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Gene: FAM89A |
Gene summary for FAM89A |
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Gene information | Species | Human | Gene symbol | FAM89A | Gene ID | 375061 |
Gene name | family with sequence similarity 89 member A | |
Gene Alias | C1orf153 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96GI7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375061 | FAM89A | LZE2T | Human | Esophagus | ESCC | 6.92e-04 | 2.89e-01 | 0.082 |
375061 | FAM89A | P2T-E | Human | Esophagus | ESCC | 1.75e-09 | 2.93e-02 | 0.1177 |
375061 | FAM89A | P4T-E | Human | Esophagus | ESCC | 3.65e-06 | 1.03e-01 | 0.1323 |
375061 | FAM89A | P5T-E | Human | Esophagus | ESCC | 1.47e-15 | 3.28e-01 | 0.1327 |
375061 | FAM89A | P8T-E | Human | Esophagus | ESCC | 3.64e-02 | -6.63e-02 | 0.0889 |
375061 | FAM89A | P9T-E | Human | Esophagus | ESCC | 8.05e-15 | 2.36e-01 | 0.1131 |
375061 | FAM89A | P10T-E | Human | Esophagus | ESCC | 7.99e-09 | 6.55e-02 | 0.116 |
375061 | FAM89A | P12T-E | Human | Esophagus | ESCC | 2.73e-04 | 1.05e-02 | 0.1122 |
375061 | FAM89A | P16T-E | Human | Esophagus | ESCC | 3.37e-02 | -3.93e-02 | 0.1153 |
375061 | FAM89A | P21T-E | Human | Esophagus | ESCC | 2.40e-09 | 3.36e-01 | 0.1617 |
375061 | FAM89A | P22T-E | Human | Esophagus | ESCC | 1.38e-13 | 6.76e-02 | 0.1236 |
375061 | FAM89A | P23T-E | Human | Esophagus | ESCC | 3.29e-04 | 1.02e-01 | 0.108 |
375061 | FAM89A | P24T-E | Human | Esophagus | ESCC | 5.91e-06 | -5.12e-02 | 0.1287 |
375061 | FAM89A | P26T-E | Human | Esophagus | ESCC | 5.58e-13 | 2.69e-01 | 0.1276 |
375061 | FAM89A | P27T-E | Human | Esophagus | ESCC | 3.72e-04 | -2.59e-03 | 0.1055 |
375061 | FAM89A | P28T-E | Human | Esophagus | ESCC | 7.87e-27 | 6.65e-01 | 0.1149 |
375061 | FAM89A | P30T-E | Human | Esophagus | ESCC | 8.52e-11 | 5.83e-01 | 0.137 |
375061 | FAM89A | P31T-E | Human | Esophagus | ESCC | 9.03e-06 | 7.88e-02 | 0.1251 |
375061 | FAM89A | P32T-E | Human | Esophagus | ESCC | 3.59e-10 | 4.33e-02 | 0.1666 |
375061 | FAM89A | P39T-E | Human | Esophagus | ESCC | 1.43e-03 | 5.76e-02 | 0.0894 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM89A | SNV | Missense_Mutation | c.370N>A | p.Ala124Thr | p.A124T | Q96GI7 | protein_coding | tolerated(0.44) | benign(0.041) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
FAM89A | SNV | Missense_Mutation | novel | c.365A>G | p.Lys122Arg | p.K122R | Q96GI7 | protein_coding | tolerated(0.07) | benign(0.221) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
FAM89A | SNV | Missense_Mutation | novel | c.389N>T | p.Ser130Ile | p.S130I | Q96GI7 | protein_coding | deleterious(0) | possibly_damaging(0.66) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM89A | SNV | Missense_Mutation | novel | c.515C>T | p.Ser172Phe | p.S172F | Q96GI7 | protein_coding | deleterious(0.01) | possibly_damaging(0.568) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM89A | SNV | Missense_Mutation | rs147790876 | c.350N>T | p.Ser117Leu | p.S117L | Q96GI7 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM89A | SNV | Missense_Mutation | novel | c.422N>G | p.Phe141Cys | p.F141C | Q96GI7 | protein_coding | deleterious(0.05) | benign(0.043) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM89A | SNV | Missense_Mutation | novel | c.450N>T | p.Gln150His | p.Q150H | Q96GI7 | protein_coding | tolerated(0.09) | benign(0.085) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM89A | SNV | Missense_Mutation | rs781270213 | c.469N>A | p.Asp157Asn | p.D157N | Q96GI7 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM89A | SNV | Missense_Mutation | c.473N>A | p.Arg158Lys | p.R158K | Q96GI7 | protein_coding | tolerated(0.48) | benign(0.014) | TCGA-55-7727-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FAM89A | SNV | Missense_Mutation | novel | c.455N>T | p.Gln152Leu | p.Q152L | Q96GI7 | protein_coding | deleterious(0.03) | benign(0.167) | TCGA-68-7757-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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