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Gene: FAM71D |
Gene summary for FAM71D |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM71D | Gene ID | 161142 |
| Gene name | family with sequence similarity 71 member D | |
| Gene Alias | C14orf54 | |
| Cytomap | 14q23.3 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8N9W8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 161142 | FAM71D | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.35e-08 | 2.05e-01 | -0.1808 |
| 161142 | FAM71D | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-03 | 1.40e-01 | -0.0811 |
| 161142 | FAM71D | HTA11_78_2000001011 | Human | Colorectum | AD | 6.77e-08 | 2.17e-01 | -0.1088 |
| 161142 | FAM71D | HTA11_347_2000001011 | Human | Colorectum | AD | 3.31e-13 | 2.47e-01 | -0.1954 |
| 161142 | FAM71D | HTA11_411_2000001011 | Human | Colorectum | SER | 4.21e-04 | 3.57e-01 | -0.2602 |
| 161142 | FAM71D | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-03 | 1.58e-01 | -0.1207 |
| 161142 | FAM71D | HTA11_696_2000001011 | Human | Colorectum | AD | 9.55e-09 | 1.75e-01 | -0.1464 |
| 161142 | FAM71D | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | 1.66e-01 | -0.1001 |
| 161142 | FAM71D | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.70e-11 | 3.66e-01 | -0.059 |
| 161142 | FAM71D | HTA11_546_2000001011 | Human | Colorectum | AD | 4.47e-03 | 1.57e-01 | -0.0842 |
| 161142 | FAM71D | HTA11_866_3004761011 | Human | Colorectum | AD | 3.35e-04 | 1.49e-01 | 0.096 |
| 161142 | FAM71D | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.05e-06 | 1.59e-01 | 0.0674 |
| 161142 | FAM71D | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.29e-03 | 2.63e-01 | 0.0112 |
| 161142 | FAM71D | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.24e-08 | 2.89e-01 | 0.0588 |
| 161142 | FAM71D | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.92e-04 | 9.83e-02 | 0.294 |
| 161142 | FAM71D | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.44e-12 | 2.61e-01 | 0.3859 |
| 161142 | FAM71D | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.74e-02 | 2.02e-01 | 0.2585 |
| 161142 | FAM71D | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.25e-05 | 1.23e-01 | 0.3005 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM71D | SNV | Missense_Mutation | novel | c.701N>G | p.Phe234Cys | p.F234C | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.921) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
| FAM71D | SNV | Missense_Mutation | novel | c.467N>G | p.Ser156Cys | p.S156C | Q8N9W8 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| FAM71D | insertion | In_Frame_Ins | novel | c.648_649insACT | p.Thr216dup | p.T216dup | Q8N9W8 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| FAM71D | insertion | Frame_Shift_Ins | novel | c.100_101insCTTTAGGACCTTCTTCTAAGCCTCTGACAAGTTTCAT | p.Asp34AlafsTer38 | p.D34Afs*38 | Q8N9W8 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
| FAM71D | SNV | Missense_Mutation | c.1206N>G | p.Ile402Met | p.I402M | Q8N9W8 | protein_coding | tolerated_low_confidence(0.07) | benign(0.233) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| FAM71D | SNV | Missense_Mutation | c.874N>C | p.Glu292Gln | p.E292Q | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| FAM71D | SNV | Missense_Mutation | novel | c.674N>A | p.Pro225His | p.P225H | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | benign(0.017) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| FAM71D | SNV | Missense_Mutation | c.82N>T | p.Asp28Tyr | p.D28Y | Q8N9W8 | protein_coding | deleterious(0.04) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| FAM71D | SNV | Missense_Mutation | novel | c.1211C>A | p.Ser404Tyr | p.S404Y | Q8N9W8 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.605) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| FAM71D | SNV | Missense_Mutation | rs780986907 | c.773N>T | p.Pro258Leu | p.P258L | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.9) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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