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Gene: FAM71E1 |
Gene summary for FAM71E1 |
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Gene information | Species | Human | Gene symbol | FAM71E1 | Gene ID | 112703 |
Gene name | family with sequence similarity 71 member E1 | |
Gene Alias | FAM71E1 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6IPT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112703 | FAM71E1 | LZE7T | Human | Esophagus | ESCC | 2.26e-04 | 3.09e-01 | 0.0667 |
112703 | FAM71E1 | LZE24T | Human | Esophagus | ESCC | 2.20e-05 | 1.55e-01 | 0.0596 |
112703 | FAM71E1 | P2T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.54e-01 | 0.1177 |
112703 | FAM71E1 | P4T-E | Human | Esophagus | ESCC | 1.89e-10 | 1.88e-01 | 0.1323 |
112703 | FAM71E1 | P8T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.94e-01 | 0.0889 |
112703 | FAM71E1 | P10T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.14e-01 | 0.116 |
112703 | FAM71E1 | P12T-E | Human | Esophagus | ESCC | 3.97e-04 | 9.27e-02 | 0.1122 |
112703 | FAM71E1 | P15T-E | Human | Esophagus | ESCC | 3.53e-04 | 8.43e-02 | 0.1149 |
112703 | FAM71E1 | P16T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.83e-01 | 0.1153 |
112703 | FAM71E1 | P22T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.29e-01 | 0.1236 |
112703 | FAM71E1 | P26T-E | Human | Esophagus | ESCC | 5.87e-84 | 1.25e+00 | 0.1276 |
112703 | FAM71E1 | P27T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.31e-01 | 0.1055 |
112703 | FAM71E1 | P37T-E | Human | Esophagus | ESCC | 8.70e-79 | 2.04e+00 | 0.1371 |
112703 | FAM71E1 | P39T-E | Human | Esophagus | ESCC | 1.88e-04 | 8.88e-02 | 0.0894 |
112703 | FAM71E1 | P48T-E | Human | Esophagus | ESCC | 1.66e-02 | 7.60e-02 | 0.0959 |
112703 | FAM71E1 | P52T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.69e-01 | 0.1555 |
112703 | FAM71E1 | P56T-E | Human | Esophagus | ESCC | 4.82e-07 | 7.91e-01 | 0.1613 |
112703 | FAM71E1 | P61T-E | Human | Esophagus | ESCC | 3.20e-05 | 9.50e-02 | 0.099 |
112703 | FAM71E1 | P62T-E | Human | Esophagus | ESCC | 1.76e-06 | 1.11e-01 | 0.1302 |
112703 | FAM71E1 | P74T-E | Human | Esophagus | ESCC | 3.04e-02 | 1.21e-01 | 0.1479 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM71E1 | SNV | Missense_Mutation | c.449G>T | p.Gly150Val | p.G150V | Q6IPT2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FAM71E1 | SNV | Missense_Mutation | c.355G>A | p.Val119Ile | p.V119I | Q6IPT2 | protein_coding | tolerated(0.58) | possibly_damaging(0.539) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM71E1 | SNV | Missense_Mutation | novel | c.188C>T | p.Ala63Val | p.A63V | Q6IPT2 | protein_coding | tolerated_low_confidence(0.08) | benign(0.029) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM71E1 | SNV | Missense_Mutation | novel | c.641G>A | p.Arg214Gln | p.R214Q | Q6IPT2 | protein_coding | tolerated(0.3) | benign(0.053) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD |
FAM71E1 | SNV | Missense_Mutation | rs760610760 | c.685C>T | p.Arg229Trp | p.R229W | Q6IPT2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM71E1 | SNV | Missense_Mutation | c.284N>A | p.Arg95Gln | p.R95Q | Q6IPT2 | protein_coding | tolerated(0.17) | benign(0.203) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM71E1 | SNV | Missense_Mutation | rs745613786 | c.202N>T | p.Arg68Cys | p.R68C | Q6IPT2 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM71E1 | SNV | Missense_Mutation | novel | c.731T>G | p.Phe244Cys | p.F244C | Q6IPT2 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM71E1 | SNV | Missense_Mutation | novel | c.307N>A | p.Gly103Ser | p.G103S | Q6IPT2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM71E1 | SNV | Missense_Mutation | c.355N>A | p.Val119Ile | p.V119I | Q6IPT2 | protein_coding | tolerated(0.58) | possibly_damaging(0.539) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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