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Gene: FAM213A |
Gene summary for FAM213A |
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Gene information | Species | Human | Gene symbol | FAM213A | Gene ID | 84293 |
Gene name | peroxiredoxin like 2A | |
Gene Alias | Adrx | |
Cytomap | 10q23.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9BRX8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84293 | FAM213A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.72e-06 | -2.05e-01 | 0.0155 |
84293 | FAM213A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.06e-02 | -2.05e-01 | -0.1808 |
84293 | FAM213A | HTA11_78_2000001011 | Human | Colorectum | AD | 1.26e-03 | -2.05e-01 | -0.1088 |
84293 | FAM213A | HTA11_347_2000001011 | Human | Colorectum | AD | 6.10e-07 | -2.05e-01 | -0.1954 |
84293 | FAM213A | HTA11_696_2000001011 | Human | Colorectum | AD | 9.56e-07 | -2.05e-01 | -0.1464 |
84293 | FAM213A | HTA11_866_2000001011 | Human | Colorectum | AD | 2.05e-06 | -2.05e-01 | -0.1001 |
84293 | FAM213A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.27e-04 | -2.05e-01 | -0.059 |
84293 | FAM213A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.93e-05 | -2.05e-01 | 0.096 |
84293 | FAM213A | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.43e-02 | -2.05e-01 | 0.0338 |
84293 | FAM213A | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.05e-06 | -2.05e-01 | 0.0674 |
84293 | FAM213A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.50e-15 | 5.45e-01 | 0.294 |
84293 | FAM213A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.85e-36 | 1.10e+00 | 0.3859 |
84293 | FAM213A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.82e-05 | 6.02e-01 | 0.2585 |
84293 | FAM213A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.87e-05 | 3.40e-01 | 0.3005 |
84293 | FAM213A | AEH-subject1 | Human | Endometrium | AEH | 2.12e-50 | -7.05e-01 | -0.3059 |
84293 | FAM213A | AEH-subject2 | Human | Endometrium | AEH | 1.16e-48 | -7.05e-01 | -0.2525 |
84293 | FAM213A | AEH-subject3 | Human | Endometrium | AEH | 6.20e-50 | -7.05e-01 | -0.2576 |
84293 | FAM213A | AEH-subject4 | Human | Endometrium | AEH | 2.16e-38 | -7.05e-01 | -0.2657 |
84293 | FAM213A | AEH-subject5 | Human | Endometrium | AEH | 6.20e-50 | -7.05e-01 | -0.2953 |
84293 | FAM213A | EEC-subject1 | Human | Endometrium | EEC | 1.03e-53 | -7.05e-01 | -0.2682 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM213A | SNV | Missense_Mutation | novel | c.643N>T | p.Ala215Ser | p.A215S | Q9BRX8 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-A6-3807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
FAM213A | SNV | Missense_Mutation | rs770934321 | c.131N>T | p.Ala44Val | p.A44V | Q9BRX8 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM213A | SNV | Missense_Mutation | rs774815541 | c.608T>G | p.Phe203Cys | p.F203C | Q9BRX8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM213A | SNV | Missense_Mutation | c.5C>G | p.Ser2Cys | p.S2C | Q9BRX8 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.594) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
FAM213A | SNV | Missense_Mutation | novel | c.479N>G | p.Tyr160Cys | p.Y160C | Q9BRX8 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM213A | SNV | Missense_Mutation | rs138058462 | c.241N>T | p.Arg81Trp | p.R81W | Q9BRX8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
FAM213A | SNV | Missense_Mutation | c.353N>T | p.Arg118Met | p.R118M | Q9BRX8 | protein_coding | deleterious(0) | possibly_damaging(0.643) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM213A | SNV | Missense_Mutation | c.420N>A | p.Phe140Leu | p.F140L | Q9BRX8 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM213A | SNV | Missense_Mutation | rs138058462 | c.241N>T | p.Arg81Trp | p.R81W | Q9BRX8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM213A | SNV | Missense_Mutation | novel | c.592N>T | p.His198Tyr | p.H198Y | Q9BRX8 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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