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Gene: FAM63B |
Gene summary for FAM63B |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM63B | Gene ID | 54629 |
Gene name | MINDY lysine 48 deubiquitinase 2 | |
Gene Alias | FAM63B | |
Cytomap | 15q21.3-q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NBR6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54629 | FAM63B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.38e-32 | 5.56e-01 | 0.294 |
54629 | FAM63B | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.49e-22 | 1.35e+00 | 0.3487 |
54629 | FAM63B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.32e-14 | 3.70e-01 | 0.281 |
54629 | FAM63B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.32e-10 | 2.31e-01 | 0.3859 |
54629 | FAM63B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.26e-07 | 2.68e-01 | 0.2585 |
54629 | FAM63B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.40e-09 | 2.25e-01 | 0.3005 |
54629 | FAM63B | P1T-E | Human | Esophagus | ESCC | 2.80e-16 | 7.45e-01 | 0.0875 |
54629 | FAM63B | P2T-E | Human | Esophagus | ESCC | 1.31e-25 | 2.47e-01 | 0.1177 |
54629 | FAM63B | P4T-E | Human | Esophagus | ESCC | 5.42e-23 | 5.42e-01 | 0.1323 |
54629 | FAM63B | P5T-E | Human | Esophagus | ESCC | 4.90e-12 | 2.15e-01 | 0.1327 |
54629 | FAM63B | P8T-E | Human | Esophagus | ESCC | 1.25e-21 | 4.54e-01 | 0.0889 |
54629 | FAM63B | P9T-E | Human | Esophagus | ESCC | 2.24e-16 | 5.26e-01 | 0.1131 |
54629 | FAM63B | P10T-E | Human | Esophagus | ESCC | 2.16e-35 | 7.19e-01 | 0.116 |
54629 | FAM63B | P11T-E | Human | Esophagus | ESCC | 2.06e-15 | 6.08e-01 | 0.1426 |
54629 | FAM63B | P12T-E | Human | Esophagus | ESCC | 1.75e-26 | 5.78e-01 | 0.1122 |
54629 | FAM63B | P15T-E | Human | Esophagus | ESCC | 7.69e-26 | 5.34e-01 | 0.1149 |
54629 | FAM63B | P16T-E | Human | Esophagus | ESCC | 1.45e-19 | 4.17e-01 | 0.1153 |
54629 | FAM63B | P17T-E | Human | Esophagus | ESCC | 8.24e-04 | 2.70e-01 | 0.1278 |
54629 | FAM63B | P19T-E | Human | Esophagus | ESCC | 5.81e-05 | 6.57e-01 | 0.1662 |
54629 | FAM63B | P20T-E | Human | Esophagus | ESCC | 8.72e-24 | 3.53e-01 | 0.1124 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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