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Gene: FAM83H-AS1 |
Gene summary for FAM83H-AS1 |
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Gene information | Species | Human | Gene symbol | FAM83H-AS1 | Gene ID | 642574 |
Gene name | IQ motif and ankyrin repeat containing 1 | |
Gene Alias | FAM83H-AS1 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
642574 | FAM83H-AS1 | P2T-E | Human | Esophagus | ESCC | 4.77e-05 | 6.12e-02 | 0.1177 |
642574 | FAM83H-AS1 | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.39e-01 | 0.1323 |
642574 | FAM83H-AS1 | P5T-E | Human | Esophagus | ESCC | 2.17e-09 | 9.59e-02 | 0.1327 |
642574 | FAM83H-AS1 | P8T-E | Human | Esophagus | ESCC | 1.21e-03 | 6.55e-02 | 0.0889 |
642574 | FAM83H-AS1 | P9T-E | Human | Esophagus | ESCC | 1.65e-09 | 2.04e-01 | 0.1131 |
642574 | FAM83H-AS1 | P10T-E | Human | Esophagus | ESCC | 3.18e-06 | 5.25e-02 | 0.116 |
642574 | FAM83H-AS1 | P12T-E | Human | Esophagus | ESCC | 9.94e-18 | 3.66e-01 | 0.1122 |
642574 | FAM83H-AS1 | P15T-E | Human | Esophagus | ESCC | 4.01e-11 | 2.40e-01 | 0.1149 |
642574 | FAM83H-AS1 | P16T-E | Human | Esophagus | ESCC | 2.82e-15 | 2.52e-01 | 0.1153 |
642574 | FAM83H-AS1 | P20T-E | Human | Esophagus | ESCC | 3.20e-07 | 1.91e-01 | 0.1124 |
642574 | FAM83H-AS1 | P21T-E | Human | Esophagus | ESCC | 2.33e-11 | 2.59e-01 | 0.1617 |
642574 | FAM83H-AS1 | P23T-E | Human | Esophagus | ESCC | 1.99e-08 | 2.04e-01 | 0.108 |
642574 | FAM83H-AS1 | P24T-E | Human | Esophagus | ESCC | 8.01e-04 | 8.14e-02 | 0.1287 |
642574 | FAM83H-AS1 | P26T-E | Human | Esophagus | ESCC | 3.93e-09 | 1.87e-01 | 0.1276 |
642574 | FAM83H-AS1 | P27T-E | Human | Esophagus | ESCC | 2.93e-12 | 1.53e-01 | 0.1055 |
642574 | FAM83H-AS1 | P28T-E | Human | Esophagus | ESCC | 7.58e-18 | 3.63e-01 | 0.1149 |
642574 | FAM83H-AS1 | P30T-E | Human | Esophagus | ESCC | 3.85e-06 | 1.98e-01 | 0.137 |
642574 | FAM83H-AS1 | P31T-E | Human | Esophagus | ESCC | 9.78e-07 | 1.49e-01 | 0.1251 |
642574 | FAM83H-AS1 | P37T-E | Human | Esophagus | ESCC | 8.12e-03 | 8.52e-02 | 0.1371 |
642574 | FAM83H-AS1 | P39T-E | Human | Esophagus | ESCC | 1.45e-07 | 1.29e-01 | 0.0894 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.824N>A | p.Arg275His | p.R275H | protein_coding | tolerated(0.24) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM83H-AS1 | SNV | Missense_Mutation | rs149608943 | c.149C>T | p.Ser50Leu | p.S50L | protein_coding | tolerated(0.38) | benign(0) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.1387N>G | p.Pro463Ala | p.P463A | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.1477N>A | p.Val493Met | p.V493M | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
FAM83H-AS1 | SNV | Missense_Mutation | rs183174959 | c.1277N>A | p.Arg426His | p.R426H | protein_coding | tolerated(0.19) | benign(0.08) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.884N>A | p.Arg295His | p.R295H | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.1280C>T | p.Ala427Val | p.A427V | protein_coding | tolerated(0.25) | possibly_damaging(0.569) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.1494N>T | p.Glu498Asp | p.E498D | protein_coding | tolerated(0.64) | benign(0.068) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.1337G>A | p.Arg446His | p.R446H | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM83H-AS1 | SNV | Missense_Mutation | novel | c.1657N>A | p.Val553Met | p.V553M | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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