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Gene: FAM21C |
Gene summary for FAM21C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM21C | Gene ID | 253725 |
| Gene name | WASH complex subunit 2C | |
| Gene Alias | FAM21A | |
| Cytomap | 10q11.22 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9Y4E1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 253725 | FAM21C | P1T-E | Human | Esophagus | ESCC | 9.58e-05 | 3.12e-01 | 0.0875 |
| 253725 | FAM21C | P2T-E | Human | Esophagus | ESCC | 1.72e-22 | 3.88e-01 | 0.1177 |
| 253725 | FAM21C | P4T-E | Human | Esophagus | ESCC | 1.35e-15 | 3.68e-01 | 0.1323 |
| 253725 | FAM21C | P5T-E | Human | Esophagus | ESCC | 5.04e-08 | 1.12e-01 | 0.1327 |
| 253725 | FAM21C | P8T-E | Human | Esophagus | ESCC | 9.20e-15 | 3.37e-01 | 0.0889 |
| 253725 | FAM21C | P9T-E | Human | Esophagus | ESCC | 2.43e-08 | 1.71e-01 | 0.1131 |
| 253725 | FAM21C | P10T-E | Human | Esophagus | ESCC | 2.24e-05 | 1.63e-01 | 0.116 |
| 253725 | FAM21C | P11T-E | Human | Esophagus | ESCC | 6.66e-10 | 5.15e-01 | 0.1426 |
| 253725 | FAM21C | P12T-E | Human | Esophagus | ESCC | 1.70e-19 | 3.85e-01 | 0.1122 |
| 253725 | FAM21C | P15T-E | Human | Esophagus | ESCC | 3.32e-08 | 2.96e-01 | 0.1149 |
| 253725 | FAM21C | P16T-E | Human | Esophagus | ESCC | 4.40e-12 | 1.93e-01 | 0.1153 |
| 253725 | FAM21C | P17T-E | Human | Esophagus | ESCC | 2.48e-04 | 3.17e-01 | 0.1278 |
| 253725 | FAM21C | P19T-E | Human | Esophagus | ESCC | 1.49e-07 | 3.06e-01 | 0.1662 |
| 253725 | FAM21C | P20T-E | Human | Esophagus | ESCC | 4.18e-15 | 2.15e-01 | 0.1124 |
| 253725 | FAM21C | P21T-E | Human | Esophagus | ESCC | 1.41e-28 | 5.56e-01 | 0.1617 |
| 253725 | FAM21C | P22T-E | Human | Esophagus | ESCC | 1.47e-15 | 2.03e-01 | 0.1236 |
| 253725 | FAM21C | P23T-E | Human | Esophagus | ESCC | 4.63e-22 | 5.98e-01 | 0.108 |
| 253725 | FAM21C | P24T-E | Human | Esophagus | ESCC | 1.80e-17 | 4.17e-01 | 0.1287 |
| 253725 | FAM21C | P26T-E | Human | Esophagus | ESCC | 1.22e-15 | 2.82e-01 | 0.1276 |
| 253725 | FAM21C | P27T-E | Human | Esophagus | ESCC | 1.09e-22 | 4.96e-01 | 0.1055 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
| hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
| hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
| hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
| hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
| hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
| hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
| hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
| hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
| hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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