![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FAM167A |
Gene summary for FAM167A |
![]() |
Gene information | Species | Human | Gene symbol | FAM167A | Gene ID | 83648 |
Gene name | family with sequence similarity 167 member A | |
Gene Alias | C8orf13 | |
Cytomap | 8p23.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96KS9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83648 | FAM167A | male-WTA | Human | Thyroid | PTC | 1.33e-03 | -2.42e-02 | 0.1037 |
83648 | FAM167A | PTC07 | Human | Thyroid | PTC | 1.43e-04 | -1.34e-01 | 0.2044 |
83648 | FAM167A | ATC12 | Human | Thyroid | ATC | 2.23e-08 | -5.07e-02 | 0.34 |
83648 | FAM167A | ATC4 | Human | Thyroid | ATC | 1.49e-07 | -2.84e-02 | 0.34 |
83648 | FAM167A | ATC5 | Human | Thyroid | ATC | 4.82e-02 | -1.60e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM167A | SNV | Missense_Mutation | c.218N>T | p.Glu73Val | p.E73V | Q96KS9 | protein_coding | tolerated(0.18) | benign(0.107) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
FAM167A | SNV | Missense_Mutation | c.155G>T | p.Arg52Met | p.R52M | Q96KS9 | protein_coding | deleterious(0) | possibly_damaging(0.533) | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | CR | ||
FAM167A | SNV | Missense_Mutation | c.556N>T | p.Leu186Phe | p.L186F | Q96KS9 | protein_coding | tolerated(0.05) | probably_damaging(0.974) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
FAM167A | insertion | In_Frame_Ins | novel | c.536_537insGGTCTCGGGCTG | p.Asp179delinsGluValSerGlyCys | p.D179delinsEVSGC | Q96KS9 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD | ||
FAM167A | insertion | Frame_Shift_Ins | novel | c.534_535insAACCTCTTTCCAGATAAGCCCTT | p.Asp179AsnfsTer31 | p.D179Nfs*31 | Q96KS9 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD | ||
FAM167A | SNV | Missense_Mutation | novel | c.5N>T | p.Ser2Phe | p.S2F | Q96KS9 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM167A | SNV | Missense_Mutation | c.437N>T | p.Gly146Val | p.G146V | Q96KS9 | protein_coding | tolerated(0.14) | possibly_damaging(0.679) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM167A | SNV | Missense_Mutation | c.508N>A | p.Glu170Lys | p.E170K | Q96KS9 | protein_coding | tolerated(0.07) | probably_damaging(0.909) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM167A | SNV | Missense_Mutation | rs370162158 | c.194C>T | p.Ala65Val | p.A65V | Q96KS9 | protein_coding | tolerated(0.29) | benign(0.104) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FAM167A | SNV | Missense_Mutation | c.614N>T | p.Asn205Ile | p.N205I | Q96KS9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3898-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |