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Gene: FAM71F2 |
Gene summary for FAM71F2 |
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Gene information | Species | Human | Gene symbol | FAM71F2 | Gene ID | 346653 |
Gene name | family with sequence similarity 71 member F2 | |
Gene Alias | FAM137B | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6NXP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
346653 | FAM71F2 | HCC1_Meng | Human | Liver | HCC | 1.61e-08 | 9.11e-03 | 0.0246 |
346653 | FAM71F2 | HCC1 | Human | Liver | HCC | 3.48e-17 | 2.01e+00 | 0.5336 |
346653 | FAM71F2 | HCC2 | Human | Liver | HCC | 4.26e-30 | 2.81e+00 | 0.5341 |
346653 | FAM71F2 | HCC5 | Human | Liver | HCC | 3.20e-20 | 2.02e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM71F2 | SNV | Missense_Mutation | c.310N>A | p.Gly104Ser | p.G104S | Q6NXP2 | protein_coding | deleterious(0.04) | benign(0.021) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM71F2 | deletion | Frame_Shift_Del | novel | c.891delN | p.His297GlnfsTer2 | p.H297Qfs*2 | Q6NXP2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
FAM71F2 | SNV | Missense_Mutation | c.172G>A | p.Asp58Asn | p.D58N | Q6NXP2 | protein_coding | tolerated_low_confidence(0.52) | benign(0.001) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
FAM71F2 | SNV | Missense_Mutation | c.217G>T | p.Gly73Trp | p.G73W | Q6NXP2 | protein_coding | tolerated(0.17) | benign(0.011) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM71F2 | SNV | Missense_Mutation | c.466N>A | p.His156Asn | p.H156N | Q6NXP2 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
FAM71F2 | SNV | Missense_Mutation | c.177C>A | p.Phe59Leu | p.F59L | Q6NXP2 | protein_coding | tolerated_low_confidence(1) | benign(0.433) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM71F2 | SNV | Missense_Mutation | rs200938500 | c.442G>A | p.Glu148Lys | p.E148K | Q6NXP2 | protein_coding | tolerated(0.16) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM71F2 | SNV | Missense_Mutation | novel | c.100N>G | p.Pro34Ala | p.P34A | Q6NXP2 | protein_coding | tolerated(0.14) | probably_damaging(0.994) | TCGA-AJ-A3IA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM71F2 | SNV | Missense_Mutation | c.19N>A | p.Leu7Ile | p.L7I | Q6NXP2 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM71F2 | SNV | Missense_Mutation | c.626N>A | p.Ser209Asn | p.S209N | Q6NXP2 | protein_coding | tolerated(0.09) | benign(0.425) | TCGA-D1-A16F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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