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Gene: FAM175B |
Gene summary for FAM175B |
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Gene information | Species | Human | Gene symbol | FAM175B | Gene ID | 23172 |
Gene name | abraxas 2, BRISC complex subunit | |
Gene Alias | ABRO1 | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q15018 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23172 | FAM175B | P1T-E | Human | Esophagus | ESCC | 2.64e-05 | 2.59e-01 | 0.0875 |
23172 | FAM175B | P2T-E | Human | Esophagus | ESCC | 2.89e-20 | 3.82e-01 | 0.1177 |
23172 | FAM175B | P4T-E | Human | Esophagus | ESCC | 1.63e-13 | 3.45e-01 | 0.1323 |
23172 | FAM175B | P5T-E | Human | Esophagus | ESCC | 7.24e-18 | 3.83e-01 | 0.1327 |
23172 | FAM175B | P8T-E | Human | Esophagus | ESCC | 2.57e-12 | 2.17e-01 | 0.0889 |
23172 | FAM175B | P9T-E | Human | Esophagus | ESCC | 9.46e-04 | 1.40e-01 | 0.1131 |
23172 | FAM175B | P10T-E | Human | Esophagus | ESCC | 3.31e-12 | 1.41e-01 | 0.116 |
23172 | FAM175B | P11T-E | Human | Esophagus | ESCC | 3.64e-06 | 1.71e-01 | 0.1426 |
23172 | FAM175B | P12T-E | Human | Esophagus | ESCC | 3.12e-21 | 3.93e-01 | 0.1122 |
23172 | FAM175B | P15T-E | Human | Esophagus | ESCC | 4.23e-15 | 3.25e-01 | 0.1149 |
23172 | FAM175B | P16T-E | Human | Esophagus | ESCC | 2.34e-18 | 3.46e-01 | 0.1153 |
23172 | FAM175B | P17T-E | Human | Esophagus | ESCC | 1.73e-03 | 1.70e-01 | 0.1278 |
23172 | FAM175B | P20T-E | Human | Esophagus | ESCC | 2.18e-10 | 2.26e-01 | 0.1124 |
23172 | FAM175B | P21T-E | Human | Esophagus | ESCC | 7.17e-06 | 1.83e-01 | 0.1617 |
23172 | FAM175B | P22T-E | Human | Esophagus | ESCC | 9.58e-08 | 1.74e-01 | 0.1236 |
23172 | FAM175B | P23T-E | Human | Esophagus | ESCC | 1.16e-16 | 4.43e-01 | 0.108 |
23172 | FAM175B | P24T-E | Human | Esophagus | ESCC | 3.26e-22 | 5.07e-01 | 0.1287 |
23172 | FAM175B | P26T-E | Human | Esophagus | ESCC | 3.83e-19 | 3.21e-01 | 0.1276 |
23172 | FAM175B | P27T-E | Human | Esophagus | ESCC | 1.12e-16 | 3.03e-01 | 0.1055 |
23172 | FAM175B | P28T-E | Human | Esophagus | ESCC | 3.57e-15 | 2.88e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM175B | SNV | Missense_Mutation | novel | c.691G>A | p.Glu231Lys | p.E231K | Q15018 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM175B | SNV | Missense_Mutation | c.1132G>A | p.Glu378Lys | p.E378K | Q15018 | protein_coding | deleterious_low_confidence(0) | benign(0.048) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD | |
FAM175B | SNV | Missense_Mutation | novel | c.776G>T | p.Arg259Ile | p.R259I | Q15018 | protein_coding | tolerated(0.23) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM175B | SNV | Missense_Mutation | c.998G>A | p.Arg333Gln | p.R333Q | Q15018 | protein_coding | tolerated(0.08) | probably_damaging(0.996) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM175B | SNV | Missense_Mutation | c.580N>G | p.Thr194Ala | p.T194A | Q15018 | protein_coding | tolerated(0.79) | benign(0.013) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM175B | SNV | Missense_Mutation | c.82N>G | p.Leu28Val | p.L28V | Q15018 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM175B | insertion | Frame_Shift_Ins | novel | c.585_586insT | p.Asp198Ter | p.D198* | Q15018 | protein_coding | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
FAM175B | SNV | Missense_Mutation | novel | c.1054N>T | p.Pro352Ser | p.P352S | Q15018 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM175B | SNV | Missense_Mutation | rs761847350 | c.1037N>A | p.Ser346Asn | p.S346N | Q15018 | protein_coding | tolerated(0.24) | benign(0.006) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM175B | SNV | Missense_Mutation | rs766863439 | c.799N>G | p.Ser267Gly | p.S267G | Q15018 | protein_coding | tolerated(0.26) | benign(0.088) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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