427Lysp.E427KQ9NYY8protein_codingdeleterious(0.03)probably_damaging(0.999)TCGA-E9-A1NF-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinPD
FASTKD2SNVMissense_Mutationnovelc.123N>Ap.Met41Ilep.M41IQ9NYY8protein_codingtolerated(0.15)benign(0.009)TCGA-EW-A3E8-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyanastrozoleSD
FASTKD2insertionNonsense_Mutationnovelc.1544_1545insCATTTATTAGTGGTGTCACTCTGGGCAAGCGACTGCCCCTGAp.Pro515_Phe516insIleTyrTerTrpCysHisSerGlyGlnAlaThrAlaProAspp.P515_F516insIY*WCHSGQATAPDQ9NYY8protein_codingTCGA-A8-A07G-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
FASTKD2insertionFrame_Shift_Insnovelc.196_197insGTGACCTGGCTTCTTTGAAACTGGACp.Asn66SerfsTer39p.N66Sfs*39Q9NYY8protein_codingTCGA-AO-A0J3-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamideSD
FASTKD2SNVMissense_Mutationrs774329789c.1016G>Ap.Arg339Lysp.R339KQ9NYY8protein_codingtolerated(0.39)benign(0.003)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
FASTKD2SNVMissense_Mutationc.483N>Tp.Glu161Aspp.E161DQ9NYY8protein_codingtolerated(0.07)benign(0.024)TCGA-A6-5665-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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