![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FAM96A |
Gene summary for FAM96A |
![]() |
Gene information | Species | Human | Gene symbol | FAM96A | Gene ID | 84191 |
Gene name | cytosolic iron-sulfur assembly component 2A | |
Gene Alias | CIA2A | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | Q9H5X1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84191 | FAM96A | P1T-E | Human | Esophagus | ESCC | 2.09e-08 | 6.92e-01 | 0.0875 |
84191 | FAM96A | P2T-E | Human | Esophagus | ESCC | 2.48e-57 | 1.00e+00 | 0.1177 |
84191 | FAM96A | P4T-E | Human | Esophagus | ESCC | 3.73e-45 | 1.29e+00 | 0.1323 |
84191 | FAM96A | P5T-E | Human | Esophagus | ESCC | 1.02e-48 | 9.61e-01 | 0.1327 |
84191 | FAM96A | P8T-E | Human | Esophagus | ESCC | 1.94e-57 | 1.27e+00 | 0.0889 |
84191 | FAM96A | P9T-E | Human | Esophagus | ESCC | 3.00e-35 | 9.62e-01 | 0.1131 |
84191 | FAM96A | P10T-E | Human | Esophagus | ESCC | 6.47e-63 | 1.12e+00 | 0.116 |
84191 | FAM96A | P11T-E | Human | Esophagus | ESCC | 4.62e-17 | 8.47e-01 | 0.1426 |
84191 | FAM96A | P12T-E | Human | Esophagus | ESCC | 7.50e-54 | 9.40e-01 | 0.1122 |
84191 | FAM96A | P15T-E | Human | Esophagus | ESCC | 3.72e-50 | 1.13e+00 | 0.1149 |
84191 | FAM96A | P16T-E | Human | Esophagus | ESCC | 7.85e-72 | 1.32e+00 | 0.1153 |
84191 | FAM96A | P17T-E | Human | Esophagus | ESCC | 1.21e-07 | 4.63e-01 | 0.1278 |
84191 | FAM96A | P19T-E | Human | Esophagus | ESCC | 8.62e-07 | 1.33e+00 | 0.1662 |
84191 | FAM96A | P20T-E | Human | Esophagus | ESCC | 4.79e-32 | 8.23e-01 | 0.1124 |
84191 | FAM96A | P21T-E | Human | Esophagus | ESCC | 1.30e-47 | 1.01e+00 | 0.1617 |
84191 | FAM96A | P22T-E | Human | Esophagus | ESCC | 4.19e-61 | 1.11e+00 | 0.1236 |
84191 | FAM96A | P23T-E | Human | Esophagus | ESCC | 5.35e-50 | 1.37e+00 | 0.108 |
84191 | FAM96A | P24T-E | Human | Esophagus | ESCC | 1.24e-34 | 7.79e-01 | 0.1287 |
84191 | FAM96A | P26T-E | Human | Esophagus | ESCC | 4.98e-52 | 9.94e-01 | 0.1276 |
84191 | FAM96A | P27T-E | Human | Esophagus | ESCC | 8.84e-29 | 5.70e-01 | 0.1055 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM96A | SNV | Missense_Mutation | novel | c.87N>T | p.Gln29His | p.Q29H | Q9H5X1 | protein_coding | tolerated(0.06) | benign(0.28) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
FAM96A | SNV | Missense_Mutation | c.382N>C | p.Asp128His | p.D128H | Q9H5X1 | protein_coding | tolerated(0.08) | probably_damaging(0.996) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM96A | SNV | Missense_Mutation | c.103G>C | p.Glu35Gln | p.E35Q | Q9H5X1 | protein_coding | tolerated(0.08) | benign(0.425) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
FAM96A | SNV | Missense_Mutation | novel | c.65N>T | p.Ser22Phe | p.S22F | Q9H5X1 | protein_coding | tolerated(0.14) | benign(0) | TCGA-OL-A66L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM96A | SNV | Missense_Mutation | novel | c.58N>T | p.Gly20Cys | p.G20C | Q9H5X1 | protein_coding | deleterious(0) | benign(0.056) | TCGA-C5-A1M9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FAM96A | SNV | Missense_Mutation | c.356C>G | p.Ser119Cys | p.S119C | Q9H5X1 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM96A | SNV | Missense_Mutation | novel | c.425N>T | p.Ala142Val | p.A142V | Q9H5X1 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM96A | SNV | Missense_Mutation | c.64T>C | p.Ser22Pro | p.S22P | Q9H5X1 | protein_coding | tolerated(0.19) | benign(0.102) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
FAM96A | SNV | Missense_Mutation | novel | c.235G>A | p.Val79Ile | p.V79I | Q9H5X1 | protein_coding | tolerated(0.34) | benign(0.019) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
FAM96A | SNV | Missense_Mutation | c.158N>T | p.Pro53Leu | p.P53L | Q9H5X1 | protein_coding | deleterious(0) | benign(0.019) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |