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Gene: FAM219A |
Gene summary for FAM219A |
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Gene information | Species | Human | Gene symbol | FAM219A | Gene ID | 203259 |
Gene name | family with sequence similarity 219 member A | |
Gene Alias | C9orf25 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8IW50 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203259 | FAM219A | C04 | Human | Oral cavity | OSCC | 1.50e-04 | 3.05e-01 | 0.2633 |
203259 | FAM219A | C21 | Human | Oral cavity | OSCC | 1.03e-12 | 3.91e-01 | 0.2678 |
203259 | FAM219A | C30 | Human | Oral cavity | OSCC | 1.88e-14 | 6.42e-01 | 0.3055 |
203259 | FAM219A | C38 | Human | Oral cavity | OSCC | 5.43e-09 | 7.06e-01 | 0.172 |
203259 | FAM219A | C46 | Human | Oral cavity | OSCC | 1.27e-03 | 1.10e-01 | 0.1673 |
203259 | FAM219A | C51 | Human | Oral cavity | OSCC | 2.88e-04 | 3.01e-01 | 0.2674 |
203259 | FAM219A | EOLP-1 | Human | Oral cavity | EOLP | 1.86e-04 | 1.04e-01 | -0.0202 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM219A | SNV | Missense_Mutation | c.422N>C | p.Ile141Thr | p.I141T | Q8IW50 | protein_coding | tolerated(0.13) | probably_damaging(0.99) | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM219A | SNV | Missense_Mutation | novel | c.436G>C | p.Asp146His | p.D146H | Q8IW50 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM219A | SNV | Missense_Mutation | c.271N>A | p.Val91Ile | p.V91I | Q8IW50 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
FAM219A | insertion | Frame_Shift_Ins | rs760074479 | c.492_493insC | p.Lys165GlnfsTer39 | p.K165Qfs*39 | Q8IW50 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAM219A | SNV | Missense_Mutation | rs759172112 | c.382G>A | p.Gly128Ser | p.G128S | Q8IW50 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM219A | SNV | Missense_Mutation | novel | c.320N>T | p.Pro107Leu | p.P107L | Q8IW50 | protein_coding | deleterious(0.01) | benign(0.085) | TCGA-AA-3980-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM219A | SNV | Missense_Mutation | rs780786312 | c.70N>A | p.Ala24Thr | p.A24T | Q8IW50 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM219A | deletion | Frame_Shift_Del | c.492delC | p.Lys165SerfsTer3 | p.K165Sfs*3 | Q8IW50 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
FAM219A | SNV | Missense_Mutation | novel | c.218N>A | p.Pro73His | p.P73H | Q8IW50 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
FAM219A | SNV | Missense_Mutation | novel | c.198N>T | p.Lys66Asn | p.K66N | Q8IW50 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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