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Gene: FAM208B |
Gene summary for FAM208B |
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Gene information | Species | Human | Gene symbol | FAM208B | Gene ID | 54906 |
Gene name | transcription activation suppressor family member 2 | |
Gene Alias | C10orf18 | |
Cytomap | 10p15.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5VWN6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54906 | FAM208B | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.33e-55 | -1.07e+00 | 0.0155 |
54906 | FAM208B | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-34 | -1.07e+00 | -0.1808 |
54906 | FAM208B | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.33e-10 | -1.07e+00 | 0.0216 |
54906 | FAM208B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.81e-27 | -1.07e+00 | -0.0811 |
54906 | FAM208B | HTA11_78_2000001011 | Human | Colorectum | AD | 6.32e-40 | -1.07e+00 | -0.1088 |
54906 | FAM208B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-58 | -1.07e+00 | -0.1954 |
54906 | FAM208B | HTA11_411_2000001011 | Human | Colorectum | SER | 8.47e-07 | -1.07e+00 | -0.2602 |
54906 | FAM208B | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.52e-09 | -1.07e+00 | -0.2196 |
54906 | FAM208B | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.51e-28 | -1.07e+00 | -0.1207 |
54906 | FAM208B | HTA11_83_2000001011 | Human | Colorectum | SER | 2.64e-23 | -1.07e+00 | -0.1526 |
54906 | FAM208B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.67e-73 | -1.07e+00 | -0.1464 |
54906 | FAM208B | HTA11_866_2000001011 | Human | Colorectum | AD | 4.88e-69 | -1.07e+00 | -0.1001 |
54906 | FAM208B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.41e-45 | -1.07e+00 | -0.059 |
54906 | FAM208B | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.20e-12 | -1.07e+00 | -0.1706 |
54906 | FAM208B | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.69e-14 | -1.07e+00 | -0.2061 |
54906 | FAM208B | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.33e-10 | -1.07e+00 | -0.1462 |
54906 | FAM208B | HTA11_546_2000001011 | Human | Colorectum | AD | 1.31e-20 | -1.07e+00 | -0.0842 |
54906 | FAM208B | HTA11_9341_2000001011 | Human | Colorectum | SER | 8.47e-07 | -1.07e+00 | -0.00410000000000005 |
54906 | FAM208B | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.80e-17 | -1.07e+00 | -0.0179 |
54906 | FAM208B | HTA11_866_3004761011 | Human | Colorectum | AD | 3.63e-49 | -1.07e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM208B | SNV | Missense_Mutation | novel | c.2631C>A | p.Phe877Leu | p.F877L | Q5VWN6 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
FAM208B | SNV | Missense_Mutation | novel | c.6707N>G | p.Glu2236Gly | p.E2236G | Q5VWN6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
FAM208B | SNV | Missense_Mutation | c.5803A>C | p.Lys1935Gln | p.K1935Q | Q5VWN6 | protein_coding | tolerated(0.2) | benign(0.07) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
FAM208B | SNV | Missense_Mutation | novel | c.4538N>G | p.Ser1513Cys | p.S1513C | Q5VWN6 | protein_coding | deleterious(0.01) | possibly_damaging(0.887) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM208B | SNV | Missense_Mutation | c.6940N>C | p.Trp2314Arg | p.W2314R | Q5VWN6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
FAM208B | SNV | Missense_Mutation | c.1771C>G | p.Gln591Glu | p.Q591E | Q5VWN6 | protein_coding | tolerated(0.07) | benign(0.388) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM208B | SNV | Missense_Mutation | novel | c.160N>T | p.Asp54Tyr | p.D54Y | Q5VWN6 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM208B | SNV | Missense_Mutation | c.5390G>A | p.Ser1797Asn | p.S1797N | Q5VWN6 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM208B | SNV | Missense_Mutation | c.6811N>G | p.His2271Asp | p.H2271D | Q5VWN6 | protein_coding | tolerated(0.73) | benign(0) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
FAM208B | SNV | Missense_Mutation | c.3182A>G | p.His1061Arg | p.H1061R | Q5VWN6 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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