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Gene: FAM175A |
Gene summary for FAM175A |
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Gene information | Species | Human | Gene symbol | FAM175A | Gene ID | 84142 |
Gene name | abraxas 1, BRCA1 A complex subunit | |
Gene Alias | ABRA1 | |
Cytomap | 4q21.23 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q6UWZ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84142 | FAM175A | P2T-E | Human | Esophagus | ESCC | 2.20e-13 | 2.14e-01 | 0.1177 |
84142 | FAM175A | P4T-E | Human | Esophagus | ESCC | 2.74e-17 | 3.10e-01 | 0.1323 |
84142 | FAM175A | P8T-E | Human | Esophagus | ESCC | 1.15e-05 | 4.62e-02 | 0.0889 |
84142 | FAM175A | P9T-E | Human | Esophagus | ESCC | 1.15e-06 | 1.81e-01 | 0.1131 |
84142 | FAM175A | P10T-E | Human | Esophagus | ESCC | 7.16e-09 | 7.92e-02 | 0.116 |
84142 | FAM175A | P11T-E | Human | Esophagus | ESCC | 1.42e-07 | 1.99e-01 | 0.1426 |
84142 | FAM175A | P12T-E | Human | Esophagus | ESCC | 2.48e-15 | 2.63e-01 | 0.1122 |
84142 | FAM175A | P15T-E | Human | Esophagus | ESCC | 1.41e-13 | 3.72e-01 | 0.1149 |
84142 | FAM175A | P16T-E | Human | Esophagus | ESCC | 5.02e-13 | 9.10e-02 | 0.1153 |
84142 | FAM175A | P19T-E | Human | Esophagus | ESCC | 4.93e-03 | 2.92e-01 | 0.1662 |
84142 | FAM175A | P20T-E | Human | Esophagus | ESCC | 1.08e-11 | 1.25e-01 | 0.1124 |
84142 | FAM175A | P21T-E | Human | Esophagus | ESCC | 2.12e-09 | 1.82e-01 | 0.1617 |
84142 | FAM175A | P23T-E | Human | Esophagus | ESCC | 1.21e-08 | 1.54e-01 | 0.108 |
84142 | FAM175A | P24T-E | Human | Esophagus | ESCC | 9.31e-03 | 5.97e-02 | 0.1287 |
84142 | FAM175A | P26T-E | Human | Esophagus | ESCC | 7.06e-21 | 3.45e-01 | 0.1276 |
84142 | FAM175A | P27T-E | Human | Esophagus | ESCC | 4.23e-19 | 1.70e-01 | 0.1055 |
84142 | FAM175A | P28T-E | Human | Esophagus | ESCC | 7.88e-25 | 4.88e-01 | 0.1149 |
84142 | FAM175A | P30T-E | Human | Esophagus | ESCC | 7.95e-14 | 2.66e-01 | 0.137 |
84142 | FAM175A | P31T-E | Human | Esophagus | ESCC | 5.41e-12 | 1.52e-01 | 0.1251 |
84142 | FAM175A | P32T-E | Human | Esophagus | ESCC | 7.69e-20 | 3.48e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM175A | SNV | Missense_Mutation | c.1109N>G | p.Ser370Cys | p.S370C | Q6UWZ7 | protein_coding | tolerated_low_confidence(0.18) | benign(0.001) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
FAM175A | SNV | Missense_Mutation | novel | c.100C>T | p.Leu34Phe | p.L34F | Q6UWZ7 | protein_coding | deleterious(0.03) | benign(0.063) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM175A | insertion | Nonsense_Mutation | novel | c.1171_1172insGCTATATACTTTGAAAATTTGCAGAACTCTTCAAATGAT | p.Asp391delinsGlyTyrIleLeuTerLysPheAlaGluLeuPheLysTerTyr | p.D391delinsGYIL*KFAELFK*Y | Q6UWZ7 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
FAM175A | SNV | Missense_Mutation | c.801N>C | p.Glu267Asp | p.E267D | Q6UWZ7 | protein_coding | tolerated(0.25) | possibly_damaging(0.6) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM175A | SNV | Missense_Mutation | novel | c.790N>T | p.Ala264Ser | p.A264S | Q6UWZ7 | protein_coding | tolerated(0.61) | benign(0.003) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FAM175A | SNV | Missense_Mutation | rs748680448 | c.307N>T | p.Arg103Cys | p.R103C | Q6UWZ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6605-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfox | SD |
FAM175A | SNV | Missense_Mutation | novel | c.1198T>G | p.Phe400Val | p.F400V | Q6UWZ7 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
FAM175A | SNV | Missense_Mutation | novel | c.641A>C | p.Lys214Thr | p.K214T | Q6UWZ7 | protein_coding | tolerated(0.14) | probably_damaging(0.943) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM175A | SNV | Missense_Mutation | novel | c.803N>C | p.Lys268Thr | p.K268T | Q6UWZ7 | protein_coding | tolerated(0.21) | benign(0.167) | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM175A | SNV | Missense_Mutation | novel | c.1151N>C | p.Lys384Thr | p.K384T | Q6UWZ7 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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