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Gene: FAM206A |
Gene summary for FAM206A |
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Gene information | Species | Human | Gene symbol | FAM206A | Gene ID | 54942 |
Gene name | actin binding transcription modulator | |
Gene Alias | C9orf6 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NX38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54942 | FAM206A | P1T-E | Human | Esophagus | ESCC | 9.15e-04 | 1.61e-01 | 0.0875 |
54942 | FAM206A | P2T-E | Human | Esophagus | ESCC | 2.59e-29 | 4.05e-01 | 0.1177 |
54942 | FAM206A | P4T-E | Human | Esophagus | ESCC | 1.42e-11 | 2.11e-01 | 0.1323 |
54942 | FAM206A | P5T-E | Human | Esophagus | ESCC | 2.25e-22 | 4.28e-01 | 0.1327 |
54942 | FAM206A | P8T-E | Human | Esophagus | ESCC | 1.33e-11 | 1.64e-01 | 0.0889 |
54942 | FAM206A | P9T-E | Human | Esophagus | ESCC | 1.08e-08 | 8.90e-02 | 0.1131 |
54942 | FAM206A | P10T-E | Human | Esophagus | ESCC | 3.55e-24 | 3.36e-01 | 0.116 |
54942 | FAM206A | P11T-E | Human | Esophagus | ESCC | 1.04e-09 | 2.55e-01 | 0.1426 |
54942 | FAM206A | P12T-E | Human | Esophagus | ESCC | 8.15e-13 | 1.85e-01 | 0.1122 |
54942 | FAM206A | P15T-E | Human | Esophagus | ESCC | 2.96e-13 | 3.25e-01 | 0.1149 |
54942 | FAM206A | P16T-E | Human | Esophagus | ESCC | 3.70e-16 | 2.17e-01 | 0.1153 |
54942 | FAM206A | P17T-E | Human | Esophagus | ESCC | 3.37e-09 | 2.34e-01 | 0.1278 |
54942 | FAM206A | P19T-E | Human | Esophagus | ESCC | 2.27e-04 | 4.92e-01 | 0.1662 |
54942 | FAM206A | P20T-E | Human | Esophagus | ESCC | 7.68e-09 | 2.05e-01 | 0.1124 |
54942 | FAM206A | P21T-E | Human | Esophagus | ESCC | 1.97e-26 | 5.47e-01 | 0.1617 |
54942 | FAM206A | P22T-E | Human | Esophagus | ESCC | 4.47e-09 | 1.14e-01 | 0.1236 |
54942 | FAM206A | P23T-E | Human | Esophagus | ESCC | 1.10e-13 | 3.57e-01 | 0.108 |
54942 | FAM206A | P24T-E | Human | Esophagus | ESCC | 7.52e-17 | 3.75e-01 | 0.1287 |
54942 | FAM206A | P26T-E | Human | Esophagus | ESCC | 1.37e-08 | 1.53e-01 | 0.1276 |
54942 | FAM206A | P27T-E | Human | Esophagus | ESCC | 1.90e-18 | 1.85e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM206A | SNV | Missense_Mutation | c.357G>C | p.Leu119Phe | p.L119F | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
FAM206A | insertion | Frame_Shift_Ins | novel | c.221_222insTA | p.Ser75IlefsTer19 | p.S75Ifs*19 | Q9NX38 | protein_coding | TCGA-AG-A00C-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
FAM206A | SNV | Missense_Mutation | novel | c.353N>A | p.Arg118His | p.R118H | Q9NX38 | protein_coding | deleterious(0.02) | probably_damaging(0.938) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM206A | SNV | Missense_Mutation | novel | c.265N>A | p.Ala89Thr | p.A89T | Q9NX38 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
FAM206A | SNV | Missense_Mutation | c.20C>T | p.Ala7Val | p.A7V | Q9NX38 | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM206A | SNV | Missense_Mutation | novel | c.56A>G | p.Tyr19Cys | p.Y19C | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FAM206A | SNV | Missense_Mutation | novel | c.137N>A | p.Cys46Tyr | p.C46Y | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM206A | SNV | Missense_Mutation | novel | c.217N>G | p.Asn73Asp | p.N73D | Q9NX38 | protein_coding | tolerated(0.29) | benign(0.139) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FAM206A | SNV | Missense_Mutation | novel | c.313N>C | p.Asp105His | p.D105H | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
FAM206A | SNV | Missense_Mutation | novel | c.151N>A | p.Ala51Thr | p.A51T | Q9NX38 | protein_coding | deleterious(0.02) | benign(0.29) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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