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Gene: FAM220A |
Gene summary for FAM220A |
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Gene information | Species | Human | Gene symbol | FAM220A | Gene ID | 84792 |
Gene name | family with sequence similarity 220 member A | |
Gene Alias | ACPIN1 | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q7Z4H9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84792 | FAM220A | LZE24T | Human | Esophagus | ESCC | 2.89e-10 | 1.12e-01 | 0.0596 |
84792 | FAM220A | P1T-E | Human | Esophagus | ESCC | 4.05e-05 | 2.90e-01 | 0.0875 |
84792 | FAM220A | P2T-E | Human | Esophagus | ESCC | 2.89e-24 | 4.11e-01 | 0.1177 |
84792 | FAM220A | P4T-E | Human | Esophagus | ESCC | 3.04e-18 | 5.06e-01 | 0.1323 |
84792 | FAM220A | P5T-E | Human | Esophagus | ESCC | 7.76e-09 | 2.17e-01 | 0.1327 |
84792 | FAM220A | P8T-E | Human | Esophagus | ESCC | 3.80e-16 | 2.30e-01 | 0.0889 |
84792 | FAM220A | P9T-E | Human | Esophagus | ESCC | 1.23e-04 | 2.11e-01 | 0.1131 |
84792 | FAM220A | P10T-E | Human | Esophagus | ESCC | 1.68e-21 | 4.26e-01 | 0.116 |
84792 | FAM220A | P11T-E | Human | Esophagus | ESCC | 1.75e-11 | 5.39e-01 | 0.1426 |
84792 | FAM220A | P12T-E | Human | Esophagus | ESCC | 2.47e-32 | 5.98e-01 | 0.1122 |
84792 | FAM220A | P15T-E | Human | Esophagus | ESCC | 4.76e-20 | 5.60e-01 | 0.1149 |
84792 | FAM220A | P16T-E | Human | Esophagus | ESCC | 2.33e-25 | 4.26e-01 | 0.1153 |
84792 | FAM220A | P17T-E | Human | Esophagus | ESCC | 4.21e-07 | 2.31e-01 | 0.1278 |
84792 | FAM220A | P19T-E | Human | Esophagus | ESCC | 1.06e-06 | 5.49e-01 | 0.1662 |
84792 | FAM220A | P20T-E | Human | Esophagus | ESCC | 2.90e-19 | 4.75e-01 | 0.1124 |
84792 | FAM220A | P21T-E | Human | Esophagus | ESCC | 1.50e-23 | 3.92e-01 | 0.1617 |
84792 | FAM220A | P22T-E | Human | Esophagus | ESCC | 3.53e-14 | 2.98e-01 | 0.1236 |
84792 | FAM220A | P23T-E | Human | Esophagus | ESCC | 4.09e-22 | 5.54e-01 | 0.108 |
84792 | FAM220A | P24T-E | Human | Esophagus | ESCC | 1.90e-10 | 2.41e-01 | 0.1287 |
84792 | FAM220A | P26T-E | Human | Esophagus | ESCC | 1.50e-32 | 6.02e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM220A | SNV | Missense_Mutation | novel | c.254N>T | p.Tyr85Phe | p.Y85F | Q7Z4H9 | protein_coding | tolerated(0.27) | benign(0.387) | TCGA-BH-A5IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
FAM220A | SNV | Missense_Mutation | c.681N>A | p.Phe227Leu | p.F227L | Q7Z4H9 | protein_coding | tolerated(0.1) | benign(0.015) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM220A | SNV | Missense_Mutation | c.239N>A | p.Gly80Asp | p.G80D | Q7Z4H9 | protein_coding | tolerated(0.48) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM220A | SNV | Missense_Mutation | rs551319790 | c.629G>A | p.Arg210His | p.R210H | Q7Z4H9 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FAM220A | SNV | Missense_Mutation | c.684G>T | p.Lys228Asn | p.K228N | Q7Z4H9 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
FAM220A | SNV | Missense_Mutation | c.172N>G | p.Ser58Gly | p.S58G | Q7Z4H9 | protein_coding | tolerated(0.15) | benign(0.037) | TCGA-D5-5538-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium | PD | |
FAM220A | SNV | Missense_Mutation | c.26N>A | p.Gly9Asp | p.G9D | Q7Z4H9 | protein_coding | tolerated(0.09) | benign(0.067) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM220A | SNV | Missense_Mutation | c.556G>A | p.Ala186Thr | p.A186T | Q7Z4H9 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM220A | SNV | Missense_Mutation | rs551319790 | c.629N>A | p.Arg210His | p.R210H | Q7Z4H9 | protein_coding | tolerated(0.57) | benign(0) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM220A | SNV | Missense_Mutation | novel | c.247C>T | p.Leu83Phe | p.L83F | Q7Z4H9 | protein_coding | tolerated(0.22) | benign(0.027) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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