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Gene: FAM213B |
Gene summary for FAM213B |
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Gene information | Species | Human | Gene symbol | FAM213B | Gene ID | 127281 |
Gene name | peroxiredoxin like 2B | |
Gene Alias | C1orf93 | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0001516 | UniProtAcc | A0A0A0MT35 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
127281 | FAM213B | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.52e-06 | 7.53e-01 | 0.3487 |
127281 | FAM213B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.47e-06 | 2.44e-01 | 0.281 |
127281 | FAM213B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.05e-29 | 6.72e-01 | 0.3859 |
127281 | FAM213B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.96e-03 | 2.14e-01 | 0.2585 |
127281 | FAM213B | P2T-E | Human | Esophagus | ESCC | 5.22e-07 | 1.81e-01 | 0.1177 |
127281 | FAM213B | P4T-E | Human | Esophagus | ESCC | 2.35e-18 | 3.91e-01 | 0.1323 |
127281 | FAM213B | P5T-E | Human | Esophagus | ESCC | 5.36e-06 | 1.26e-01 | 0.1327 |
127281 | FAM213B | P8T-E | Human | Esophagus | ESCC | 2.34e-19 | 4.33e-01 | 0.0889 |
127281 | FAM213B | P10T-E | Human | Esophagus | ESCC | 2.19e-07 | 1.34e-01 | 0.116 |
127281 | FAM213B | P11T-E | Human | Esophagus | ESCC | 3.45e-08 | 3.20e-01 | 0.1426 |
127281 | FAM213B | P12T-E | Human | Esophagus | ESCC | 2.42e-06 | 1.48e-01 | 0.1122 |
127281 | FAM213B | P15T-E | Human | Esophagus | ESCC | 2.01e-12 | 1.40e-01 | 0.1149 |
127281 | FAM213B | P16T-E | Human | Esophagus | ESCC | 2.30e-05 | 2.04e-01 | 0.1153 |
127281 | FAM213B | P17T-E | Human | Esophagus | ESCC | 3.56e-03 | 2.09e-01 | 0.1278 |
127281 | FAM213B | P19T-E | Human | Esophagus | ESCC | 2.26e-02 | 1.87e-01 | 0.1662 |
127281 | FAM213B | P20T-E | Human | Esophagus | ESCC | 1.07e-12 | 1.85e-01 | 0.1124 |
127281 | FAM213B | P21T-E | Human | Esophagus | ESCC | 2.78e-20 | 4.26e-01 | 0.1617 |
127281 | FAM213B | P23T-E | Human | Esophagus | ESCC | 1.02e-15 | 1.99e-01 | 0.108 |
127281 | FAM213B | P26T-E | Human | Esophagus | ESCC | 1.16e-03 | 9.76e-02 | 0.1276 |
127281 | FAM213B | P27T-E | Human | Esophagus | ESCC | 9.95e-10 | 2.07e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM213B | SNV | Missense_Mutation | rs200164303 | c.631G>A | p.Val211Ile | p.V211I | protein_coding | tolerated(0.55) | benign(0.038) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM213B | SNV | Missense_Mutation | novel | c.85N>A | p.Ala29Thr | p.A29T | protein_coding | deleterious_low_confidence(0.01) | benign(0.376) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM213B | SNV | Missense_Mutation | c.643C>A | p.Pro215Thr | p.P215T | protein_coding | deleterious(0.03) | probably_damaging(0.967) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
FAM213B | SNV | Missense_Mutation | novel | c.671T>C | p.Ile224Thr | p.I224T | protein_coding | deleterious(0) | possibly_damaging(0.713) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM213B | SNV | Missense_Mutation | rs748716490 | c.512G>A | p.Arg171His | p.R171H | protein_coding | deleterious(0.03) | benign(0.045) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM213B | SNV | Missense_Mutation | c.643N>G | p.Pro215Ala | p.P215A | protein_coding | tolerated(0.24) | benign(0.365) | TCGA-DD-A1EL-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
FAM213B | SNV | Missense_Mutation | c.603N>C | p.Lys201Asn | p.K201N | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | ||
FAM213B | SNV | Missense_Mutation | rs757946334 | c.580G>A | p.Gly194Arg | p.G194R | protein_coding | tolerated(0.07) | possibly_damaging(0.905) | TCGA-XC-AA0X-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM213B | SNV | Missense_Mutation | c.601N>C | p.Lys201Gln | p.K201Q | protein_coding | tolerated(0.06) | possibly_damaging(0.885) | TCGA-BR-8676-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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